Results 31 to 40 of about 30,666,235 (182)

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection [PDF]

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Pellegrino, P, Groppelli, E, Elisabetta Groppelli (258517), Jolly, C, Ian Williams (208301), Changwang Zhang (716808), Persephone Borrow, Borrow, P, Chain, BM, Benjamin M Chain, Zhou, S, Zhou, Shi, Groppelli, Elisabetta, Persephone Borrow (194557), Ian Williams, Zhang, Changwang, Pellegrino, Pierre, Changwang Zhang, Jolly, Clare, Elisabetta Groppelli, Shi Zhou, Clare Jolly (207781), Pierre Pellegrino (208300), Benjamin M. Chain (154754), Pierre Pellegrino, Williams, Ian, Borrow, Persephone, Shi Zhou (452014), Zhang, C, Chain, Benjamin M., Williams, I, Clare Jolly   +31 more
core   +1 more source

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir

Retrovirology, 2018
Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses.
Zheng Wang, Francesco R. Simonetti, Robert F. Siliciano, Gregory M. Laird   +3 more
doaj   +1 more source

Robust CAR-T memory formation and function via hematopoietic stem cell delivery.

PLoS Pathogens, 2021
Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection.
Anjie Zhen, Mayra A Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S Y Chen, Otto O Yang, Jerome A Zack, Scott G Kitchen   +9 more
doaj   +1 more source

Impact of chemotherapy for HIV-1 related lymphoma on residual viremia and cellular HIV-1 DNA in patients on suppressive antiretroviral therapy. [PDF]

PLoS ONE, 2014
The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor.
Anthony R Cillo, Supriya Krishnan, Deborah K McMahon, Ronald T Mitsuyasu, Michael F Para, John W Mellors   +5 more
doaj   +1 more source

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
Van de Perre, P, James Ndirangu, Ndirangu James, Ruth M. Bland, Van de Perre Philippe, Ruth M Bland, Thorne, C., Danaviah, S, Thorne Claire, Newell Marie-Louise, Newell, M.-L., Viljoen, J., Ndirangu, J., Newell, M-L, Thorne, C, Van de Perre, P., Danaviah Siva, Bland, R.M., Philippe Van de Perre, Viljoen, J, Marie-Louise Newell, Ndirangu, J, Claire Thorne, Bland, RM, Danaviah, S., Siva Danaviah, Viljoen Johannes, Bland Ruth M., Johannes Viljoen   +28 more
core   +1 more source

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques

Retrovirology, 2023
A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV infection fail to recapitulate viral persistence in the CNS without encephalitis or fail to ...
Rachel M. Podgorski, Jake A. Robinson, Mandy D. Smith, Suvadip Mallick, Huaqing Zhao, Ronald S. Veazey, Dennis L. Kolson, Katharine J. Bar, Tricia H. Burdo   +8 more
doaj   +1 more source

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
doaj   +1 more source

Cervicovaginal HIV-1 shedding in women taking antiretroviral therapy in Burkina Faso: a longitudinal study. [PDF]

, 2013
BACKGROUND: Antiretroviral therapy (ART) reduces transmission of HIV-1. However, genital HIV-1 can be detected in patients on ART. We analyzed factors associated with genital HIV-1 shedding among high-risk women on ART in Burkina Faso.
Kania, Dramane, Segondy, Michel, Mabey, David, Meda, Nicolas, Weiss, Helen A, Vickerman, Peter, van de Perre, Philippe, Nagot, Nicolas, Low, Andrea, Mayaud, Philippe, ?, ?, Low, Andrea J, Pillay, Deenan, Konate, Issouf, Yerelon Study Group, Weiss, Helen, Pillay, Deenan,   +16 more
core   +1 more source

Nonsuppressible HIV-1 viremia: a reflection of how the reservoir persists [PDF]

Journal of Clinical Investigation, 2020
Antiretroviral therapy (ART) generally reduces plasma HIV to undetectable levels, although virus persists in latently infected CD4+ T cells. In some individuals, viremia remains detectable despite adherence to ART and the absence of drug resistance mutations. In this issue of the JCI, Halvas et al.
Janet D. Siliciano, Robert F. Siliciano
openaire   +2 more sources

Human Immune System Mice for the Study of Human Immunodeficiency Virus-Type 1 Infection of the Central Nervous System

Frontiers in Immunology, 2018
Immunodeficient mice transplanted with human cell populations or tissues, also known as human immune system (HIS) mice, have emerged as an important and versatile tool for the in vivo study of human immunodeficiency virus-type 1 (HIV-1) pathogenesis ...
Teresa H. Evering, Moriya Tsuji
doaj   +1 more source