The Interplay of HIV-1 and Macrophages in Viral Persistence [PDF]
Frontiers in Microbiology, 2021 HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the powerful effects of highly active antiretroviral therapies (HAART ...
Chynna M. Hendricks +3 more
doaj +5 more sources
Episomal HIV-1 DNA and its relationship to other markers of HIV-1 persistence [PDF]
Retrovirology, 2018 Reverse transcription of HIV-1 results in the generation of a linear cDNA that serves as the precursor to the integrated provirus. Other classes of extrachromosomal viral cDNA molecules can be found in acutely infected cells including the 1-LTR and 2-LTR
Javier Martinez-Picado +3 more
doaj +6 more sources
Current approaches to assess HIV-1 persistence.
Current Opinion in HIV and AIDS, 2016 The persistence of HIV within long-lived HIV-infected CD4 T cells is the primary obstacle towards HIV eradication and numerous strategies are currently being evaluated to target and kill HIV-infected cells to ultimately find a cure.
Procopio, F.A., Perreau, M., Banga, R.
core +4 more sources
Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence [PDF]
Viruses, 2020 While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts +4 more
doaj +3 more sources
Sex differences in HIV-1 persistence and the implications for a cure. [PDF]
Front Glob Womens Health, 2022 Of the 38 million people currently living with Human Immunodeficiency Virus type-1 (HIV-1), women, especially adolescents and young women, are disproportionally affected by the HIV-1 pandemic. Acquired immunodeficiency syndrome (AIDS) - related illnesses are the leading cause of death in women of reproductive age worldwide.
Rao S.
europepmc +4 more sources
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage [PDF]
Retrovirology, 2010 The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage
Rohr Olivier +3 more
doaj +5 more sources
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence [PDF]
Immunity, 2023 Ann C Duerr, Jack A Collora, Ya-Chi Ho
exaly +2 more sources
Persistent HIV-1 Viremia on Antiretroviral Therapy: Measurement and Mechanisms [PDF]
Frontiers in Microbiology, 2019 HIV-1 viremia persists at low-levels despite clinically effective antiretroviral therapy (ART). Here we review new methods to quantify and characterize persistent viremia at the single genome level, and discuss the mechanisms of persistence including ...
Jana L. Jacobs +3 more
doaj +3 more sources
Hiding in plain sight – platelets, the silent carriers of HIV-1
Platelets, 2021 There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer +11 more
doaj +1 more source
Characteristics, immunological response & treatment outcomes of HIV-2 compared with HIV-1 & dual infections (HIV 1/2) in Mumbai. [PDF]
, 2010 BACKGROUND AND OBJECTIVES: Information available on HIV-2 and dual infection (HIV-1/2) is limited. This study was carried out among HIV positive individuals in an urban referral clinic in Khar, Mumbai, India, to report on relative proportions of HIV-1 ...
Manzi, M +8 more
core +6 more sources