Results 51 to 60 of about 30,551,261 (265)
The cell biology of HIV-1 latency and rebound. [PDF]
RetrovirologyAbstractTranscriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection because they are the source of the viral rebound that almost inevitably follows the interruption of antiretroviral therapy.
Mbonye U, Karn J.
europepmc +4 more sources
Latency and viral persistence in HIV-1 infection [PDF]
Journal of Clinical Investigation, 2000 HIV-1 infection can be controlled with combinations of antiretroviral drugs, an approach known as highly active antiretroviral therapy (HAART). In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins.
J D, Siliciano, R F, Siliciano
openaire +2 more sources
Viral latency and potential eradication of HIV-1 [PDF]
Expert Review of Anti-infective Therapy, 2012 Although HAART can suppress plasma viral loads to undetectable levels, individuals infected with HIV-1 harbor latent reservoirs of integrated proviruses that re-emerge upon the cessation of drug treatment. The 2012 Keystone Symposium on Frontiers in HIV Pathogenesis, Therapy and Eradication highlighted the current understanding of latent infection and ...
Kenneth A, Matreyek +3 more
openaire +2 more sources
HIV-1 latency in proliferating T cells [PDF]
, 2013 In this thesis we focus on the ability of HIV-1 to establish a latent provirus in proliferating T cells and on how the silent provirus can be activated from latency. HIV-1 latency is a major barrier towards virus eradication from the infected individual.
van der Sluis, R.M. +1 more
core +24 more sources
PLoS Pathogens, 2023 Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh +6 more
doaj +1 more source
Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis
Cellular Physiology and Biochemistry, 2015 Background/Aims: The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis
Zongxing Yang +6 more
doaj +1 more source
Emerging Microbes and Infections, 2022 HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen +12 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
HTLV-1 Tax activates HIV-1 transcription in latency models. [PDF]
, 2017 HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription.
Amilcar Tanuri +11 more
core +1 more source
Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal
Viruses, 2021 While suppressive antiretroviral therapy can effectively limit HIV-1 replication and evolution, it leaves behind a residual pool of integrated viral genomes that persist in a state of reversible nonproductive infection, referred to as the HIV-1 reservoir.
Suhui Zhao, Athe Tsibris
doaj +1 more source