Results 101 to 110 of about 66,203 (260)
Transient-mediated fate determination in a transcriptional circuit of HIV
, 2007 Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Michael Simpson +2 more
core
Journal of Clinical Ultrasound, EarlyView.In children with presumptive tuberculosis, comprehensive point‐of‐care (cPOCUS) identified key thoracic abnormalities with high specificity and excellent inter‐reader reliability. Although diagnostic sensitivity was modest and examinations often incomplete, cPOCUS shows promise as a complementary, radiation‐free imaging tool.
Isabelle Munyangaju +17 more
wiley +1 more source
, 2010 Type I interferons (IFNα and β) are induced directly in response to viral infection, resulting in an antiviral state for the cell. In vitro studies have shown that IFNα is a potent inhibitor of viral replication; however, its role in HIV-1 infection is ...
McKnight, A +5 more
core +1 more source
JCPP Advances, EarlyView.Abstract Background Nationally representative mental health data in adolescents from low‐ and middle‐income countries (LMICs) are scarce. This study aimed to examine mental health and wellbeing indicators amongst adolescents in 12 LMICs across Eastern and Southern Africa and Southeast Asia. Methods We conducted a secondary analysis of data involving 12,
Ariadna Albajara Sáenz +6 more
wiley +1 more source
HIV-1 Tat: Role in Bystander Toxicity
Frontiers in Cellular and Infection Microbiology, 2020 HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its role as the transactivator of HIV transcription is well-established, other non-viral replication-associated functions have been described in several HIV ...
David Ajasin, Eliseo A. Eugenin
doaj +1 more source
Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency
, 2011 HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral latency established within the host genome remains largely ...
Margolis, David M. +3 more
core +1 more source
Issues in Implementing Latency Insensitive Protocols [PDF]
, 2004 The latency insensitive protocols (LIP), which are designed to improve the performance of systems-on-chip, were refined. The refined protocol was validated by using many proof-of-concept examples, that comprised of various combinations of feedforward and
L. Macchiarulo +3 more
core +1 more source
Journal of Traumatic Stress, EarlyView.Abstract Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) individuals experience elevated rates of trauma exposure, minority stress, and posttraumatic stress disorder (PTSD). Yet, research examining how geographic location and LGBTQ+ identity shape PTSD outcomes is scant, particularly studies considering structural facilitators and barriers ...
Emily A. Kenyon +6 more
wiley +1 more source
Journal of Traumatic Stress, EarlyView.Abstract Bisexual and other multigender‐attracted (e.g., pansexual, queer) people (bi+) report disproportionately high posttraumatic stress symptoms (PTSS) linked to a high frequency of discrimination and general trauma exposure. Bi+ people of color (POC) may be particularly vulnerable to PTSS given exposure to intersectional discrimination (e.g ...
Roberto Rentería +5 more
wiley +1 more source
PLoS Pathogens, 2019 The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are ...
Zichong Li +6 more
doaj +1 more source