Results 121 to 130 of about 66,203 (260)

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Queering Institutional Milestones in Elite Higher Education: Queer Perspectives on Princeton University and Coeducation (1960–1980)

Gender &History, EarlyView.
ABSTRACT A new archive of oral history interviews from LGBTQIA‐identified alumni, faculty and staff reveals the complex ways that queer and transgender students understood, experienced and remembered the long transition from single‐sex to coeducation at Princeton University.
Ezelle Sanford III, Judy Jarvis, Eric Anglero   +2 more
wiley   +1 more source

Reversal of HIV-1 latency with anti-microRNA inhibitors [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Human immunodeficiency virus type 1 (HIV-1) latency is achieved when host cells contain integrated proviral DNA but do not produce viral particles. The virus remains in resting CD4 T-lymphocytes, evading host immune surveillance and antiviral drugs. When resting cells are activated, infectious viral particles are produced.
openaire   +2 more sources

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathwayResearch in context

EBioMedicine, 2019
Background: The latent HIV-1 reservoir in treated patients primarily consists of resting memory CD4+ T cells. Stimulating the T-cell receptor (TCR), which facilitates transition of resting into effector T cells, is the most effective strategy to purge ...
Thijs van Montfort, Renée van der Sluis, Gilles Darcis, Doyle Beaty, Kevin Groen, Alexander O. Pasternak, Georgios Pollakis, Monique Vink, Ellen M. Westerhout, Mohamed Hamdi, Margreet Bakker, Boas van der Putten, Suzanne Jurriaans, Jan H. Prins, Rienk Jeeninga, Adri A.M. Thomas, Dave Speijer, Ben Berkhout   +17 more
doaj   +1 more source

Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency

, 2017
Human immunodeficiency virus type 1 (HIV-1) Tat is a virus-encoded trans-activator that plays a central role in viral transcription. We used our recently developed parallel analysis of in vitro translated open reading frames (ORFs) (PLATO) approach to ...
Weili Kong, Huachao Huang, Netty Santoso, Derek Power, Maxime Jean, Jian Zhu   +5 more
core   +1 more source

Impact of the Ku Complex on HIV-1 Expression and Latency

PLoS ONE, 2013
Ku, a cellular complex required for human cell survival and involved in double strand break DNA repair and multiple other cellular processes, may modulate retroviral multiplication, although the precise mechanism through which it acts is still controversial.
Gwenola Manic, Aurélie Maurin-Marlin, Fanny Laurent, Ilio Vitale, Sylvain Thierry, Olivier Delelis, Philippe Dessen, Michelle Vincendeau, Christine Leib-Mösch, Uriel Hazan, Jean-François Mouscadet, Stéphanie Bury-Moné   +11 more
openaire   +4 more sources

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source