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Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency [PDF]

Medecine sciences : M/S, 2010
peer reviewedThe introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1.
Olivier Rohr, Schwartz, C. (Christian), Rohr, O. (Olivier), Laetitia Redel, Le Douce, Valentin, Aunis, D. (Dominique), Valentin Le Douce, Redel, L. (Lætitia), Cherrier, T. (Thomas), Thomas Cherrier, Redel, L. (Laetitia), Christian Schwartz, Marban, C. (Céline), Schwartz, Christian, Redel, Laetitia, Rohr, Olivier, Cherrier, Thomas, Marban, Celine, Aunis, Dominique, Dominique Aunis, Marban-doran, C. (Celine), Redel, Lætitia, Céline Marban, Lætitia Redel, Marban-Doran, Celine, Le Douce, V. (Valentin)   +25 more
core   +5 more sources

[Viral latency of HIV-1] [PDF]

Virologie (Montrouge, France), 2019
Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs.
Van Lint, Carine, Bouchat, Sophie
core   +3 more sources

Shocking HIV-1 with immunomodulatory latency reversing agents. [PDF]

Seminars in Immunology, 2021
The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to ...
Kula-Pacurar, Anna, Van Lint, Carine, Rodari, Anthony, Darcis, Gilles   +3 more
core   +6 more sources

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Emerging Microbes and Infections, 2022
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang   +12 more
doaj   +1 more source

Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis

Cellular Physiology and Biochemistry, 2015
Background/Aims: The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis
Zongxing Yang, Jin Yang, Juan Wang, Xiangyun Lu, Changzhong Jin, Tiansheng Xie, Nanping Wu   +6 more
doaj   +1 more source

HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]

, 2012
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Eberle, Josef, Gürtler, Lutz
core   +1 more source

HIV-1 latency in actively dividing human T cell lines [PDF]

, 2008
Background Eradication of HIV-1 from an infected individual cannot be achieved by current drug regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy and are able to replenish systemic infection ...
Berkhout Ben, Westerhout Ellen M, van Gerven, Marja L., Ben Berkhout, Rienk E Jeeninga, Westerhout, Ellen M., Jeeninga Rienk E, Jeeninga, Rienk E., Berkhout, Ben, van Gerven Marja L, Ellen M Westerhout, Marja L van Gerven   +11 more
core   +1 more source

Primary Cell Models of Hiv Latency

, 2012
Purpose of review: To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.
楊宏志, YANG, HUNG-CHIH
core   +1 more source

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir [PDF]

, 2016
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-Treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-Treated patients to make latent cells visible to the ...
De Wit, S, Rohr, O, Rohr, O. (Olivier), Van Lint, C. (Carine), De Wit, S. (Stéphane), Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Rouzioux, C, Vanhulle, C. (Caroline), Bouchat, S, Kula, Anna, Delacourt, Nadège, Bouchat, S. (Sophie), Vanhulle, Caroline, Delacourt, N, Rouzioux, C. (Christine), Darcis, G. (Gilles), Rohr, Olivier, Rouzioux, Christine, Van Driessche, Benoît, Avettand-Fenoel, Veronique, Vanhulle, C, Avettand-Fenoel, V. (Véronique), Van Driessche, B, Delacourt, N. (Nadège), Bouchat, Sophie, Van Driessche, B. (Benoit), Kula, A. (Anna)   +28 more
core   +1 more source

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.

PLoS Pathogens, 2016
The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White, Bastiaan Moesker, Nadejda Beliakova-Bethell, Laura J Martins, Celsa A Spina, David M Margolis, Douglas D Richman, Vicente Planelles, Alberto Bosque, Christopher H Woelk   +9 more
doaj   +1 more source