Results 61 to 70 of about 66,330 (250)

Shocking HIV-1 with immunomodulatory latency reversing agents. [PDF]

, 2021
The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to ...
Kula-Pacurar, Anna, Van Lint, Carine, Rodari, Anthony, Darcis, Gilles   +3 more
core   +1 more source

HIV-1 latency in actively dividing human T cell lines [PDF]

, 2008
Background Eradication of HIV-1 from an infected individual cannot be achieved by current drug regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy and are able to replenish systemic infection ...
Berkhout Ben, Westerhout Ellen M, van Gerven, Marja L., Ben Berkhout, Rienk E Jeeninga, Westerhout, Ellen M., Jeeninga Rienk E, Jeeninga, Rienk E., Berkhout, Ben, van Gerven Marja L, Ellen M Westerhout, Marja L van Gerven   +11 more
core   +1 more source

Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal

Viruses, 2021
While suppressive antiretroviral therapy can effectively limit HIV-1 replication and evolution, it leaves behind a residual pool of integrated viral genomes that persist in a state of reversible nonproductive infection, referred to as the HIV-1 reservoir.
Suhui Zhao, Athe Tsibris
doaj   +1 more source

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir [PDF]

, 2016
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-Treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-Treated patients to make latent cells visible to the ...
De Wit, S, Rohr, O, Rohr, O. (Olivier), Van Lint, C. (Carine), De Wit, S. (Stéphane), Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Rouzioux, C, Vanhulle, C. (Caroline), Bouchat, S, Kula, Anna, Delacourt, Nadège, Bouchat, S. (Sophie), Vanhulle, Caroline, Delacourt, N, Rouzioux, C. (Christine), Darcis, G. (Gilles), Rohr, Olivier, Rouzioux, Christine, Van Driessche, Benoît, Avettand-Fenoel, Veronique, Vanhulle, C, Avettand-Fenoel, V. (Véronique), Van Driessche, B, Delacourt, N. (Nadège), Bouchat, Sophie, Van Driessche, B. (Benoit), Kula, A. (Anna)   +28 more
core   +1 more source

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.

PLoS Pathogens, 2016
The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White, Bastiaan Moesker, Nadejda Beliakova-Bethell, Laura J Martins, Celsa A Spina, David M Margolis, Douglas D Richman, Vicente Planelles, Alberto Bosque, Christopher H Woelk   +9 more
doaj   +1 more source

Ephedrine enhances HIV-1 reactivation from latency through elevating tumor necrosis factor receptor II (TNFRII) expression

Heliyon, 2019
HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The latently-infected cells, or reservoir cells, are transcriptionally absent and invisible to
Jutatip Panaampon, Eriko Kudo, Ryusho Kariya, Seiji Okada   +3 more
doaj   +1 more source

CpG methylation controls reactivation of HIV from latency. [PDF]

PLoS Pathogens, 2009
DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune responses and antiretroviral drugs.
Jana Blazkova, Katerina Trejbalova, Françoise Gondois-Rey, Philippe Halfon, Patrick Philibert, Allan Guiguen, Eric Verdin, Daniel Olive, Carine Van Lint, Jiri Hejnar, Ivan Hirsch   +10 more
doaj   +1 more source

De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]

, 2009
The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Sawtell, N.M., Thompson, R.L., Richard L Thompson, Chris M Preston, Nancy M Sawtell, Preston, C.M.   +5 more
core   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]

, 2007
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Michael Simpson, Roy D. Dar, Leor Weinberger   +2 more
core   +1 more source