Results 1 to 10 of about 32,363 (272)
A Hardwired HIV Latency Program [PDF]
Cell, 2015 SummaryBiological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with ...
Rouzine, Igor +14 more
core +6 more sources
MicroRNA-155 Reinforces HIV Latency* [PDF]
Journal of Biological Chemistry, 2015 The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death due
Oh, Eugene +8 more
core +6 more sources
Primary Cell Models of Hiv Latency
Current Opinion in HIV and AIDS, 2012 Purpose of review: To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.
楊宏志, YANG, HUNG-CHIH
core +3 more sources
Emerging Microbes and Infections, 2022 HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen +12 more
doaj +1 more source
Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis
Cellular Physiology and Biochemistry, 2015 Background/Aims: The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis
Zongxing Yang +6 more
doaj +1 more source
HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]
, 2012 HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Eberle, Josef, Gürtler, Lutz
core +1 more source
Cell Reports, 2018 Summary: Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells.
Monica Golumbeanu +6 more
doaj +1 more source
PLoS Pathogens, 2023 Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh +6 more
doaj +1 more source
PLoS Pathogens, 2016 The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White +9 more
doaj +1 more source
Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir [PDF]
, 2016 Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-Treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-Treated patients to make latent cells visible to the ...
De Wit, S +28 more
core +1 more source