Results 101 to 110 of about 66,330 (250)

Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency [PDF]

, 2017
Human immunodeficiency virus type 1 (HIV-1) Tat is a virus-encoded trans-activator that plays a central role in viral transcription. We used our recently developed parallel analysis of in vitro translated open reading frames (ORFs) (PLATO) approach to ...
Weili Kong, Huachao Huang, Netty Santoso, Derek Power, Maxime Jean, Jian Zhu   +5 more
core   +1 more source

Identification of unrecognized host factors promoting HIV-1 latency. [PDF]

, 2020
To counter HIV latency, it is important to develop a better understanding of the full range of host factors promoting latency. Their identification could suggest new strategies to reactivate latent proviruses and subsequently kill the host cells ("shock ...
Hajian, Cyrus, Warner C Greene, Cyrus Hajian, Li, Zichong, Greene, Warner C, Zichong Li   +5 more
core   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

HIV-1 Tat: Role in Bystander Toxicity

Frontiers in Cellular and Infection Microbiology, 2020
HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its role as the transactivator of HIV transcription is well-established, other non-viral replication-associated functions have been described in several HIV ...
David Ajasin, Eliseo A. Eugenin
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Characterizing Combined Central and Peripheral Demyelination—Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Combined central and peripheral demyelination (CCPD) is a rare dysimmune disorder sharing features with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Direct comparisons of central and peripheral diagnostic findings across these entities remain limited. We, therefore, performed a
N. Dubuisson, A. Kassab, P. Y. K. Van den Bergh, A. F. J. E. Vrancken, W. L. van der Pol, L. H. van den Berg, H. S. Goedee   +6 more
wiley   +1 more source

Issues in Implementing Latency Insensitive Protocols [PDF]

, 2004
The latency insensitive protocols (LIP), which are designed to improve the performance of systems-on-chip, were refined. The refined protocol was validated by using many proof-of-concept examples, that comprised of various combinations of feedforward and
L. Macchiarulo, Casu, Mario Roberto, Macchiarulo, Luca, M.R. Casu   +3 more
core   +1 more source

Optimal Control Analysis of Vertically Transmitted Infectious Diseases With Saturated Incidence and Nonlinear Treatment

Optimal Control Applications and Methods, EarlyView.
Schematic representation of the proposed disease transmission model incorporating vertical transmission, saturated incidence, and nonlinear treatment. The study combines theoretical analysis, bifurcation and stability investigations, and optimal control techniques to evaluate prevention and treatment interventions.
Oludolapo A. Olanrewaju, Sulaimon F. Abimbade   +1 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source