Results 41 to 50 of about 799,404 (198)

X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4⁺ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

mBio, 2020
Reversible repression of HIV-1 5′ long terminal repeat (5′-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency.
Li Ma, Qing-An Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, Jian-Hua Wang   +7 more
doaj   +1 more source

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

Communications Biology, 2023
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Mie Kobayashi-Ishihara, Katarína Frazão Smutná, Florencia E. Alonso, Jordi Argilaguet, Anna Esteve-Codina, Kerstin Geiger, Meritxell Genescà, Judith Grau-Expósito, Clara Duran-Castells, Selina Rogenmoser, René Böttcher, Jennifer Jungfleisch, Baldomero Oliva, Javier P. Martinez, Manqing Li, Michael David, Makoto Yamagishi, Marta Ruiz-Riol, Christian Brander, Yasuko Tsunetsugu-Yokota, Maria J. Buzon, Juana Díez, Andreas Meyerhans   +22 more
doaj   +1 more source

Human Immunodeficiency Virus-1 Latency Reversal via the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation

Frontiers in Microbiology, 2022
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang, Guochun Jiang   +8 more
doaj   +1 more source

HIV reservoirs and latency models

Virology, 2011
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J., Agosto, Luis, Graf, Erin H., O'Doherty, Una   +3 more
openaire   +2 more sources

Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis

Cellular Physiology and Biochemistry, 2015
Background/Aims: The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis
Zongxing Yang, Jin Yang, Juan Wang, Xiangyun Lu, Changzhong Jin, Tiansheng Xie, Nanping Wu   +6 more
doaj   +1 more source

Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes [PDF]

, 2012
BACKGROUND: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups.
Thomas Bodmer, Gagneux, Sebastien, Bodmer, Thomas, Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups, Schrenzel, J., Bottger, E. C., Schrenzel Jacques, Jean-Paul Janssens (174301), Cavassini Matthias, Matthias Egger, Enos Bernasconi (174329), Jacques Schrenzel, Egger, M., Böttger Erik C., Schrenzel, Jacques, Matthias Egger (24558), Böttger, E.C., Jan Fehr (174310), Fehr Jan, Janssens, J. P., Bodmer Thomas, Bernasconi, E., Gagneux, S., Fenner, Lukas, Egger, Matthias, Enos Bernasconi, Egger Matthias, Hoffmann, Matthias, Erik C. Böttger (174343), Cavassini, M., Matthias Hoffmann, Jacques Schrenzel (22586), Janssens, J.P., Böttger, Erik C, Helbling, Peter, Matthias Cavassini (146654), Gagneux Sebastien, Fenner, L., Matthias Hoffmann (174320), Peter Helbling (174346), Helbling, P., Bernasconi, Enos, Jan Fehr, Erik C Böttger, Thomas Bodmer (174337), Lukas Fenner, Fenner Lukas, Fehr, Jan, for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculo,, Janssens, Jean-Paul, Helbling Peter, Bernasconi Enos, Sebastien Gagneux (149824), Janssens Jean-Paul, Hoffmann, M., Hoffmann Matthias, Sebastien Gagneux, Peter Helbling, Lukas Fenner (149822), Jean-Paul Janssens, Fehr, J., Cavassini, Matthias, Bodmer, T., Matthias Cavassini   +63 more
core   +3 more sources

Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells

Cell Reports, 2018
Summary: Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells.
Monica Golumbeanu, Sara Cristinelli, Sylvie Rato, Miguel Munoz, Matthias Cavassini, Niko Beerenwinkel, Angela Ciuffi   +6 more
doaj   +1 more source

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Emerging Microbes and Infections, 2022
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang   +12 more
doaj   +1 more source

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.

PLoS Pathogens, 2023
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman   +6 more
doaj   +1 more source

IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation

Frontiers in Immunology, 2022
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute ...
Ifeanyi Jude Ezeonwumelu, Edurne García-Vidal, Eudald Felip, Eudald Felip, Maria C. Puertas, Maria C. Puertas, Bruna Oriol-Tordera, Lucía Gutiérrez-Chamorro, André Gohr, Marta Ruiz-Riol, Marta Ruiz-Riol, Marta Massanella, Marta Massanella, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Javier Martinez-Picado, Roger Badia, Eva Riveira-Muñoz, Ester Ballana   +22 more
doaj   +1 more source