Results 21 to 30 of about 32,488 (258)
Identification of unrecognized host factors promoting HIV-1 latency. [PDF]
PLoS Pathogens, 2020 To counter HIV latency, it is important to develop a better understanding of the full range of host factors promoting latency. Their identification could suggest new strategies to reactivate latent proviruses and subsequently kill the host cells ("shock ...
Zichong Li +2 more
doaj +3 more sources
Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy? [PDF]
VirusesHuman Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara +1 more
doaj +2 more sources
Molecular Control of HIV and SIV Latency [PDF]
, 2017 The HIV latent reservoirs are considered as the main hurdle to viral eradication. Numerous mechanisms lead to the establishment of HIV latency and act at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients,
DARCIS, Gilles +4 more
openaire +4 more sources
Waking Up the Sleepers: HIV Latency and Reactivation [PDF]
Journal of the Formosan Medical Association, 2008 In a patient infected with HIV-1, the presence of latently infected cells from which the virus can be reactivated and rekindle HIV infection in the patient necessitates lifelong administration of antiretroviral treatment.
Hoi Ping Mok, Andrew Lever
doaj +2 more sources
The multifaceted nature of HIV latency. [PDF]
J Clin Invest, 2021 Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during ART. A large number of studies conducted during the past 20 years have shown that HIV persists in a small pool of cells harboring integrated and replication ...
Dufour C +3 more
europepmc +6 more sources
Bioinformatics and HIV Latency [PDF]
Current HIV/AIDS Reports, 2015 Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan.
Ciuffi, Angela +4 more
openaire +8 more sources
Cold Spring Harbor Perspectives in Medicine, 2011 HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression.
Robert F, Siliciano, Warner C, Greene
openaire +2 more sources
Viruses, 2023 We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer +4 more
doaj +1 more source
A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
doaj +1 more source
Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System [PDF]
, 2021 The central nervous system (CNS) is highly compartmentalized and serves as a specific site of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular populations that are infected by HIV or that harbor latent HIV ...
Hokello, Joseph +9 more
core +2 more sources