Results 31 to 40 of about 32,363 (272)

HIV Latency in the Humanized BLT Mouse [PDF]

Journal of Virology, 2012
Even after extended treatment with powerful antiretroviral drugs, HIV is not completely eliminated from infected individuals. Latently infected CD4 + T cells constitute one reservoir of replication-competent HIV that needs to be ...
Matthew D. Marsden, Michael Kovochich, Saki Shimizu, Gregory Bristol, Nuttee Suree, Roshni Mehta, Dong Sung An, Ruth Cortado, Jerome A. Zack   +8 more
core   +3 more sources

The multifaceted nature of HIV latency. [PDF]

J Clin Invest, 2021
Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during ART. A large number of studies conducted during the past 20 years have shown that HIV persists in a small pool of cells harboring integrated and replication ...
Dufour C, Gantner P, Fromentin R, Chomont N.   +3 more
europepmc   +6 more sources

Bioinformatics and HIV Latency [PDF]

Current HIV/AIDS Reports, 2015
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan.
Ciuffi, Angela, Mohammadi, Pejman, Golumbeanu, Monica, Telenti, Amalio, di Iulio, Julia   +4 more
openaire   +8 more sources

Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4+ T cells: A pooled data-analysis

Frontiers in Immunology, 2022
The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making primary
Anne Inderbitzin, Anne Inderbitzin, Anne Inderbitzin, Tom Loosli, Tom Loosli, Tom Loosli, Lennart Opitz, Peter Rusert, Karin J. Metzner, Karin J. Metzner   +9 more
doaj   +1 more source

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) cannot be completely eliminated because of existence of the latent HIV-1 reservoir. However, the facts of HIV-1 latency, including its establishment and maintenance, are incomplete.
Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Yinzhong Shen, Yanan Wang, Panpan Lu, Zhengtao Jiang, Hanyu Pan, Jinlong Yang, Jingna Xun, Lin Zhao, Jing Wang, Zhiming Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Lu Jin, Dengji Zhang, Jun Liu, Bin Wang, Shibo Jiang, Jianqing Xu, Hao Wu, Hongzhou Lu, Huanzhang Zhu   +25 more
doaj   +1 more source

HIV Latency [PDF]

Cold Spring Harbor Perspectives in Medicine, 2011
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression.
Robert F, Siliciano, Warner C, Greene
openaire   +2 more sources

UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat

mBio, 2021
HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang, Qiao Zhang, Ziyao Wu, Pei Chen, Yifan Huang, Shuwen Liu, Lin Li   +6 more
doaj   +1 more source

Bridging HIV-1 cellular latency and clinical long-term non-progressor: an interactomic view. [PDF]

PLoS ONE, 2013
Development of an effective HIV management is enticed by the fact that long-term non-progressors (LTNP) restrict viral replication spontaneously, but is hindered by HIV-1 latency.
Jin Yang, Zongxing Yang, Hangjun Lv, Yi Lou, Juan Wang, Nanping Wu   +5 more
doaj   +1 more source

A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency

Viruses, 2023
We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer, Abby Felton, Yennifer Delgado, Harini Srinivasan, Michael Emerman   +4 more
doaj   +1 more source

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

mBio, 2021
To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi   +13 more
doaj   +1 more source