Results 41 to 50 of about 30,551,261 (265)

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

Journal of Virus Eradication, 2023
A better understanding of HIV-1 latency is a research priority in HIV cure research. Conversely, little is known about the latency characteristics of HIV-2, the closely related human lentivirus.
Anne Bruggemans, Gerlinde Vansant, Paulien Van de Velde, Zeger Debyser   +3 more
doaj   +1 more source

BRD9 functions as an HIV-1 latency regulatory factor. [PDF]

Proc Natl Acad Sci U S A
A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs ...
Luk TY, Yim LY, Zhou R, Mo Y, Huang H, Zhao M, Dai J, Lau TT, Huang X, Lui GC, Yuen KY, Chan JF, Cheng AS, Chen Z, Chu H.   +14 more
europepmc   +2 more sources

Epigenetic Heterogeneity in HIV-1 Latency Establishment [PDF]

Scientific Reports, 2015
Despite prolonged antiretroviral therapy, HIV-1 persists as transcriptionally inactive proviruses. The HIV-1 latency remains a principal obstacle in curing AIDS. It is important to understand mechanisms by which HIV-1 latency is established to make the latent reservoir smaller. We present a molecular characterization of distinct populations at an early
Matsuda, Yuka, Kobayashi-Ishihara, Mie, Fujikawa, Dai, Ishida, Takaomi, Watanabe, Toshiki, Yamagishi, Makoto   +5 more
openaire   +2 more sources

Epigenetic Mechanisms of HIV-1 Persistence

Vaccines, 2021
Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized ...
Roxane Verdikt, Olivier Hernalsteens, Carine Van Lint   +2 more
doaj   +1 more source

NSC95397 Is a Novel HIV-1 Latency-Reversing Agent. [PDF]

Viruses, 2023
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has led to the discovery of many latency-reversing agents (LRAs) that have furthered our understanding ...
Nichols Doyle R, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI.   +5 more
europepmc   +7 more sources

Transcriptional Stochasticity as a Key Aspect of HIV-1 Latency. [PDF]

Viruses, 2023
This review summarizes current advances in the role of transcriptional stochasticity in HIV-1 latency, which were possible in a large part due to the development of single-cell approaches. HIV-1 transcription proceeds in bursts of RNA production, which stem from the stochastic switching of the viral promoter between ON and OFF states. This switching is
Damour A, Slaninova V, Radulescu O, Bertrand E, Basyuk E.   +4 more
europepmc   +4 more sources

Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]

, 2009
The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
core   +1 more source

Epigenetic Regulation of HIV-1 Latency in Astrocytes [PDF]

Journal of Virology, 2014
ABSTRACT HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes.
Srinivas D, Narasipura, Stephanie, Kim, Lena, Al-Harthi   +2 more
openaire   +2 more sources

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

EBioMedicine, 2016
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko, Elisa De Crignis, Casper Rokx, Mir Mubashir Khalid, Cynthia Lungu, Robert-Jan Palstra, Tsung Wai Kan, Charles Boucher, Annelies Verbon, Emily C. Dykhuizen, Tokameh Mahmoudi   +10 more
doaj   +1 more source

X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4⁺ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

mBio, 2020
Reversible repression of HIV-1 5′ long terminal repeat (5′-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency.
Li Ma, Qing-An Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, Jian-Hua Wang   +7 more
doaj   +1 more source