Results 51 to 60 of about 32,488 (258)

Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells

Cell Reports, 2018
Summary: Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells.
Monica Golumbeanu, Sara Cristinelli, Sylvie Rato, Miguel Munoz, Matthias Cavassini, Niko Beerenwinkel, Angela Ciuffi   +6 more
doaj   +1 more source

Combination immune checkpoint blockade to reverse HIV latency [PDF]

, 2020
In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4+ T cells expressing multiple immune checkpoint (IC) molecules, including programmed death (PD)-1, T cell Ig and mucin ...
Sékaly, RP, Pascoe, RD, Evans, VA, Zerbato, JM, Chomont, N, Kumar, NA, Van Der Sluis, RM, Anderson, JL, Lewin, SR, Dantanarayana, AI, Fromentin, R, Cameron, PU   +11 more
core   +1 more source

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.

PLoS Pathogens, 2016
The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White, Bastiaan Moesker, Nadejda Beliakova-Bethell, Laura J Martins, Celsa A Spina, David M Margolis, Douglas D Richman, Vicente Planelles, Alberto Bosque, Christopher H Woelk   +9 more
doaj   +1 more source

Insights into the HIV Latency and the Role of Cytokines [PDF]

Pathogens, 2019
Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual CD4+ cells. Latent HIV-1 proviruses are transcriptionally silent and immunologically inert, but are still capable of reactivating productive lytic infection following cellular activation.
Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Manjari Dimri, Mudit Tyagi   +3 more
openaire   +3 more sources

HIV-1 transcription and latency: an update [PDF]

Retrovirology, 2013
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a rapid rebound of viremia. Reactivation of latently infected cells harboring transcriptionally silent but replication-competent proviruses is a potential source of ...
Van Lint, Carine, Bouchat, Sophie, Marcello, Alexandro   +2 more
openaire   +3 more sources

Exploring HIV latency using transcription profiling [PDF]

, 2017
The major barrier to a cure for HIV is the existence of reservoirs consisting predominantly of latently infected CD4+ T cells, which do not produce virus constitutively but can be induced to produce infectious virus on activation.
Sushama Telwatte, Steven A Yukl
core   +1 more source

Chromatin, gene silencing and HIV latency [PDF]

Genome Biology, 2007
One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral ...
Mok, Hoi-Ping, Lever, Andrew ML
openaire   +2 more sources

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir [PDF]

, 2016
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-Treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-Treated patients to make latent cells visible to the ...
De Wit, S, Rohr, O, Rohr, O. (Olivier), Van Lint, C. (Carine), De Wit, S. (Stéphane), Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Rouzioux, C, Vanhulle, C. (Caroline), Bouchat, S, Kula, Anna, Delacourt, Nadège, Bouchat, S. (Sophie), Vanhulle, Caroline, Delacourt, N, Rouzioux, C. (Christine), Darcis, G. (Gilles), Rohr, Olivier, Rouzioux, Christine, Van Driessche, Benoît, Avettand-Fenoel, Veronique, Vanhulle, C, Avettand-Fenoel, V. (Véronique), Van Driessche, B, Delacourt, N. (Nadège), Bouchat, Sophie, Van Driessche, B. (Benoit), Kula, A. (Anna)   +28 more
core   +1 more source

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.

PLoS Pathogens, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai   +17 more
doaj   +1 more source

Ephedrine enhances HIV-1 reactivation from latency through elevating tumor necrosis factor receptor II (TNFRII) expression

Heliyon, 2019
HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The latently-infected cells, or reservoir cells, are transcriptionally absent and invisible to
Jutatip Panaampon, Eriko Kudo, Ryusho Kariya, Seiji Okada   +3 more
doaj   +1 more source