Results 51 to 60 of about 799,404 (198)
PLoS Pathogens, 2016 The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White +9 more
doaj +1 more source
Concurrent sexual partnerships and HIV prevalence in five urban communities of sub-Saharan Africa. [PDF]
, 2001 OBJECTIVE: To estimate parameters of concurrent sexual partnerships in five urban populations in sub-Saharan Africa and to assess their association with levels of HIV infection and other sexually transmitted infections (STI).
Lagarde, E. +24 more
core +1 more source
The BAF complex and HIV latency [PDF]
Transcription, 2012 The persistence of a reservoir of transcriptionally competent but latent virus in the presence of antiviral regimens presents the main impediment to a curative therapy against HIV. Therefore it is critical to understand the molecular mechanisms, which lead to the establishment and maintenance of HIV latency, and which contribute to the reversal of this
openaire +3 more sources
Insights into the HIV Latency and the Role of Cytokines [PDF]
Pathogens, 2019 Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual CD4+ cells. Latent HIV-1 proviruses are transcriptionally silent and immunologically inert, but are still capable of reactivating productive lytic infection following cellular activation.
Joseph Hokello +3 more
openaire +3 more sources
PANGEA-HIV/PANGEA-Sequences: v1.0.0
, 2023 <h2><a href="https://github.com/pangea-hiv/#hiv-consensus-sequence-repository-of-the-pangea-hiv-consortium">HIV Consensus Sequence Repository</a><br><a href="https://github.com/pangea-hiv/#hiv-consensus-sequence-repository-of ...
PANGEA-HIV Consortium
core +1 more source
Chromatin, gene silencing and HIV latency [PDF]
Genome Biology, 2007 One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral ...
Mok, Hoi-Ping, Lever, Andrew ML
openaire +2 more sources
Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaCollin Kieffer +2 more
exaly +2 more sources
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
PLoS Pathogens, 2016 Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen +17 more
doaj +1 more source
Molecular Understanding of HIV-1 Latency [PDF]
Advances in Virology, 2012 The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough in the treatment of HIV-1 infection and has also a powerful tool to upset the equilibrium of viral production and HIV-1 pathogenesis. Despite the advent of potent combinations of this therapy, the long-lived HIV-1 reservoirs like cells from monocyte ...
W. Abbas, G. Herbein
openaire +3 more sources
Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]
, 2007 Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Michael Simpson +2 more
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