Epigenetic Mechanisms of HIV-1 Persistence [PDF]
Vaccines, 2021 Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized ...
Roxane Verdikt +2 more
exaly +14 more sources
HIV-1 Persistence in Children during Suppressive ART [PDF]
Viruses, 2021 There is a growing number of perinatally HIV-1-infected children worldwide who must maintain life-long ART. In early life, HIV-1 infection is established in an immunologically inexperienced environment in which maternal ART and immune dynamics during ...
Mary Grace Katusiime +2 more
exaly +7 more sources
The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence? [PDF]
Viruses, 2021 Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure.
Ben Berkhout +2 more
exaly +6 more sources
The Role of Macrophages in HIV-1 Persistence and Pathogenesis [PDF]
Frontiers in Microbiology, 2019 Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV-1 infected cells and the virus persists in cellular reservoirs.
Zita Kruize, Neeltje A. Kootstra
doaj +8 more sources
Humanized Mice for Studies of HIV-1 Persistence and Elimination [PDF]
Pathogens, 2023 A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is the persistence of latent viral infections in the cells and tissue compartments of an infected human host. Latent HIV-1 proviral DNA persists in resting memory CD4+
Chen Zhang +5 more
doaj +6 more sources
Episomal HIV-1 DNA and its relationship to other markers of HIV-1 persistence [PDF]
Retrovirology, 2018 Reverse transcription of HIV-1 results in the generation of a linear cDNA that serves as the precursor to the integrated provirus. Other classes of extrachromosomal viral cDNA molecules can be found in acutely infected cells including the 1-LTR and 2-LTR
Javier Martinez-Picado +3 more
doaj +8 more sources
The Interplay of HIV-1 and Macrophages in Viral Persistence [PDF]
Frontiers in Microbiology, 2021 HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the powerful effects of highly active antiretroviral therapies (HAART ...
Chynna M. Hendricks +3 more
doaj +6 more sources
Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation [PDF]
PLoS Pathogens, 2017 Antiretroviral therapy (ART) reduces levels of HIV-1 and immune activation but both can persist despite clinically effective ART. The relationships among pre-ART and on-ART levels of HIV-1 and activation are incompletely understood, in part because prior
Ann Collier +2 more
exaly +3 more sources
Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence [PDF]
Viruses, 2020 While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts +4 more
doaj +6 more sources
Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune cells that play a critical role in controlling viral infections and ...
Geoffrey T. Ivison +27 more
doaj +2 more sources