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HIV-1 Latency in Monocytes/Macrophages [PDF]
Viruses, 2014 Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been ...
Amit Kumar, Wasim Abbas, Georges Herbein
doaj +7 more sources
Latency: the hidden HIV-1 challenge [PDF]
Retrovirology, 2006 Eradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection ...
Marcello Alessandro
doaj +5 more sources
Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy? [PDF]
VirusesHuman Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara +1 more
doaj +4 more sources
Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 info:eu-repo/semantics ...
Alexander O. Pasternak +4 more
doaj +7 more sources
[Viral latency of HIV-1]. [PDF]
Virologie (Montrouge, France), 2019 info:eu-repo/semantics ...
Bouchat, Sophie, Van Lint, Carine
openaire +4 more sources
[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency]. [PDF]
Medecine sciences : M/S, 2010 L’introduction de la multithérapie active en 1996 s’est avérée très efficace et avait entretenu l’espoir d’éradiquer le virus du Sida. Malheureusement, des obstacles à son éradication sont rapidement apparus, notamment la mise en évidence du phénomène de latence virale dans les principales cellules cibles du virus, dont les lymphocytes T CD4+ et les ...
Schwartz, Christian +6 more
openaire +4 more sources
Molecular Understanding of HIV-1 Latency [PDF]
Advances in Virology, 2012 The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough in the treatment of HIV-1 infection and has also a powerful tool to upset the equilibrium of viral production and HIV-1 pathogenesis.
W. Abbas, G. Herbein
doaj +4 more sources
Modulation of IRF7-driven transcription as a strategy to control HIV-1 latency [PDF]
Frontiers in ImmunologyBackgroundThe persistence of latent HIV-1 reservoirs remains a major barrier to achieving a cure for HIV. While latency-reversing agents (LRAs) have been extensively studied, latency-promoting agents (LPAs) offer a complementary strategy to silence viral
Ifeanyi Jude Ezeonwumelu +19 more
doaj +2 more sources
A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency [PDF]
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
doaj +3 more sources
A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. [PDF]
PLoS Pathogens, 2023 Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh +6 more
doaj +2 more sources