Results 1 to 10 of about 32,488 (258)

The role of Tat in HIV latency and reactivation [PDF]

Frontiers in Immunology
HIV persists during therapy due the existence of a latently infected reservoir in which viral gene expression is silenced. This reservoir thus represents the primary barrier to a cure for HIV.
David M. Margolis, Edward P. Browne
doaj   +10 more sources

β-catenin regulates HIV latency and modulates HIV reactivation. [PDF]

PLoS Pathogens, 2022
Latency is the main obstacle towards an HIV cure, with cure strategies aiming to either elicit or prevent viral reactivation. While these strategies have shown promise, they have only succeeded in modulating latency in a fraction of the latent HIV ...
Hannah J Barbian, Melanie S Seaton, Srinivas D Narasipura, Jennillee Wallace, Reshma Rajan, Beverly E Sha, Lena Al-Harthi   +6 more
doaj   +3 more sources

Diverse effects of interferon alpha on the establishment and reversal of HIV latency.

PLoS Pathogens, 2020
HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells.
Renée M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jérémy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron   +16 more
doaj   +2 more sources

Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency

Cell Reports, 2018
Summary: A detailed understanding of the mechanisms that establish or maintain the latent reservoir of HIV will guide approaches to eliminate persistent infection. We used a cell line and primary cell models of HIV latency to investigate viral RNA (vRNA)
Todd Bradley, Guido Ferrari, Barton F. Haynes, David M. Margolis, Edward P. Browne   +4 more
doaj   +3 more sources

IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation [PDF]

Frontiers in Immunology, 2022
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute ...
Ifeanyi Jude Ezeonwumelu, Edurne García-Vidal, Eudald Felip, Eudald Felip, Maria C. Puertas, Maria C. Puertas, Bruna Oriol-Tordera, Lucía Gutiérrez-Chamorro, André Gohr, Marta Ruiz-Riol, Marta Ruiz-Riol, Marta Massanella, Marta Massanella, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Roger Badia, Eva Riveira-Muñoz, Ester Ballana   +22 more
doaj   +2 more sources

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. [PDF]

PLoS Pathogens, 2015
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus (HIV) replication to undetectable levels but cannot fully eradicate the virus because a small reservoir of CD4+ T cells remains latently infected.
Leonard Chavez, Vincenzo Calvanese, Eric Verdin   +2 more
doaj   +3 more sources

Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4+ T cells: A pooled data-analysis

Frontiers in Immunology, 2022
The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making primary
Anne Inderbitzin, Anne Inderbitzin, Anne Inderbitzin, Tom Loosli, Tom Loosli, Tom Loosli, Lennart Opitz, Peter Rusert, Karin J. Metzner, Karin J. Metzner   +9 more
doaj   +1 more source

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) cannot be completely eliminated because of existence of the latent HIV-1 reservoir. However, the facts of HIV-1 latency, including its establishment and maintenance, are incomplete.
Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Yinzhong Shen, Yanan Wang, Panpan Lu, Zhengtao Jiang, Hanyu Pan, Jinlong Yang, Jingna Xun, Lin Zhao, Jing Wang, Zhiming Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Lu Jin, Dengji Zhang, Jun Liu, Bin Wang, Shibo Jiang, Jianqing Xu, Hao Wu, Hongzhou Lu, Huanzhang Zhu   +25 more
doaj   +1 more source

UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat

mBio, 2021
HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang, Qiao Zhang, Ziyao Wu, Pei Chen, Yifan Huang, Shuwen Liu, Lin Li   +6 more
doaj   +1 more source

Bridging HIV-1 cellular latency and clinical long-term non-progressor: an interactomic view. [PDF]

PLoS ONE, 2013
Development of an effective HIV management is enticed by the fact that long-term non-progressors (LTNP) restrict viral replication spontaneously, but is hindered by HIV-1 latency.
Jin Yang, Zongxing Yang, Hangjun Lv, Yi Lou, Juan Wang, Nanping Wu   +5 more
doaj   +1 more source