Results 61 to 70 of about 30,551,261 (265)

Primary Cell Models of Hiv Latency

, 2012
Purpose of review: To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.
楊宏志, YANG, HUNG-CHIH
core   +1 more source

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.

PLoS Pathogens, 2016
The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White, Bastiaan Moesker, Nadejda Beliakova-Bethell, Laura J Martins, Celsa A Spina, David M Margolis, Douglas D Richman, Vicente Planelles, Alberto Bosque, Christopher H Woelk   +9 more
doaj   +1 more source

Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA

, 2011
BACKGROUND: Early initiation of combination antiretroviral therapy (ART) during primary HIV-1 infection may prevent the establishment of large viral reservoirs, possibly resulting in improved control of plasma viraemia rebound after ART cessation ...
Niederoest, B, Fischer, M., Battegay, Manuel, Günthard, Huldrych F, Fischer, M, Gianella, S., Weber, R, Vernazza, P, Cavassini, M., Gianella, S, Swiss HIV Cohort Study,, Bernasconi, E, Cavassini, M, Battegay, M., Vernazza, P., Joos, B., Rauch, A., Bernasconi, Enos, Weber, R., von Wyl, Viktor, Günthard, Huldrych F., Niederoest, B., Rauch, A, von Wyl, V., Hirschel, Bernard, Rauch, Andri, Joos, B, Günthard, H.F., Joos, Beda, Günthard, H F, Hirschel, B, Gianella, Sara, Niederoest, Barbara, Vernazza, Pietro, Battegay, M, Fischer, Marek, Weber, Rainer, von Wyl, V, Hirschel, B., Cavassini, Matthias, Bernasconi, E.   +40 more
core   +1 more source

Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]

, 2007
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Michael Simpson, Roy D. Dar, Leor Weinberger   +2 more
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. [PDF]

, 2013
The study estimated the prevalence of HIV-1 intra-subtype recombinant variants among female bar and hotel workers in Tanzania. While intra-subtype recombination occurs in HIV-1, it is generally underestimated.
Kiwelu, Ireen E, Baca Jeannie, Vladimir Novitsky, Essex, M., Baca, Jeannie, Mary F McLane, Kapiga, Saidi H., Novitsky, Vladimir, Saidi H Kapiga, McLane, Mary F, M Essex, Ireen E Kiwelu, McLane, Mary, Essex, M, Jeannie Baca, Kiwelu Ireen E., Novitsky Vladimir, Manongi, Rachel, Manongi Rachel, Rachel Manongi, Kapiga, Saidi H, Margolin Lauren, Essex M., John Shao, Kiwelu, Ireen E., Noel Sam, Sam Noel, Lauren Margolin, McLane Mary F., Margolin, Lauren, Sam, Noel, Shao John, Kapiga Saidi H., Shao, John   +33 more
core   +1 more source

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. [PDF]

, 2022
The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1.
Pasternak, Alexander, Passaes, Caroline Pereira Bittencourt, Cicilionyte, Aurelija, Le Douce, Valentin, Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Berkhout, Ben, Delacourt, Nadège, Pasternak, Alexander O., Verdikt, Roxane, Plant, Estelle, Vanhulle, Caroline, Avettand-Fenoel, V. ronique, Pasternak, Alexander O, Gautier, Virginie, Bendoumou, Maryam, Santangelo, Marion, Schwartz, Christian, Rohr, Olivier, Rouzioux, Christine, Nestola, Lorena, Sáez-Cirión, Asier, Avettand-Fenoel, Veronique, Ait-Ammar, Amina, Douce, Valentin Le, Necsoi, Coca, Bouchat, Sophie, Corazza, Francis, Bizet, Martin, Fuks, François   +30 more
core   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]

, 2012
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Eberle, Josef, Gürtler, Lutz
core   +1 more source

Dynamic Observation of Lacy Pattern Formation in a Bone Tissue Model Using Liquid Phase Scanning Transmission Electron Microscopy

Advanced Functional Materials, EarlyView.
Here, we establish a low‐dose liquid‐phase electron microscopy workflow for real‐time observation of biological processes in hydrated conditions. Beam damage is reduced by imaging only 20% of the pixels and reconstructing the complete image using an inpainting algorithm.
Luco Rutten, Avital Wagner, Rona Roverts, Luco Buise, Ben Joosten, Anat Akiva, Elena Macías‐Sánchez, Nico Sommerdijk   +7 more
wiley   +1 more source