Results 41 to 50 of about 66,330 (250)

Primary Cell Models of Hiv Latency [PDF]

, 2012
Purpose of review: To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.
楊宏志, YANG, HUNG-CHIH
core   +1 more source

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

Journal of Virus Eradication, 2023
A better understanding of HIV-1 latency is a research priority in HIV cure research. Conversely, little is known about the latency characteristics of HIV-2, the closely related human lentivirus.
Anne Bruggemans, Gerlinde Vansant, Paulien Van de Velde, Zeger Debyser   +3 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Viral latency and potential eradication of HIV-1 [PDF]

Expert Review of Anti-infective Therapy, 2012
Although HAART can suppress plasma viral loads to undetectable levels, individuals infected with HIV-1 harbor latent reservoirs of integrated proviruses that re-emerge upon the cessation of drug treatment. The 2012 Keystone Symposium on Frontiers in HIV Pathogenesis, Therapy and Eradication highlighted the current understanding of latent infection and ...
Kenneth A, Matreyek, Ilker, Oztop, Eric O, Freed, Alan, Engelman   +3 more
openaire   +2 more sources

The cell biology of HIV-1 latency and rebound. [PDF]

Retrovirology
AbstractTranscriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection because they are the source of the viral rebound that almost inevitably follows the interruption of antiretroviral therapy.
Mbonye U, Karn J.
europepmc   +4 more sources

Epigenetic Heterogeneity in HIV-1 Latency Establishment [PDF]

Scientific Reports, 2015
Despite prolonged antiretroviral therapy, HIV-1 persists as transcriptionally inactive proviruses. The HIV-1 latency remains a principal obstacle in curing AIDS. It is important to understand mechanisms by which HIV-1 latency is established to make the latent reservoir smaller. We present a molecular characterization of distinct populations at an early
Matsuda, Yuka, Kobayashi-Ishihara, Mie, Fujikawa, Dai, Ishida, Takaomi, Watanabe, Toshiki, Yamagishi, Makoto   +5 more
openaire   +2 more sources

Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency. [PDF]

PLoS Pathog
Identifying cellular and molecular mechanisms maintaining HIV-1 latency in the viral reservoir is crucial for devising effective cure strategies. Here we developed an innovative flow cytometry-fluorescent in situ hybridization (flow-FISH) approach for ...
Man S, Jansen J, Kroeze S, Geijtenbeek TBH, Kootstra NA.   +4 more
europepmc   +2 more sources

Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System [PDF]

, 2021
The central nervous system (CNS) is highly compartmentalized and serves as a specific site of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular populations that are infected by HIV or that harbor latent HIV ...
Hokello, Joseph, Alok Bhushan, Mudit Tyagi, Bhushan, Alok, Priya Tyagi, Sharma, Adhikarimayum Lakhikumar, Tyagi, Priya, Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Tyagi, Mudit   +9 more
core   +2 more sources

Latency and viral persistence in HIV-1 infection [PDF]

Journal of Clinical Investigation, 2000
HIV-1 infection can be controlled with combinations of antiretroviral drugs, an approach known as highly active antiretroviral therapy (HAART). In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins.
J D, Siliciano, R F, Siliciano
openaire   +2 more sources

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products [PDF]

, 2018
Natural products originating from marine and plant materials are a rich source of chemical diversity and unique antimicrobials. Using an established in vitro model of HIV-1 latency, we screened 257 pure compounds from a marine natural product library and
Andersen, Raymond J., E. Dilip de Silva, David E. Williams, Tietjen, Ian, Brumme, Zabrina L., Mark A. Brockman, Raymond J. Andersen, Zabrina L. Brumme, E. Dilip De Silva, Zabrina L. Brumme, Brockman, Mark A., David E. Williams, Ian Tietjen, Mark A. Brockman, Richard, Khumoekae, Khumoekae Richard, Raymond J. Andersen, Williams, David E., De Silva, E. Dilip   +18 more
core   +1 more source