Results 41 to 50 of about 15,816,019 (291)

Analysis of WB band type and the first test results of CD4+ T lymphocytes in HIV-1 antibody positive patients

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To analyze the WB band and the first test results of CD4+ T lymphocytes in 226 patients with HIV-1 antibody positive in order to reveal the WB pattern and to explore disease progression and immune status, providing the basis for classification
Miaolin HUANG, Junhe LIANG, Jianqi ZOU, Minchao FENG, Hongzhu CAI, Xi'an ZHONG   +5 more
doaj   +1 more source

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
de Lara, C, Zhang Yan, Hegedus Andrea, Karoliina Laamanen, Derek Macallan, de Lara Catherine, Peter Beverley, Laamanen Karoliina, Catherine de Lara (339229), Karoliina Laamanen (233571), Yan Zhang (8098), Worth Andrew, Laamanen, K, Andrew Worth, Andrea Hegedus, Hegedus, A, Beverley Peter, Andrew Worth (404365), Worth, A, Zhang, Y, Macallan, D, Andrea Hegedus (404366), Peter Beverley (404367), Macallan Derek, Beverley, P, Yan Zhang, Catherine de Lara, Derek Macallan (404368)   +27 more
core   +1 more source

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy [PDF]

, 2004
Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with
Jamie G. Evans, Gary Warnes, Mauri, C, Isenberg, DA, Warnes, G, Samantha Moore, Michael R. Ehrenstein, Evans, JG, Moore, S, Singh, A, David A. Isenberg, Claudia Mauri, Ehrenstein, MR, Animesh Singh   +13 more
core   +1 more source

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]

, 1987
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by ...
Reddehase, Matthias J., Münch, Konrad, Koszinowski, Ulrich H., Mutter, Wolfgang, Bühring, Hans-Jörg   +4 more
core   +1 more source

Regulatory T cells in children with recently diagnosed type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2012
Background: Regulatory T cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes (T1D).
Asmaa Mohamed Zahran, Khalid Ibrahem Elsayh, Kotb Abbass Metwalley   +2 more
doaj   +1 more source

Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer

Heliyon, 2020
Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar, Yasmin Vahidi, Maryam Fakhimi, Ardalan Asadollahpour, Nasrollah Erfani, Zahra Faghih   +5 more
doaj   +1 more source

Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC

JTO Clinical and Research Reports, 2021
Introduction: This study investigates the immune profile of the primary lung tumors and the corresponding brain metastasis from patients with NSCLC using multiplex fluorescence immunohistochemistry.
Daiki Ikarashi, MD, PhD, Tamio Okimoto, MD, PhD, Takehito Shukuya, MD, PhD, Hiroko Onagi, MD, Takuo Hayashi, MD, PhD, Sara L. Sinicropi-Yao, PhD, Joseph M. Amann, PhD, Tetsuya Nakatsura, MD, PhD, Shigehisa Kitano, MD, PhD, David P. Carbone, MD, PhD   +9 more
doaj   +1 more source

Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]

, 2004
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley, Macallan, DC, Griffin, GE, George E. Griffin, Andrew T. Worth, Derek C. Macallan, Wallace, Diana, Diana Wallace, Ghattas, Hala, Zhang, Yan, Griffin, George E, Macallan, Derek C, Zhang, Y, Ghattas, H, Beverley, Peter CL, Tough, David F, Hala Ghattas, Tough, DF, David F. Tough, De Lara, C, De Lara, Catherine, Beverley, PC, Yan Zhang, Catherine de Lara, Wallace, D, Worth, Andrew T, Worth, AT   +26 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets [PDF]

, 2006
The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals.
Maurer, Konrad, Schindowski, Katharina, Frölich, Lutz, Eckert, Anne, Müller, Walter E.   +4 more
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