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HIV-1 Latency by Transition [PDF]

Immunity, 2017
The latent HIV-1 reservoir represents the major barrier for the development of an HIV-1 cure. In this issue of Immunity, Shan et al. (2017) highlight that effector-to-memory transitioning (EMT) CD4+ T cells are particularly permissive for the establishment of latent HIV-1 infection.
Boris, Julg, Dan H, Barouch
openaire   +2 more sources

Molecular mechanisms of HIV latency [PDF]

Journal of Clinical Investigation, 2016
HIV seeds reservoirs of latent proviruses in the earliest phases of infection. These reservoirs are found in many sites, including circulating cells, the lymphoid system, the brain, and other tissues. The "shock and kill" strategy, where HIV transcription is reactivated so that antiretroviral therapy and the immune system clear the infection, has been ...
Daniele C, Cary, Koh, Fujinaga, B Matija, Peterlin   +2 more
openaire   +2 more sources

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

Journal of Virus Eradication, 2023
A better understanding of HIV-1 latency is a research priority in HIV cure research. Conversely, little is known about the latency characteristics of HIV-2, the closely related human lentivirus.
Anne Bruggemans, Gerlinde Vansant, Paulien Van de Velde, Zeger Debyser   +3 more
doaj   +1 more source

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

EBioMedicine, 2016
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko, Elisa De Crignis, Casper Rokx, Mir Mubashir Khalid, Cynthia Lungu, Robert-Jan Palstra, Tsung Wai Kan, Charles Boucher, Annelies Verbon, Emily C. Dykhuizen, Tokameh Mahmoudi   +10 more
doaj   +1 more source

Understanding HIV Latency: The Road to an HIV Cure [PDF]

Annual Review of Medicine, 2015
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected individuals. However, treatment has to be continued for life because it does not lead to the full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell types, and can reemerge from these cells when therapy is interrupted.
Matthew S, Dahabieh, Emilie, Battivelli, Eric, Verdin   +2 more
openaire   +2 more sources

Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro. [PDF]

PLoS ONE, 2016
Developing robust in vitro models of HIV latency is needed to better understand how latency is established, maintained and reversed. In this study, we examined the effects of donor variability, HIV titre and co-receptor usage on establishing HIV latency ...
Jenny L Anderson, Talia M Mota, Vanessa A Evans, Nitasha Kumar, Simin D Rezaei, Karey Cheong, Ajantha Solomon, Fiona Wightman, Paul U Cameron, Sharon R Lewin   +9 more
doaj   +1 more source

Selective miRNA Modulation Fails to Activate HIV Replication in In Vitro Latency Models

Molecular Therapy: Nucleic Acids, 2019
HIV remains incurable because of viral persistence in latent reservoirs that are inaccessible to antiretroviral therapy. A potential curative strategy is to reactivate viral gene expression in latently infected cells.
María Rosa López-Huertas, Matías Morín, Nadia Madrid-Elena, Carolina Gutiérrez, Laura Jiménez-Tormo, Javier Santoyo, Francisco Sanz-Rodríguez, Miguel Ángel Moreno Pelayo, Laura García Bermejo, Santiago Moreno   +9 more
doaj   +1 more source

MicroRNA-155 Reinforces HIV Latency [PDF]

Journal of Biological Chemistry, 2015
The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death due to a viral cytopathic effect, 2) cell death due to immune clearance, or 3) a retreat into latency ...
Ruelas, Debbie S, Chan, Jonathan K, Oh, Eugene, Heidersbach, Amy J, Hebbeler, Andrew M, Chavez, Leonard, Verdin, Eric, Rape, Michael, Greene, Warner C   +8 more
openaire   +4 more sources

Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression [PDF]

, 2010
Background: Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by
Scheuring Urban J, Oliver G Ottmann, Dietrich, Ursula, Capalbo Gianni, Scheuring, Urban J., Ursula Dietrich, Ottmann, Oliver G., Dietrich Ursula, Gianni Capalbo, Urban J Scheuring, Hoelzer, Dieter (Prof. Dr.), Müller-Kuller Thea, Hoelzer Dieter, Ottmann Oliver G, Dieter Hoelzer, Thea Müller-Kuller, Capalbo, Gianni, Müller-Kuller, Thea   +17 more
core   +1 more source

Korespondensi Jurnal HIV Nursing: Bibliometric analysis on policy strategies regarding HIV/AIDS [PDF]

, 2023
The Covid-19 pandemic that has hit the world of health in the last 2-3 years has been given more significant impact on people living with HIV/AIDS globally.
Umam, Khaerul
core   +1 more source