Results 21 to 30 of about 34,607 (204)

Heterogeneity of HIV-1 latent reservoirs

Chinese Medical Journal, 2020
Abstract Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses.
Jia-Cong Zhao, Kai Deng, Peng Lyu, Xin Chen.   +3 more
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Targeting the Latent Reservoir for HIV-1 [PDF]

Immunity, 2018
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within weeks of treatment interruption. The major barrier to a cure is a small pool of resting memory CD4+ T cells that harbor latent HIV-1 proviruses.
Srona, Sengupta, Robert F, Siliciano
openaire   +2 more sources

Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure

Cells, 2021
Effective antiretroviral therapy has led to significant human immunodeficiency virus type 1 (HIV-1) suppression and improvement in immune function. However, the persistence of integrated proviral DNA in latently infected reservoir cells, which drive ...
Grant R. Campbell, Stephen A. Spector
doaj   +1 more source

HIV-1 Latent Reservoir: Size Matters [PDF]

Future Virology, 2016
More than 35 million people remain infected with HIV-1. Upon antiretroviral therapy cessation, HIV-1-positive individuals systematically fail to achieve sustained virological remission, revealing the presence of a reservoir. This reservoir takes into account anatomical sanctuaries where HIV-1 continues to replicate, and latently infected cells also ...
Hodel, F., Patxot, M., Snäkä, T., Ciuffi, A.   +3 more
openaire   +4 more sources

Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1 [PDF]

Science, 2006
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir.
Keele, B. F., Van Heuverswyn, F., Li, Y.Y., Bailes, E., Takehisa, J., Santiago, M. L., Bibollet Ruche, F., Chen, Y. L., Wain, L. V., /Liégeois, Florian, Loul, S., Mpoudi Ngolé, E., Bienvenue, Y., /Delaporte, Eric, Brookfield, J. F. Y., Sharp, P. M., Shaw, G. M., /Peeters, Martine, Hahn, B. H.   +18 more
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Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients

Retrovirology, 2007
Background The presence of HIV-1 preintegration reservoir was assessed in an in vitro experimental model of latent HIV-1 infection, and in patients treated or not with highly active antiretroviral therapy (HAART).
Baillat Vincent, Mettling Clement, Tuaillon Edouard, Al Tabaa Yassine, Petitjean Gaël, Reynes Jacques, Segondy Michel, Vendrell Jean   +7 more
doaj   +1 more source

B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 ⁺ T Cells: Implications for the Viral Reservoir

mBio, 2021
The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-competent
Abigail Gerberick, Diana C. DeLucia, Paolo Piazza, Mounia Alaoui-El-Azher, Charles R. Rinaldo, Nicolas Sluis-Cremer, Giovanna Rappocciolo   +6 more
doaj   +1 more source

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Frontiers in Immunology, 2022
B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and are key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) and other viral infections, thereby ...
Monica D. Reece, Colin Song, Sarah C. Hancock, Susan Pereira Ribeiro, Deanna A. Kulpa, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano   +9 more
doaj   +1 more source

Insights into the HIV-1 Latent Reservoir and Strategies to Cure HIV-1 Infection

Disease Markers, 2022
Since the first discovery of human immunodeficiency virus 1 (HIV-1) in 1983, the targeted treatment, antiretroviral therapy (ART), has effectively limited the detected plasma viremia below a very low level and the technique has been improved rapidly.
Ruojing Bai, Shiyun Lv, Hao Wu, Lili Dai
openaire   +2 more sources

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

mBio, 2022
Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute
Julia Rubione, Paula S. Pérez, Alejandro Czernikier, Gabriel A. Duette, Federico Pehuen Pereyra Gerber, Jimena Salido, Martina P. Fabiano, Yanina Ghiglione, Gabriela Turk, Natalia Laufer, Alejandro J. Cagnoni, Juan M. Pérez Sáez, Joaquín P. Merlo, Carla Pascuale, Juan C. Stupirski, Omar Sued, Manuel Varas-Godoy, Sharon R. Lewin, Karina V. Mariño, Gabriel A. Rabinovich, Matías Ostrowski   +20 more
doaj   +1 more source