Results 21 to 30 of about 30,642,264 (240)

Spatial technologies to evaluate the HIV-1 reservoir and its microenvironment in the lymph node [PDF]

mBio
The presence of the HIV-1 reservoir, a group of immune cells that contain intact, integrated, and replication-competent proviruses, is a major challenge to cure HIV-1.
Fatima Zaman, Melissa L. Smith, Ashwin Balagopal, Christine M. Durand, Andrew D. Redd, Aaron A. R. Tobian   +5 more
doaj   +2 more sources

HIV-1 Compartmentalization and Reservoir Formation [PDF]

, 2020
With over 37 million people living with HIV-1, and over one million new infections occurring each year, HIV-1 continues to be a significant public health burden.
Council, Olivia
core   +2 more sources

Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir [PDF]

The Journal of Clinical Investigation
BACKGROUND Antiretroviral therapy (ART) has improved the clinical management of HIV-1 infection. However, little is known about how the latest ART recommendations affect the heterogeneity of the HIV-1 reservoir size.METHODS We used a complete statistical
Irene González-Navarro, Víctor Urrea, Cristina Gálvez, Maria del Carmen Garcia-Guerrero, Sara Morón-López, Maria C. Puertas, Eulàlia Grau, Beatriz Mothe, Lucía Bailón, Cristina Miranda, Felipe García, Lorna Leal, Linos Vandekerckhove, Vincent C. Marconi, Rafick P. Sekaly, Bonaventura Clotet, Javier Martinez-Picado, Maria Salgado, the NIH Reversing Immune Dysfunction for HIV-1 Eradication (RID-HIV) Collaboratory Group   +18 more
doaj   +2 more sources

Specific quantification of inducible HIV-1 reservoir by RT-LAMP [PDF]

Communications Medicine
Background Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be safely interrupted.
Tanvir Hossain, Cynthia Lungu, Sten de Schrijver, Mamokoena Kuali, Raquel Crespo, Nicole Reddy, Ayanda Ngubane, Tsung Wai Kan, Kavidha Reddy, Shringar Rao, Robert-Jan Palstra, Paradise Madlala, Thumbi Ndung’u, Tokameh Mahmoudi   +13 more
doaj   +2 more sources

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

Viruses, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Priya Khetan, Yufeng Liu, Adit Dhummakupt, Deborah Persaud   +3 more
doaj   +1 more source

Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment [PDF]

, 2020
BACKGROUND: The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay ...
Bachmann, Nadine, Battegay, Manuel, Yerly, Sabine, Roger D. Kouyos, Guenthard, Huldrych F., Perreau, M., Vongrad, Valentina, Niko Beerenwinkel, Swiss HIV Cohort Study,, Von Siebenthal, Chantal, Battegay, M., Jürg Böni, Valentina Vongrad, Kathrin Neumann, Böni, J., Swiss HIV Cohort Study, Teja Turk, Jacques Fellay, Günthard, Huldrych F., Schmid, Patrick, Yik Lim Kok, Andri Rauch, Neumann, Kathrin, Metzner, Karin J, Sonali Parbhoo, Bogojeska, Jasmina, Metzner, K.J., Schmid, P., Klimkait, Thomas, Fellay, Jacques, Roth, V., Thorball, C.W., Kouyos, R.D., Matthieu Perreau, Von Siebenthal, C., Beerenwinkel, N., Yerly, S., Alessandro Borghesi, Chantal Von Siebenthal, Yerly Ferrillo, Sabine, Mario Wieser, Wieser, M., Bernasconi, E., Vongrad, V., Boeni, Juerg, Patrick Schmid, Enos Bernasconi, Günthard, Huldrych F, Kouyos, Roger D., Parbhoo, Sonali, Beerenwinkel, Niko, Parbhoo, S., Cavassini, M., Böni, Jürg, Bogojeska, J., Thomas Klimkait, Christian W. Thorball, Fellay, J., Rauch, A., Kok, Y.L., Bernasconi, Enos, Huldrych F. Günthard, Kouyos, Roger D, Roth, Volker, Nadine Bachmann, Sabine Yerly, Borghesi, Alessandro, Kok, Yik Lim, Rauch, Andri, Borghesi, A., Neumann, K., Karin J. Metzner, Thorball, Christian W, Günthard, H.F., Manuel Battegay, Bachmann, N., Klimkait, T., Turk, T., Thorball, Christian W., Metzner, Karin J., Turk, Teja, Perreau, Matthieu, Wieser, Mario, Jasmina Bogojeska, Volker Roth, Matthias Cavassini, Cavassini, Matthias   +86 more
core   +2 more sources

Hiding in plain sight – platelets, the silent carriers of HIV-1

Platelets, 2021
There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer, Tina M. Weatherby, Brooks I. Mitchell, Ivo N. SahBandar, Thomas A. Premeaux, D’Antoni Michelle L., Cristhian A. Gutierrez-Huerta, Tiffany M. Powell-Wiley, Timothy R. Brown, William A. Boisvert, Cecilia M. Shikuma, Lishomwa C. Ndhlovu   +11 more
doaj   +1 more source

Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir [PDF]

Cell Host & Microbe, 2021
Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that are otherwise occluded on the unliganded viral envelope (Env). Combining CD4mc with two families of CD4-induced (CD4i) antibodies, which are frequently found in plasma of HIV-1 ...
Jyothi K, Rajashekar, Jonathan, Richard, Jagadish, Beloor, Jérémie, Prévost, Sai Priya, Anand, Guillaume, Beaudoin-Bussières, Liang, Shan, Dietmar, Herndler-Brandstetter, Gabrielle, Gendron-Lepage, Halima, Medjahed, Catherine, Bourassa, Fleur, Gaudette, Irfan, Ullah, Kelly, Symmes, Andrew, Peric, Emily, Lindemuth, Frederic, Bibollet-Ruche, Jun, Park, Hung-Ching, Chen, Daniel E, Kaufmann, Beatrice H, Hahn, Joseph, Sodroski, Marzena, Pazgier, Richard A, Flavell, Amos B, Smith, Andrés, Finzi, Priti, Kumar   +26 more
openaire   +2 more sources

Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure [PDF]

Nature Reviews Microbiology
Mathias Lichterfeld, Wei-Wei Sun, Xu G Yu   +2 more
exaly   +2 more sources