Results 21 to 30 of about 120,919 (245)

Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence

Nature Communications
Initiation of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) has been proposed to limit the formation of HIV-1 reservoirs. However, it remains unknown whether temporary ART initiated during PHI has a long-term effect on viral ...
Alexander O. Pasternak, Pien M. van Paassen, Yara L. Verschoor, Jelmer Vroom, Karel A. van Dort, Irma Maurer, Marlous L. Grijsen, Ferdinand W. Wit, Godelieve J. de Bree, Neeltje A. Kootstra, Jan M. Prins, Ben Berkhout   +11 more
doaj   +2 more sources

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
Van de Perre, P, James Ndirangu, Ndirangu James, Ruth M. Bland, Van de Perre Philippe, Ruth M Bland, Thorne, C., Danaviah, S, Thorne Claire, Newell Marie-Louise, Newell, M.-L., Viljoen, J., Ndirangu, J., Newell, M-L, Thorne, C, Van de Perre, P., Danaviah Siva, Bland, R.M., Philippe Van de Perre, Viljoen, J, Marie-Louise Newell, Ndirangu, J, Claire Thorne, Bland, RM, Danaviah, S., Siva Danaviah, Viljoen Johannes, Bland Ruth M., Johannes Viljoen   +28 more
core   +1 more source

Cervicovaginal HIV-1 shedding in women taking antiretroviral therapy in Burkina Faso: a longitudinal study. [PDF]

, 2013
BACKGROUND: Antiretroviral therapy (ART) reduces transmission of HIV-1. However, genital HIV-1 can be detected in patients on ART. We analyzed factors associated with genital HIV-1 shedding among high-risk women on ART in Burkina Faso.
Kania, Dramane, Segondy, Michel, Mabey, David, Meda, Nicolas, Weiss, Helen A, Vickerman, Peter, van de Perre, Philippe, Nagot, Nicolas, Low, Andrea, Mayaud, Philippe, ?, ?, Low, Andrea J, Pillay, Deenan, Konate, Issouf, Yerelon Study Group, Weiss, Helen, Pillay, Deenan,   +16 more
core   +1 more source

Impact of chemotherapy for HIV-1 related lymphoma on residual viremia and cellular HIV-1 DNA in patients on suppressive antiretroviral therapy. [PDF]

PLoS ONE, 2014
The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor.
Anthony R Cillo, Supriya Krishnan, Deborah K McMahon, Ronald T Mitsuyasu, Michael F Para, John W Mellors   +5 more
doaj   +1 more source

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques

Retrovirology, 2023
A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV infection fail to recapitulate viral persistence in the CNS without encephalitis or fail to ...
Rachel M. Podgorski, Jake A. Robinson, Mandy D. Smith, Suvadip Mallick, Huaqing Zhao, Ronald S. Veazey, Dennis L. Kolson, Katharine J. Bar, Tricia H. Burdo   +8 more
doaj   +1 more source

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
doaj   +1 more source

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir

Retrovirology, 2018
Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses.
Zheng Wang, Francesco R. Simonetti, Robert F. Siliciano, Gregory M. Laird   +3 more
doaj   +1 more source

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds [PDF]

, 2015
Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time.
Jürg Böni (36157), Yerly, Sabine, Wan-Lin Yang (709662), Christos Petropoulos (709664), Shilaih, Mohaned, Vincent Aubert (297526), Petropoulos, C., Jürg Böni, Huldrych F. Günthard (173082), Böni, J., Shilaih, M., Wan-Lin Yang, Mohaned Shilaih (709663), Petropoulos, Christos J., Bonhoeffer, S., Roger D Kouyos, Klimkait, Thomas, Sebastian Bonhoeffer, Aubert, Vincent, Kouyos, R.D., Sabine Yerly (82534), Sebastian Bonhoeffer (20372), Swiss HIV Cohort Study (SHCS), Bonhoeffer, Sebastian, Scherrer, Alexandra U, Yerly, S., Yang, W.L., Yerly Ferrillo, Sabine, Swiss, H. I. V. Cohort Study, Hinkley, T., Thomas Klimkait (178911), Günthard, Huldrych F, Kouyos, Roger D., Yang, Wan-Lin, Scherrer, Alexandra U., Alexandra U Scherrer, Mohaned Shilaih, Trevor Hinkley, Aubert, V., Böni, Jürg, Thomas Klimkait, Petropoulos, Christos, Roger D. Kouyos (161982), Alexandra U. Scherrer (214775), Gunthard, Huldrych F., Kouyos, Roger D, Trevor Hinkley (82390), Sabine Yerly, Scherrer, A.U., Günthard, H.F., Klimkait, T., Christos Petropoulos, Vincent Aubert, Bonhoeffer, Sebastian; id_orcid, Hinkley, Trevor, Huldrych F Günthard   +55 more
core   +1 more source

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso. [PDF]

, 2006
Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates ...
Costes-Martineau, V, Van de Perre, P, Van de Perre, Philippe, P Van de Perre, P Mayaud, Nagot, N., M-N Didelot-Rousseau, Didelot-Rousseau, Marie-Noëlle, H A Weiss, Nagot, N, Weiss, H. A., M Segondy, A Ouedraogo, V Costes-Martineau, I Konate, Ouedraogo, A., Konate, I, Konate, I., Segondy, Michel, Weiss, HA, X Vallès, Mayaud, P, Didelot-Rousseau, M-N, Mayaud, P., Yerelon Study Group, Segondy, M, Vallès, X, Costes Martineau, V., Ouedraogo, A, N Nagot, Valles, X.   +30 more
core   +1 more source