Results 121 to 130 of about 30,551,261 (265)

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

PLoS Pathogens, 2009
Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T cells of infected persons treated with highly active antiretroviral therapy (HAART). This reservoir must be eliminated for the clearance of infection. Using a cDNA library screen, we have identified methyl-CpG binding domain protein 2 (MBD2) as a regulator of ...
Kauder, Steven E, Bosque, Alberto, Lindqvist, Annica, Planelles, Vicente, Verdin, Eric   +4 more
openaire   +6 more sources

Second European Round Table on the Future Management of HIV

Journal of Virus Eradication, 2015
The Second European Round Table on the Future Management of HIV took place in Barcelona, 10–11 October 2014 and focused on the HIV-1 reservoir, strategies for HIV cure and primary HIV infection (PHI).
Casper Rokx, Douglas D. Richman, Michaela Müller-Trutwin, Guido Silvestri, Jan Lunzen, van, Saye Khoo, Mathias Lichterfeld, Marcus Altfeld, Carlo Federico Perno, Peter W. Hunt, Paddy Mallon, Jürgen K. Rockstroh, Anton L. Pozniak, Bonaventura Clotet, Charles A.B. Boucher   +14 more
doaj   +1 more source

De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]

, 2009
The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Sawtell, N.M., Thompson, R.L., Richard L Thompson, Chris M Preston, Nancy M Sawtell, Preston, C.M.   +5 more
core   +1 more source

The Mitigating Role of Managerial Ability in ESG Decoupling

Sustainable Development, EarlyView.
ABSTRACT Does managerial competence widen or bridge the gap between environmental, social, and governance (ESG) disclosures and actual performance? This paper explores the relationship between CEO ability and corporate decoupling regarding sustainability issues.
Isabel‐María García‐Sánchez, Rizwan Ali, Alejandra García‐Sánchez, Ramiz ur Rehman   +3 more
wiley   +1 more source

The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin [PDF]

, 2010
Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles. Several mammalian viruses have evolved countermeasures that inactivate tetherin, with the prototype being the HIV-1 Vpu ...
Wilson, Sam J., Calvi Alessandra, Towers, G.J., Trinity Zang, Stuart J D Neil, Claire Pardieu, Sam J Wilson, Wilson Sam J., Pardieu, C, Vigan, R., Zang, T, Towers, Greg J, Pardieu, Claire, Wilson, SJ, Neil Stuart J. D., Jung, J.U., Wilson, Sam J, Raphaël Vigan, Kellam, P, Pardieu, C., Towers, GJ, Neil, SJD, Bieniasz, P., Greg J Towers, Kellam, P., Neil, Stuart JD, Paul Kellam, Zang Trinity, Bieniasz Paul, Zang, T., Neil, S.J.D., Bieniasz, Paul, Alessandra Calvi, Towers Greg J., Vigan, Raphaël, Towers, Greg J., Wilson, S.J., Kellam Paul, Paul Bieniasz, Pardieu Claire, Calvi, A, Calvi, Alessandra, Neil, Stuart J. D., Kellam, Paul, Calvi, A., Bieniasz, P, Vigan Raphaël, Vigan, R, Zang, Trinity   +48 more
core   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

“Who Is Watching me?”: Recovering the Grammar of Stigma in Interaction

Symbolic Interaction, EarlyView.
This article offers a praxeological respecification of stigma. I argue that the term “stigma” is a category term and glossing device, used to gather together and stand in for a diverse range of interactional experiences, including, but not limited to, degradation, discrediting, discrimination, marginalization, and being demeaned.
Phil Hutchinson
wiley   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
doaj   +1 more source

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source