Results 1 to 10 of about 799,404 (198)

An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review

HIV/AIDS: Research and Palliative Care, 2023
Peter W Ramirez,1 Christina Pantoja,1 Nadejda Beliakova-Bethell2,3 1Department of Biological Sciences, California State University, Long Beach, CA, USA; 2VA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, CA, USA ...
Ramirez PW, Pantoja C, Beliakova-Bethell N   +2 more
doaj   +1 more source

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

The Journal of Clinical Investigation, 2022
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis   +30 more
doaj   +1 more source

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +1 more source

Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal.

PLoS ONE, 2019
The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency ...
Wim Trypsteen, Cory H White, Amey Mukim, Celsa A Spina, Ward De Spiegelaere, Steve Lefever, Vicente Planelles, Alberto Bosque, Christopher H Woelk, Linos Vandekerckhove, Nadejda Beliakova-Bethell   +10 more
doaj   +1 more source

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?

Viruses
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara, Yasuko Tsunetsugu-Yokota   +1 more
doaj   +1 more source

The ENL-USP7 complex regulates HIV latency through BRD4 protein stabilization

Cell Reports
Summary: HIV persistence in CD4 + T cells and brain microglia is maintained by host mechanisms that enforce viral latency. We identify ENL and the deubiquitinase USP7 as a host complex that sustains HIV latency.
Waqas Ahmed, Xiaoyi Li, Ciniso S. Shabangu, Hongjie Chen, Nikesh Katuwal, Jennifer Kirchherr, Wenshe R. Liu, Xin Li, Yongcheng Song, Kaixiu Luo, H. Umit Kaniskan, Jian Jin, Sara Gianella, David M. Margolis, Nancie M. Archin, Yuyang Tang, Guochun Jiang   +16 more
doaj   +1 more source

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Clinical Epigenetics, 2018
HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan, Mazhar Iqbal, Muhammad Tariq, Shahid M. Baig, Wasim Abbas   +4 more
doaj   +1 more source

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi   +14 more
doaj   +1 more source

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

Cell Reports, 2019
Summary: Latent proviruses persist in central (TCM), transitional (TTM), and effector (TEM) memory cells. We measured the levels of cellular factors involved in HIV gene expression in these subsets.
Marion Pardons, Rémi Fromentin, Amélie Pagliuzza, Jean-Pierre Routy, Nicolas Chomont   +4 more
doaj   +1 more source

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells

iScience
Summary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj   +1 more source