Results 21 to 30 of about 247,768 (261)

Evaluation of the relation between T-Lymphocytes (CD4 + ve and CD8 + ve) and pemphigus vulgaris pathogenesis and severity

Indian Journal of Dermatopathology and Diagnostic Dermatology, 2019
Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease involving both the skin and mucus membranes. Infiltrating CD4+ and CD8+ T-lymphocytes may have a vital role in its pathogenesis.
Samia Mohamed El-Said Abd El-Naby, Maha Mohamed Amin, Manar Ali Hassan Ali, Mohammad A Gaballah   +3 more
doaj   +1 more source

Analysis of WB band type and the first test results of CD4+ T lymphocytes in HIV-1 antibody positive patients

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To analyze the WB band and the first test results of CD4+ T lymphocytes in 226 patients with HIV-1 antibody positive in order to reveal the WB pattern and to explore disease progression and immune status, providing the basis for classification
Miaolin HUANG, Junhe LIANG, Jianqi ZOU, Minchao FENG, Hongzhu CAI, Xi'an ZHONG   +5 more
doaj   +1 more source

Functional exhaustion of CD4⁺T cells in HIV/HCV coinfected HAART-treated patients

Медицинская иммунология, 2023
Infection with hepatitis C virus (HCV) is common among HIV-positive patients, with up to 50% of them being coinfected in Russia. While highly active antiretroviral therapy (HAART) suppresses HIV replication and restores the immune system of HIV-infected ...
V. V. Vlasova, L. B. Korolevskaya, O. A. Loginova, N. G. Shmagel, E. V. Saidakova   +4 more
doaj   +1 more source

Regulatory T cells in children with recently diagnosed type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2012
Background: Regulatory T cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes (T1D).
Asmaa Mohamed Zahran, Khalid Ibrahem Elsayh, Kotb Abbass Metwalley   +2 more
doaj   +1 more source

Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer

Heliyon, 2020
Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar, Yasmin Vahidi, Maryam Fakhimi, Ardalan Asadollahpour, Nasrollah Erfani, Zahra Faghih   +5 more
doaj   +1 more source

Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC

JTO Clinical and Research Reports, 2021
Introduction: This study investigates the immune profile of the primary lung tumors and the corresponding brain metastasis from patients with NSCLC using multiplex fluorescence immunohistochemistry.
Daiki Ikarashi, MD, PhD, Tamio Okimoto, MD, PhD, Takehito Shukuya, MD, PhD, Hiroko Onagi, MD, Takuo Hayashi, MD, PhD, Sara L. Sinicropi-Yao, PhD, Joseph M. Amann, PhD, Tetsuya Nakatsura, MD, PhD, Shigehisa Kitano, MD, PhD, David P. Carbone, MD, PhD   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Immunohistochemical Evaluation of CD3, CD4, CD8, and CD20 in Decidual and Trophoblastic Tissue Specimens of Patients with Recurrent Pregnancy Loss

Clinics and Practice, 2022
Recurrent miscarriages affect up to 5% of couples. CD3+ (T-lymphocytes), CD4+ (helper T-lymphocytes), CD8+ (cytotoxic T-lymphocytes), and CD20+ (B-lymphocytes) cells may participate in the pathophysiology of recurrent pregnancy loss (RPL).
Dimitrios Kavvadas, Sofia Karachrysafi, Pinelopi Anastasiadou, Asimoula Kavvada, Stella Fotiadou, Angeliki Papachristodoulou, Theodora Papamitsou, Antonia Sioga   +7 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source