Results 51 to 60 of about 32,363 (272)

X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4⁺ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

mBio, 2020
Reversible repression of HIV-1 5′ long terminal repeat (5′-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency.
Li Ma, Qing-An Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, Jian-Hua Wang   +7 more
doaj   +1 more source

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

Communications Biology, 2023
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Mie Kobayashi-Ishihara, Katarína Frazão Smutná, Florencia E. Alonso, Jordi Argilaguet, Anna Esteve-Codina, Kerstin Geiger, Meritxell Genescà, Judith Grau-Expósito, Clara Duran-Castells, Selina Rogenmoser, René Böttcher, Jennifer Jungfleisch, Baldomero Oliva, Javier P. Martinez, Manqing Li, Michael David, Makoto Yamagishi, Marta Ruiz-Riol, Christian Brander, Yasuko Tsunetsugu-Yokota, Maria J. Buzon, Juana Díez, Andreas Meyerhans   +22 more
doaj   +1 more source

Human Immunodeficiency Virus-1 Latency Reversal via the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation

Frontiers in Microbiology, 2022
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang, Guochun Jiang   +8 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation [PDF]

Proceedings of the National Academy of Sciences of the United States of America
Alexandra Blanco, Neha Arun, Roy D Dar
exaly   +2 more sources

Insights into the HIV Latency and the Role of Cytokines [PDF]

Pathogens, 2019
Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual CD4+ cells. Latent HIV-1 proviruses are transcriptionally silent and immunologically inert, but are still capable of reactivating productive lytic infection following cellular activation.
Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Manjari Dimri, Mudit Tyagi   +3 more
openaire   +3 more sources

Chromatin, gene silencing and HIV latency [PDF]

Genome Biology, 2007
One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral ...
Mok, Hoi-Ping, Lever, Andrew ML
openaire   +2 more sources

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.

PLoS Pathogens, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai   +17 more
doaj   +1 more source

Ephedrine enhances HIV-1 reactivation from latency through elevating tumor necrosis factor receptor II (TNFRII) expression

Heliyon, 2019
HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The latently-infected cells, or reservoir cells, are transcriptionally absent and invisible to
Jutatip Panaampon, Eriko Kudo, Ryusho Kariya, Seiji Okada   +3 more
doaj   +1 more source

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. [PDF]

, 2022
The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1.
Pasternak, Alexander, Passaes, Caroline Pereira Bittencourt, Cicilionyte, Aurelija, Le Douce, Valentin, Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Berkhout, Ben, Delacourt, Nadège, Pasternak, Alexander O., Verdikt, Roxane, Plant, Estelle, Vanhulle, Caroline, Avettand-Fenoel, V. ronique, Pasternak, Alexander O, Gautier, Virginie, Bendoumou, Maryam, Santangelo, Marion, Schwartz, Christian, Rohr, Olivier, Rouzioux, Christine, Nestola, Lorena, Sáez-Cirión, Asier, Avettand-Fenoel, Veronique, Ait-Ammar, Amina, Douce, Valentin Le, Necsoi, Coca, Bouchat, Sophie, Corazza, Francis, Bizet, Martin, Fuks, François   +30 more
core   +1 more source