Results 51 to 60 of about 66,203 (260)

Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression [PDF]

, 2010
Background: Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by
Scheuring Urban J, Oliver G Ottmann, Dietrich, Ursula, Capalbo Gianni, Scheuring, Urban J., Ursula Dietrich, Ottmann, Oliver G., Dietrich Ursula, Gianni Capalbo, Urban J Scheuring, Hoelzer, Dieter (Prof. Dr.), Müller-Kuller Thea, Hoelzer Dieter, Ottmann Oliver G, Dieter Hoelzer, Thea Müller-Kuller, Capalbo, Gianni, Müller-Kuller, Thea   +17 more
core   +1 more source

Novel immunological strategies for HIV-1 eradication

Journal of Virus Eradication, 2015
Despite the significant advances in antiretroviral therapy (ART), HIV-1 is able to persist in cellular reservoirs. Preclinical studies suggest that the latent reservoir is established within days of virus exposure, even before virus can be detected in ...
B. Jülg, D.H. Barouch
doaj   +1 more source

Epigenetic Regulation of HIV-1 Latency in Astrocytes [PDF]

Journal of Virology, 2014
ABSTRACT HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes.
Srinivas D, Narasipura, Stephanie, Kim, Lena, Al-Harthi   +2 more
openaire   +2 more sources

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

Journal of Virus Eradication, 2023
A better understanding of HIV-1 latency is a research priority in HIV cure research. Conversely, little is known about the latency characteristics of HIV-2, the closely related human lentivirus.
Anne Bruggemans, Gerlinde Vansant, Paulien Van de Velde, Zeger Debyser   +3 more
doaj   +1 more source

Aspects on latency in HIV-1 infection

, 2010
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals.
Annica Lindkvist (548266)
core   +2 more sources

Latency and viral persistence in HIV-1 infection [PDF]

Journal of Clinical Investigation, 2000
HIV-1 infection can be controlled with combinations of antiretroviral drugs, an approach known as highly active antiretroviral therapy (HAART). In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins.
J D, Siliciano, R F, Siliciano
openaire   +2 more sources

The cell biology of HIV-1 latency and rebound. [PDF]

Retrovirology
AbstractTranscriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection because they are the source of the viral rebound that almost inevitably follows the interruption of antiretroviral therapy.
Mbonye U, Karn J.
europepmc   +4 more sources

Viral latency and potential eradication of HIV-1 [PDF]

Expert Review of Anti-infective Therapy, 2012
Although HAART can suppress plasma viral loads to undetectable levels, individuals infected with HIV-1 harbor latent reservoirs of integrated proviruses that re-emerge upon the cessation of drug treatment. The 2012 Keystone Symposium on Frontiers in HIV Pathogenesis, Therapy and Eradication highlighted the current understanding of latent infection and ...
Kenneth A, Matreyek, Ilker, Oztop, Eric O, Freed, Alan, Engelman   +3 more
openaire   +2 more sources

Epigenetic Heterogeneity in HIV-1 Latency Establishment [PDF]

Scientific Reports, 2015
Despite prolonged antiretroviral therapy, HIV-1 persists as transcriptionally inactive proviruses. The HIV-1 latency remains a principal obstacle in curing AIDS. It is important to understand mechanisms by which HIV-1 latency is established to make the latent reservoir smaller. We present a molecular characterization of distinct populations at an early
Matsuda, Yuka, Kobayashi-Ishihara, Mie, Fujikawa, Dai, Ishida, Takaomi, Watanabe, Toshiki, Yamagishi, Makoto   +5 more
openaire   +2 more sources

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. [PDF]

, 2022
The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1.
Pasternak, Alexander, Passaes, Caroline Pereira Bittencourt, Cicilionyte, Aurelija, Le Douce, Valentin, Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Berkhout, Ben, Delacourt, Nadège, Pasternak, Alexander O., Verdikt, Roxane, Plant, Estelle, Vanhulle, Caroline, Avettand-Fenoel, V. ronique, Pasternak, Alexander O, Gautier, Virginie, Bendoumou, Maryam, Santangelo, Marion, Schwartz, Christian, Rohr, Olivier, Rouzioux, Christine, Nestola, Lorena, Sáez-Cirión, Asier, Avettand-Fenoel, Veronique, Ait-Ammar, Amina, Douce, Valentin Le, Necsoi, Coca, Bouchat, Sophie, Corazza, Francis, Bizet, Martin, Fuks, François   +30 more
core   +1 more source