HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 HIV-1 infection remains non-curative due to the latent reservoir, primarily a small pool of resting memory CD4+ T cells bearing replication-competent provirus.
Raquel Crespo +4 more
doaj +2 more sources
A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. [PDF]
PLoS Pathogens, 2023 Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh +6 more
doaj +2 more sources
Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells [PDF]
mBioDespite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra +5 more
doaj +2 more sources
Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation [PDF]
Journal of VirologyHIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a prerequisite for
Cancan Chen +11 more
doaj +2 more sources
The mTOR Complex Controls HIV Latency [PDF]
Cell Host and Microbe, 2016 A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on antiretroviral therapy, posing a barrier to HIV eradication.
Emilie Besnard +2 more
exaly +2 more sources
SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency [PDF]
Cell Host and Microbe, 2017 Transcriptional latency of HIV is a last barrier to viral eradication. Chromatin-remodeling complexes and post-translational histone modifications likely play key roles in HIV-1 reactivation, but the underlying mechanisms are incompletely understood.
Daniela Boehm +2 more
exaly +2 more sources
PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency [PDF]
iScienceSummary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo +14 more
doaj +2 more sources
Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency. [PDF]
PLoS PathogIdentifying cellular and molecular mechanisms maintaining HIV-1 latency in the viral reservoir is crucial for devising effective cure strategies. Here we developed an innovative flow cytometry-fluorescent in situ hybridization (flow-FISH) approach for ...
Man S +4 more
europepmc +2 more sources
An Integrated Overview of HIV-1 Latency [PDF]
Cell, 2013 Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host’s ...
Ruelas, Debbie S. +3 more
core +5 more sources
Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Alexander O. Pasternak +4 more
doaj +2 more sources