Epigenetic Mechanisms of HIV-1 Persistence [PDF]
Vaccines, 2021 Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized ...
Roxane Verdikt +2 more
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HIV-1 Persistence in Children during Suppressive ART [PDF]
Viruses, 2021 There is a growing number of perinatally HIV-1-infected children worldwide who must maintain life-long ART. In early life, HIV-1 infection is established in an immunologically inexperienced environment in which maternal ART and immune dynamics during ...
Mary Grace Katusiime +3 more
doaj +7 more sources
The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence? [PDF]
Viruses, 2021 Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure.
Alexander O. Pasternak, Ben Berkhout
doaj +4 more sources
The Role of Macrophages in HIV-1 Persistence and Pathogenesis [PDF]
Frontiers in Microbiology, 2019 Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV-1 infected cells and the virus persists in cellular reservoirs.
Zita Kruize, Neeltje A. Kootstra
doaj +6 more sources
Humanized Mice for Studies of HIV-1 Persistence and Elimination [PDF]
Pathogens, 2023 A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is the persistence of latent viral infections in the cells and tissue compartments of an infected human host. Latent HIV-1 proviral DNA persists in resting memory CD4+
Chen Zhang +5 more
doaj +4 more sources
Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation. [PDF]
PLoS Pathogens, 2017 Antiretroviral therapy (ART) reduces levels of HIV-1 and immune activation but both can persist despite clinically effective ART. The relationships among pre-ART and on-ART levels of HIV-1 and activation are incompletely understood, in part because prior
Rajesh T Gandhi +13 more
doaj +3 more sources
Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune cells that play a critical role in controlling viral infections and ...
Geoffrey T. Ivison +27 more
doaj +2 more sources
The Rectal Mucosal Myeloid Niche in HIV-1 Persistence: Reservoir Support, Viral Sequestration, and Therapeutic Opportunities [PDF]
VirusesPersistent HIV-1 reservoirs remain a major barrier to a durable functional cure despite long-term suppressive antiretroviral therapy. Although resting memory CD4+ T cells constitute the best-characterized cellular reservoir, tissue microenvironments ...
Hanyi Zhang +3 more
doaj +2 more sources
Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence [PDF]
Contemporary Clinical Trials Communications, 2021 Background: Opioid use disorder (OUD) negatively impacts the HIV continuum of care for persons living with HIV (PLH). Medication treatment for OUD (MOUD) may have differential biological effects in individuals with HIV and OUD.
Alysse Schultheis +6 more
doaj +2 more sources
The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells [PDF]
The Journal of Clinical Investigation, 2022 Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted.
Gabriel Duette +22 more
doaj +2 more sources