Results 31 to 40 of about 66,203 (260)

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3 [PDF]

Cell Communication and Signaling
Background Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, and the main obstacle is the existence of viral reservoirs. However, we currently do not fully understand the molecular mechanisms by which HIV-1 latency is established and ...
Xinyi Yang, Yuqi Zhu, Xiaying Zhao, Jingna Xun, Xingyu Wang, Yipeng Cheng, Su Xiong, Xingwen Yu, Suixiang Li, Danqing Wang, Zhiliang Hu, Yinzhong Shen, Shibo Jiang, Hongzhou Lu, Gang Wang, Huanzhang Zhu   +15 more
doaj   +2 more sources

RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

Retrovirology, 2018
Background Current antiretroviral therapy is effective in controlling HIV-1 infection. However, cessation of therapy is associated with rapid return of viremia from the viral reservoir.
Catalina Méndez, Scott Ledger, Kathy Petoumenos, Chantelle Ahlenstiel, Anthony D. Kelleher   +4 more
doaj   +3 more sources

HIV-1 latency reversal agent boosting is not limited by opioid use [PDF]

JCI Insight
Opioid use may affect the HIV-1 reservoir and its reversal from latency. We studied 47 virally suppressed people with HIV (PWH) and observed that lower concentration of HIV-1 latency reversal agents (LRAs), used with small molecules that did not reverse ...
Tyler Lilie, Jennifer Bouzy, Archana Asundi, Jessica Taylor, Samantha Roche, Alex Olson, Kendyll Coxen, Heather Corry, Hannah Jordan, Kiera Clayton, Nina Lin, Athe Tsibris   +11 more
doaj   +2 more sources

A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading? [PDF]

Viruses
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells.
Ana Luiza Abdalla, Gabriel Guajardo-Contreras, Andrew J. Mouland   +2 more
doaj   +2 more sources

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

PLoS Pathogens, 2015
UnlabelledPharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection.
Ole S Søgaard, Steffen Leth, Rikke Olesen   +2 more
exaly   +3 more sources

Roles of microRNAs in HIV-1 Replication and Latency

MicroRNA, 2016
MicroRNAs (miRNAs) are non-coding RNA molecules, with sequence length of 19-24 nucleotides, which can induce mRNA degradation and regulate protein translation repression.
Yang, Rongge, MALLARDO, MASSIMO, Sun, Binlian   +2 more
core   +4 more sources

Hypoxic microenvironment shapes HIV-1 replication and latency [PDF]

Communications Biology, 2020
: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen.
Ashcroft, Margaret, Balfe, Peter, Paes, Wayne, Rubio, Claudia Orbegozo, Yang, Hongbing, Pedroza-Pacheco, Isabela, Kliszczak, Anna E, Nawroth, Isabel, Magri, Andrea, Zhuang, Xiaodong, Borrow, Persephone, Mole, David, McKeating, Jane A   +12 more
core   +5 more sources

HIV-1 latency: From acquaintance to confidant. [PDF]

J Virus Erad
Antiretroviral therapy (ART) has transformed HIV from a fatal disease into manageable circumstance. However, the HIV reservoirs remain a main barrier to complete cure. This review emphasized when, where and how the latency is established, with focus on various host factors and viral proteins.
Yang C, Tong L, Xue J.
europepmc   +4 more sources

Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4+ T cells: A pooled data-analysis

Frontiers in Immunology, 2022
The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making primary
Anne Inderbitzin, Anne Inderbitzin, Anne Inderbitzin, Tom Loosli, Tom Loosli, Tom Loosli, Lennart Opitz, Peter Rusert, Karin J. Metzner, Karin J. Metzner   +9 more
doaj   +1 more source

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) cannot be completely eliminated because of existence of the latent HIV-1 reservoir. However, the facts of HIV-1 latency, including its establishment and maintenance, are incomplete.
Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Yinzhong Shen, Yanan Wang, Panpan Lu, Zhengtao Jiang, Hanyu Pan, Jinlong Yang, Jingna Xun, Lin Zhao, Jing Wang, Zhiming Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Lu Jin, Dengji Zhang, Jun Liu, Bin Wang, Shibo Jiang, Jianqing Xu, Hao Wu, Hongzhou Lu, Huanzhang Zhu   +25 more
doaj   +1 more source