Results 21 to 30 of about 30,666,235 (182)
Latency and viral persistence in HIV-1 infection [PDF]
Journal of Clinical Investigation, 2000 HIV-1 infection can be controlled with combinations of antiretroviral drugs, an approach known as highly active antiretroviral therapy (HAART). In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins.
J D, Siliciano, R F, Siliciano
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Viruses, 2022 Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients.
Laura E. P. Huyveneers +22 more
doaj +1 more source
An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes
Scientific Reports, 2021 Human immunodeficiency virus-1 (HIV-1) persistence in the presence of antiretroviral therapy (ART) has halted the development of curative strategies. Measuring HIV persistence is complex due to the low frequency of cells containing virus in vivo. Most of
Callie Levinger +6 more
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Persistent HIV-1 replication during antiretroviral therapy [PDF]
Current Opinion in HIV and AIDS, 2016 The present review will highlight some of the recent findings regarding the capacity of HIV-1 to replicate during antiretroviral therapy (ART).Although ART is highly effective at inhibiting HIV replication, it is not curative. Several mechanisms contribute to HIV persistence during ART, including HIV latency, immune dysfunction, and perhaps persistent ...
Martinez-Picado, Javier, Deeks, Steven G
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Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization [PDF]
PLOS Pathogens, 2023 Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction o f infectivity at maximum neutralization, which may also influence ...
Rajesh P. Ringe +13 more
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The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure
Journal of Virus Eradication, 2016 The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome.
Maja Kiselinova +2 more
doaj +1 more source
Cellular Reservoirs of HIV-1 and their Role in Viral Persistence [PDF]
Current HIV Research, 2008 A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the
Aikaterini, Alexaki +2 more
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Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
Scientific Reports, 2021 HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed ...
Amina Ait-Ammar +12 more
doaj +1 more source
Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]
, 2009 The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
core +1 more source
Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]
, 2013 HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
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