mBio, 2021 Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez +6 more
doaj +1 more source
Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds [PDF]
, 2015 Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time.
Jürg Böni (36157) +55 more
core +1 more source
Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso. [PDF]
, 2006 Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates ...
Costes-Martineau, V +30 more
core +1 more source
Discontinuation of secondary prophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection who have a response to antiretroviral therapy [PDF]
, 2001 Background: Patients with human immunodeficiency virus (HIV) infection and a history of Pneumocystis carinii pneumonia are at high risk for relapse if they are not given secondary prophylaxis. Whether secondary prophylaxis against P.
H. Furrer +36 more
core +1 more source
Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]
, 2013 BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack +21 more
core +1 more source
THE PERSISTENCE OF HIV-1 SPREADING IN MSM POPULATION IN CHINA
Journal of Applied Analysis & Computation, 2019 Summary: In this work, we develop and analyze mathematical models for the dynamics about the evolution of HIV/AIDS in men who have sex with men in China. We focus on the analyses of the basic reproduction number \(R_0\) and the persistence of infection.
Li, Yan, Cheng, Jinjin, Lou, Jie
openaire +2 more sources
Frontiers in Immunology, 2018 Immunodeficient mice transplanted with human cell populations or tissues, also known as human immune system (HIS) mice, have emerged as an important and versatile tool for the in vivo study of human immunodeficiency virus-type 1 (HIV-1) pathogenesis ...
Teresa H. Evering, Moriya Tsuji
doaj +1 more source
The Interplay of HIV and Autophagy in Early Infection
Frontiers in Microbiology, 2021 HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health communities to understand viral infection, to design new drugs or to improve existing ones, as well as to develop advanced therapies and vaccine designs for ...
Romina Cabrera-Rodríguez +8 more
doaj +1 more source
Outcomes for efavirenz versus nevirapine-containing regimens for treatment of HIV-1 infection: a systematic review and meta-analysis. [PDF]
, 2013 INTRODUCTION: There is conflicting evidence and practice regarding the use of the non-nucleoside reverse transcriptase inhibitors (NNRTI) efavirenz (EFV) and nevirapine (NVP) in first-line antiretroviral therapy (ART). METHODS: We systematically reviewed
Pillay, Prinitha +16 more
core +1 more source
HIV-1 Proviral Transcription and Latency in the New Era
Viruses, 2020 Three decades of extensive work in the HIV field have revealed key viral and host cell factors controlling proviral transcription. Various models of transcriptional regulation have emerged based on the collective information from in vitro assays and work
Ashutosh Shukla +2 more
doaj +1 more source