Results 41 to 50 of about 32,488 (258)

Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro. [PDF]

PLoS ONE, 2016
Developing robust in vitro models of HIV latency is needed to better understand how latency is established, maintained and reversed. In this study, we examined the effects of donor variability, HIV titre and co-receptor usage on establishing HIV latency ...
Jenny L Anderson, Talia M Mota, Vanessa A Evans, Nitasha Kumar, Simin D Rezaei, Karey Cheong, Ajantha Solomon, Fiona Wightman, Paul U Cameron, Sharon R Lewin   +9 more
doaj   +1 more source

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products [PDF]

, 2018
Natural products originating from marine and plant materials are a rich source of chemical diversity and unique antimicrobials. Using an established in vitro model of HIV-1 latency, we screened 257 pure compounds from a marine natural product library and
Andersen, Raymond J., E. Dilip de Silva, David E. Williams, Tietjen, Ian, Brumme, Zabrina L., Mark A. Brockman, Raymond J. Andersen, Zabrina L. Brumme, E. Dilip De Silva, Zabrina L. Brumme, Brockman, Mark A., David E. Williams, Ian Tietjen, Mark A. Brockman, Richard, Khumoekae, Khumoekae Richard, Raymond J. Andersen, Williams, David E., De Silva, E. Dilip   +18 more
core   +1 more source

X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4⁺ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

mBio, 2020
Reversible repression of HIV-1 5′ long terminal repeat (5′-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency.
Li Ma, Qing-An Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, Jian-Hua Wang   +7 more
doaj   +1 more source

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

Communications Biology, 2023
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Mie Kobayashi-Ishihara, Katarína Frazão Smutná, Florencia E. Alonso, Jordi Argilaguet, Anna Esteve-Codina, Kerstin Geiger, Meritxell Genescà, Judith Grau-Expósito, Clara Duran-Castells, Selina Rogenmoser, René Böttcher, Jennifer Jungfleisch, Baldomero Oliva, Javier P. Martinez, Manqing Li, Michael David, Makoto Yamagishi, Marta Ruiz-Riol, Christian Brander, Yasuko Tsunetsugu-Yokota, Maria J. Buzon, Juana Díez, Andreas Meyerhans   +22 more
doaj   +1 more source

Human Immunodeficiency Virus-1 Latency Reversal via the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation

Frontiers in Microbiology, 2022
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang, Guochun Jiang   +8 more
doaj   +1 more source

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Emerging Microbes and Infections, 2022
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang   +12 more
doaj   +1 more source

Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation [PDF]

Proceedings of the National Academy of Sciences of the United States of America
Collin Kieffer, Roy Dar, Alexandra Blanco   +2 more
exaly   +2 more sources

Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis

Cellular Physiology and Biochemistry, 2015
Background/Aims: The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis
Zongxing Yang, Jin Yang, Juan Wang, Xiangyun Lu, Changzhong Jin, Tiansheng Xie, Nanping Wu   +6 more
doaj   +1 more source

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.

PLoS Pathogens, 2023
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman   +6 more
doaj   +1 more source

HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]

, 2012
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Eberle, Josef, Gürtler, Lutz
core   +1 more source