Current approaches to assess HIV-1 persistence. [PDF]
Current Opinion in HIV and AIDS, 2016 The persistence of HIV within long-lived HIV-infected CD4 T cells is the primary obstacle towards HIV eradication and numerous strategies are currently being evaluated to target and kill HIV-infected cells to ultimately find a cure.
Procopio, F.A., Perreau, M., Banga, R.
core +4 more sources
Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence [PDF]
Contemporary Clinical Trials Communications, 2021 Background: Opioid use disorder (OUD) negatively impacts the HIV continuum of care for persons living with HIV (PLH). Medication treatment for OUD (MOUD) may have differential biological effects in individuals with HIV and OUD.
Alysse Schultheis +6 more
doaj +2 more sources
The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells [PDF]
The Journal of Clinical Investigation, 2022 Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted.
Gabriel Duette +22 more
doaj +2 more sources
Sex differences in HIV-1 persistence and the implications for a cure. [PDF]
Front Glob Womens Health, 2022 Of the 38 million people currently living with Human Immunodeficiency Virus type-1 (HIV-1), women, especially adolescents and young women, are disproportionally affected by the HIV-1 pandemic. Acquired immunodeficiency syndrome (AIDS) - related illnesses are the leading cause of death in women of reproductive age worldwide.
Rao S.
europepmc +4 more sources
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence [PDF]
Immunity, 2023 Ann Duerr, Jack Collora, Ya-Chi Ho
exaly +2 more sources
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage [PDF]
Retrovirology, 2010 The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage
Rohr Olivier +3 more
doaj +5 more sources
Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence [PDF]
Nature CommunicationsInitiation of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) has been proposed to limit the formation of HIV-1 reservoirs. However, it remains unknown whether temporary ART initiated during PHI has a long-term effect on viral ...
Alexander O. Pasternak +11 more
doaj +3 more sources
Persistent HIV-1 Viremia on Antiretroviral Therapy: Measurement and Mechanisms [PDF]
Frontiers in Microbiology, 2019 HIV-1 viremia persists at low-levels despite clinically effective antiretroviral therapy (ART). Here we review new methods to quantify and characterize persistent viremia at the single genome level, and discuss the mechanisms of persistence including ...
Jana L. Jacobs +3 more
doaj +3 more sources
Hiding in plain sight – platelets, the silent carriers of HIV-1
Platelets, 2021 There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer +11 more
doaj +1 more source
Latency and viral persistence in HIV-1 infection [PDF]
Journal of Clinical Investigation, 2000 HIV-1 infection can be controlled with combinations of antiretroviral drugs, an approach known as highly active antiretroviral therapy (HAART). In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins.
J D, Siliciano, R F, Siliciano
openaire +2 more sources