Results 21 to 30 of about 121,361 (282)

Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells

Viruses, 2022
Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients.
Laura E. P. Huyveneers, Anke Bruns, Arjen Stam, Pauline Ellerbroek, Dorien de Jong, Noémi A. Nagy, Stephanie B. H. Gumbs, Kiki Tesselaar, Kobus Bosman, Maria Salgado, Gero Hütter, Lodewijk A. A. Brosens, Mi Kwon, Jose Diez Martin, Jan T. M. van der Meer, Theun M. de Kort, Asier Sáez-Cirión, Julian Schulze zur Wiesch, Jaap Jan Boelens, Javier Martinez-Picado, Jürgen H. E. Kuball, Annemarie M. J. Wensing, Monique Nijhuis   +22 more
doaj   +1 more source

Persistent HIV-1 replication during antiretroviral therapy [PDF]

Current Opinion in HIV and AIDS, 2016
The present review will highlight some of the recent findings regarding the capacity of HIV-1 to replicate during antiretroviral therapy (ART).Although ART is highly effective at inhibiting HIV replication, it is not curative. Several mechanisms contribute to HIV persistence during ART, including HIV latency, immune dysfunction, and perhaps persistent ...
Martinez-Picado, Javier, Deeks, Steven G
openaire   +5 more sources

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization [PDF]

PLOS Pathogens, 2023
Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction o f infectivity at maximum neutralization, which may also influence ...
Rajesh P. Ringe, Philippe Colin, Gabriel Ozorowski, Joel D. Allen, Anila Yasmeen, Gemma E. Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P. Moore, Andrew B. Ward, Max Crispin, P. J. Klasse   +13 more
openaire   +4 more sources

An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes

Scientific Reports, 2021
Human immunodeficiency virus-1 (HIV-1) persistence in the presence of antiretroviral therapy (ART) has halted the development of curative strategies. Measuring HIV persistence is complex due to the low frequency of cells containing virus in vivo. Most of
Callie Levinger, JNatalie Howard, Jie Cheng, Pingtao Tang, Amit Joshi, Marta Catalfamo, Alberto Bosque   +6 more
doaj   +1 more source

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure

Journal of Virus Eradication, 2016
The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome.
Maja Kiselinova, Ward De Spiegelaere, Linos Vandekerckhove   +2 more
doaj   +1 more source

Cellular Determinants of HIV Persistence on Antiretroviral Therapy [PDF]

, 2018
International audienceThe era of antiretroviral therapy has made HIV-1 infection a manageable chronic disease for those with access to treatment. Despite treatment, virus persists in tissue reservoirs seeded with long-lived infected cells that are ...
Anastassia Mikhailova, Valle-Casuso, Jose Carlos, Jose Carlos Valle-Casuso, Asier Sáez-Cirión, Mikhailova, Anastassia, Saez-Cirion, Asier   +5 more
core   +1 more source

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage

Scientific Reports, 2021
HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed ...
Amina Ait-Ammar, Maxime Bellefroid, Fadoua Daouad, Valérie Martinelli, Jeanne Van Assche, Clémentine Wallet, Anthony Rodari, Marco De Rovere, Birthe Fahrenkrog, Christian Schwartz, Carine Van Lint, Virginie Gautier, Olivier Rohr   +12 more
doaj   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence [PDF]

Current HIV Research, 2008
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the
Aikaterini, Alexaki, Yujie, Liu, Brian, Wigdahl   +2 more
openaire   +2 more sources

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection [PDF]

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Pellegrino, P, Groppelli, E, Elisabetta Groppelli (258517), Jolly, C, Ian Williams (208301), Changwang Zhang (716808), Persephone Borrow, Borrow, P, Chain, BM, Benjamin M Chain, Zhou, S, Zhou, Shi, Groppelli, Elisabetta, Persephone Borrow (194557), Ian Williams, Zhang, Changwang, Pellegrino, Pierre, Changwang Zhang, Jolly, Clare, Elisabetta Groppelli, Shi Zhou, Clare Jolly (207781), Pierre Pellegrino (208300), Benjamin M. Chain (154754), Pierre Pellegrino, Williams, Ian, Borrow, Persephone, Shi Zhou (452014), Zhang, C, Chain, Benjamin M., Williams, I, Clare Jolly   +31 more
core   +2 more sources