Results 101 to 110 of about 30,551,261 (265)

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency [PDF]

, 2011
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral latency established within the host genome remains largely ...
Margolis, David M., Choudhary, Shailesh K., David M. Margolis, Shailesh K. Choudhary   +3 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.

PLoS Pathogens, 2019
The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are ...
Zichong Li, Jun Wu, Leonard Chavez, Rebecca Hoh, Steven G Deeks, Satish K Pillai, Qiang Zhou   +6 more
doaj   +1 more source

Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes [PDF]

, 2012
BACKGROUND: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups.
Thomas Bodmer, Gagneux, Sebastien, Bodmer, Thomas, Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups, Schrenzel, J., Bottger, E. C., Schrenzel Jacques, Jean-Paul Janssens (174301), Cavassini Matthias, Matthias Egger, Enos Bernasconi (174329), Jacques Schrenzel, Egger, M., Böttger Erik C., Schrenzel, Jacques, Matthias Egger (24558), Böttger, E.C., Jan Fehr (174310), Fehr Jan, Janssens, J. P., Bodmer Thomas, Bernasconi, E., Gagneux, S., Fenner, Lukas, Egger, Matthias, Enos Bernasconi, Egger Matthias, Hoffmann, Matthias, Erik C. Böttger (174343), Cavassini, M., Matthias Hoffmann, Jacques Schrenzel (22586), Janssens, J.P., Böttger, Erik C, Helbling, Peter, Matthias Cavassini (146654), Gagneux Sebastien, Fenner, L., Matthias Hoffmann (174320), Peter Helbling (174346), Helbling, P., Bernasconi, Enos, Jan Fehr, Erik C Böttger, Thomas Bodmer (174337), Lukas Fenner, Fenner Lukas, Fehr, Jan, for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculo,, Janssens, Jean-Paul, Helbling Peter, Bernasconi Enos, Sebastien Gagneux (149824), Janssens Jean-Paul, Hoffmann, M., Hoffmann Matthias, Sebastien Gagneux, Peter Helbling, Lukas Fenner (149822), Jean-Paul Janssens, Fehr, J., Cavassini, Matthias, Bodmer, T., Matthias Cavassini   +63 more
core   +3 more sources

Discrete components of stress impact trajectories of childhood irritability but not adolescent mental health outcomes

JCPP Advances, EarlyView.
Thick red line indicates positive mixture effect of stressors predicting high irritability class. Maternal demoralization, material hardship, maternal perceived stress, and intimate partner violence contributed to the mixture effect (thick borders on boxes).
Mariah DeSerisy, Huiyu Yang, Jacob W. Cohen, David Pagliaccio, Julie B. Herbstman, Bradley S. Peterson, Frederica P. Perera, Virginia Rauh, Amy E. Margolis   +8 more
wiley   +1 more source

HIV-1 Transcription and Latency in the Spotlight

Viruses
At every integrated HIV-1 genome, there is a transcriptional cycle that ultimately shapes proviral fate [...]
openaire   +3 more sources

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. [PDF]

, 2010
BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression.
van Loggerenberg, Francois, Passmore, Jo-Ann Shelley., Burgers, Wendy A, Passmore, Jo-Ann S., Loggerenberg, Francois van, Bebell, Lisa M., Roberts, Lindi., Mlisana, Koleka Patience., Burgers, Wendy A., Passmore, Jo-Ann S, Roberts, Lindi, Mlisana, Koleka, Djoba Siawaya, Joel Fleury., Abdool Karim, Salim Safurdeen., Djoba Siawaya, Joel F., Williamson, Carolyn., Little, Francesca., Abdool Karim, Quarraisha, Mlisana, Koleka P., Djoba Siawaya, Joel F, Bebell, Lisa M, Karim, Quarraisha Abdool, Williamson, Carolyn, Walzl, Gerhard, Abdool Karim, Quarraisha., Abdool Karim, Salim, van Loggerenberg, Francois., Karim, Salim S Abdool, Little, Francesca, Walzl, Gerhard.   +29 more
core   +1 more source

Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi, Nishant Pandey, Sushan Ghimire, Avilasha Shah, Anurag Tiwari, Salina Subedi, Deepika Neupane   +6 more
wiley   +1 more source

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells

iScience
Summary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj   +1 more source

The CCR5-antagonist Maraviroc reverses HIV-1 latency in vitro alone or in combination with the PKC-agonist Bryostatin-1

Scientific Reports, 2017
A potential strategy to cure HIV-1 infection is to use latency reversing agents (LRAs) to eliminate latent reservoirs established in resting CD4+ T (rCD4+) cells.
María Rosa López-Huertas, Laura Jiménez-Tormo, Nadia Madrid-Elena, Carolina Gutiérrez, Sara Rodríguez-Mora, Mayte Coiras, José Alcamí, Santiago Moreno   +7 more
doaj   +1 more source