Results 21 to 30 of about 32,363 (272)

An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review

HIV/AIDS: Research and Palliative Care, 2023
Peter W Ramirez,1 Christina Pantoja,1 Nadejda Beliakova-Bethell2,3 1Department of Biological Sciences, California State University, Long Beach, CA, USA; 2VA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, CA, USA ...
Ramirez PW, Pantoja C, Beliakova-Bethell N   +2 more
doaj   +1 more source

Identification of unrecognized host factors promoting HIV-1 latency. [PDF]

PLoS Pathogens, 2020
To counter HIV latency, it is important to develop a better understanding of the full range of host factors promoting latency. Their identification could suggest new strategies to reactivate latent proviruses and subsequently kill the host cells ("shock ...
Zichong Li, Cyrus Hajian, Warner C Greene   +2 more
doaj   +2 more sources

Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies. [PDF]

NPJ Syst Biol Appl
Combination antiretroviral therapy controls human immunodeficiency virus-1 (HIV) but cannot eradicate latent proviruses in immune cells, which reactivate upon treatment interruption.
Rasi G, Emili E, Conway JM, Cotugno N, Palma P.   +4 more
europepmc   +2 more sources

HIV reservoirs and latency models

Virology, 2011
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently ...
Agosto, Luis, Luis Agosto, Graf, Erin H., Erin H. Graf, Matthew J. Pace, O'Doherty, Una, Pace, Matthew J., Una O'Doherty   +7 more
core   +3 more sources

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. [PDF]

PLoS Pathogens, 2015
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus (HIV) replication to undetectable levels but cannot fully eradicate the virus because a small reservoir of CD4+ T cells remains latently infected.
Leonard Chavez, Vincenzo Calvanese, Eric Verdin   +2 more
doaj   +3 more sources

Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency [PDF]

Medecine sciences : M/S, 2010
peer reviewedThe introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1.
Olivier Rohr, Schwartz, C. (Christian), Rohr, O. (Olivier), Laetitia Redel, Le Douce, Valentin, Aunis, D. (Dominique), Valentin Le Douce, Redel, L. (Lætitia), Cherrier, T. (Thomas), Thomas Cherrier, Redel, L. (Laetitia), Christian Schwartz, Marban, C. (Céline), Schwartz, Christian, Redel, Laetitia, Rohr, Olivier, Cherrier, Thomas, Marban, Celine, Aunis, Dominique, Dominique Aunis, Marban-doran, C. (Celine), Redel, Lætitia, Céline Marban, Lætitia Redel, Marban-Doran, Celine, Le Douce, V. (Valentin)   +25 more
core   +3 more sources

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?

Viruses
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara, Yasuko Tsunetsugu-Yokota   +1 more
doaj   +2 more sources

The Cultured TCM Model of HIV Latency

, 2022
Models to study HIV latency have improved our understanding of the mechanisms involved in this process and have helped in the discovery and development of therapeutic strategies to eradicate HIV.
Alberto Bosque, Bosque, Alberto
core   +3 more sources

Waking Up the Sleepers: HIV Latency and Reactivation

Journal of the Formosan Medical Association, 2008
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can be reactivated and rekindle HIV infection in the patient necessitates lifelong administration of antiretroviral treatment.
Hoi Ping Mok, Andrew Lever
doaj   +2 more sources

Molecular Control of HIV and SIV Latency.

, 2017
peer reviewedThe HIV latent reservoirs are considered as the main hurdle to viral eradication. Numerous mechanisms lead to the establishment of HIV latency and act at the transcriptional and post-transcriptional levels.
Kirchhoff, Frank, Carine Van Lint, DARCIS, Gilles, Sophie Bouchat, Benoit Van Driessche, Gilles Darcis, Van Lint, Carine, Frank Kirchhoff, Bouchat, Sophie, Van Driessche, Benoit   +9 more
core   +4 more sources