The Interplay of HIV-1 and Macrophages in Viral Persistence [PDF]
Frontiers in Microbiology, 2021 HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the powerful effects of highly active antiretroviral therapies (HAART ...
Chynna M. Hendricks +3 more
doaj +2 more sources
Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence
Viruses, 2020 While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts +4 more
doaj +3 more sources
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence [PDF]
Immunity, 2023 Yulong Wei +2 more
exaly +2 more sources
HIV persistence in tissues on dolutegravir-based therapy is not associated with resistance mutations to dolutegravir. [PDF]
Commun Med (Lond)Background Relatively few studies have investigated HIV-1 persistence in tissues, especially in healthy people-living-with-HIV-1 (PLWH) on a successful antiretroviral regimen containing second generation integrase inhibitors.
Mchantaf G +16 more
europepmc +2 more sources
Hiding in plain sight – platelets, the silent carriers of HIV-1
Platelets, 2021 There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer +11 more
doaj +1 more source
Viruses, 2022 Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients.
Laura E. P. Huyveneers +22 more
doaj +1 more source
An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes
Scientific Reports, 2021 Human immunodeficiency virus-1 (HIV-1) persistence in the presence of antiretroviral therapy (ART) has halted the development of curative strategies. Measuring HIV persistence is complex due to the low frequency of cells containing virus in vivo. Most of
Callie Levinger +6 more
doaj +1 more source
The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure
Journal of Virus Eradication, 2016 The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome.
Maja Kiselinova +2 more
doaj +1 more source
Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
Scientific Reports, 2021 HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed ...
Amina Ait-Ammar +12 more
doaj +1 more source
Robust CAR-T memory formation and function via hematopoietic stem cell delivery.
PLoS Pathogens, 2021 Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection.
Anjie Zhen +9 more
doaj +1 more source