Results 81 to 90 of about 66,203 (260)
Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective
Advanced Science, EarlyView.Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok +4 more
wiley +1 more source
Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?
Viruses, 2021 AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still unachievable. A critical burden of AIDS therapy is the evasive nature of HIV-1 in face of host immune responses, the so-called “latency.” Recently, a ...
Thanarat Salahong +2 more
doaj +1 more source
Racism and racial disparities in firearm violence: A scoping review
American Journal of Community Psychology, EarlyView.Abstract Firearm violence (i.e., interpersonal, police firearm violence) disproportionately affects racially minoritized communities. Researchers recently shifted their focus from race to racism to better understand the factors that contribute to racial disparities in firearm violence.
Daniel B. Lee +8 more
wiley +1 more source
An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review
, 2023 Peter W Ramirez,1 Christina Pantoja,1 Nadejda Beliakova-Bethell2,3 1Department of Biological Sciences, California State University, Long Beach, CA, USA; 2VA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, CA, USA ...
Pantoja C +2 more
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Humanized immune system animal models and their recent applications
Animal Models and Experimental Medicine, EarlyView.In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli +6 more
wiley +1 more source
Latency reversal and viral clearance to cure HIV-1 [PDF]
Science, 2016 Next steps toward curing HIV-1 Since the discovery of HIV-1 more than 30 years ago, prevention and treatment strategies have dominated the research agenda. More recently, however, scientists are also focusing their efforts toward finding a cure. Margolis et al.
David M, Margolis +3 more
openaire +2 more sources
Delineating gender/sex‐related studies through bibliometric analysis
Journal of the Association for Information Science and Technology, EarlyView.Abstract The multidisciplinary and socially grounded nature of Women's/Gender/Feminist Studies poses unique challenges for bibliometric analysis, as it extends beyond conventional disciplinary boundaries. This paper makes three key contributions: (1) We propose a novel retrieval method for constructing a corpus of scholarly documents in research areas ...
Natsumi S. Shokida +2 more
wiley +1 more source
Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions
Biotechnology and Bioengineering, EarlyView.ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
wiley +1 more source
Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins
Clinical Epigenetics, 2018 HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan +4 more
doaj +1 more source
HIV-1 latency in proliferating T cells [PDF]
, 2013 In this thesis we focus on the ability of HIV-1 to establish a latent provirus in proliferating T cells and on how the silent provirus can be activated from latency. HIV-1 latency is a major barrier towards virus eradication from the infected individual.
van der Sluis, R.M. +1 more
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