Results 31 to 40 of about 30,551,261 (265)
mBio, 2021 HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang +6 more
doaj +1 more source
A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
doaj +1 more source
Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know
Viruses, 2020 Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is interrupted, a rapid rebound of viremia is observed.
Antoine Dutilleul +2 more
doaj +1 more source
Bridging HIV-1 cellular latency and clinical long-term non-progressor: an interactomic view. [PDF]
PLoS ONE, 2013 Development of an effective HIV management is enticed by the fact that long-term non-progressors (LTNP) restrict viral replication spontaneously, but is hindered by HIV-1 latency.
Jin Yang +5 more
doaj +1 more source
HIV-1 transcription and latency: an update [PDF]
Retrovirology, 2013 Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a rapid rebound of viremia. Reactivation of latently infected cells harboring transcriptionally silent but replication-competent proviruses is a potential source of ...
Van Lint, Carine +2 more
openaire +3 more sources
Viruses, 2023 We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer +4 more
doaj +1 more source
An Integrated Overview of HIV-1 Latency [PDF]
Cell, 2013 Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs.
Ruelas, Debbie S, Greene, Warner C
openaire +4 more sources
Communications Biology, 2023 Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Mie Kobayashi-Ishihara +22 more
doaj +1 more source
Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression [PDF]
, 2010 Background: Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by
Scheuring Urban J +17 more
core +1 more source
Novel immunological strategies for HIV-1 eradication
Journal of Virus Eradication, 2015 Despite the significant advances in antiretroviral therapy (ART), HIV-1 is able to persist in cellular reservoirs. Preclinical studies suggest that the latent reservoir is established within days of virus exposure, even before virus can be detected in ...
B. Jülg, D.H. Barouch
doaj +1 more source