Results 131 to 140 of about 66,330 (250)

Regulation of HIV-1 latency by basal transcription [PDF]

, 2013
HIV/AIDS is undoubtedly one of mankind’s most pressing health concerns. Currently, there are ~34 million people infected worldwide, with ~3 million new infections and ~2 million deaths every year.
Dahabieh, Matthew Solomon
core  

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
doaj   +1 more source

UltRaSoUnd‐guided evaLuAtion of metabolic health in a cohort of midlife women with HIV: The URSULA study

HIV Medicine, EarlyView.
Abstract Objectives We aimed to determine the prevalence of metabolic disorders, liver steatosis and metabolic dysfunction‐associated steatotic liver disease (MASLD) in a cohort of middle‐aged women with HIV (WoWH) and to explore associations between liver steatosis, visceral fat depots and carotid atherosclerosis.
Mariacristina Poliseno, Davide Capruzzi, Antonio Cianciaruso, Nicola Colavito, Felicia Dalitto, Vincenzo Giliberti, Vittoria Lobalsamo, Giuliana Metrangolo, Marica Noviello, Alessandra Vigna, Maurizio Zarcone, Francesco Di Gennaro, Vincenzo Ostilio Palmieri, Annalisa Saracino   +13 more
wiley   +1 more source

Sexually Transmitted Infection Prevalence and Determinants Among Sexual Health Clinic Attendees in Bucharest, Romania

International Journal of Dermatology, EarlyView.
Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Nodular Secondary Syphilis: Systematic Review of an Underrecognized Clinical Phenotype

International Journal of Dermatology, EarlyView.
Nodular secondary syphilis is a rare and often misdiagnosed manifestation of secondary syphilis with diverse clinical and histopathologic features. This systematic review of 144 cases highlights its frequent association with ulceration, generalized skin involvement, and HIV infection, emphasizing the importance of considering syphilis in the ...
Jacopo Tartaglia, Monica Ponzano, Alvise Sernicola, Roberto Mazzetto, Mauro Alaibac   +4 more
wiley   +1 more source

Medical Knowledge Integration Into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

International Statistical Review, EarlyView.
Summary The goal of precision medicine is to provide individualised treatment at each stage of chronic diseases, a concept formalised by dynamic treatment regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from clinical data to enhance therapeutic effectiveness.
Sophia Yazzourh, Nicolas Savy, Philippe Saint‐Pierre, Michael R. Kosorok   +3 more
wiley   +1 more source

Health Screening and Post‐Arrival Services for Refugee Children From Afghanistan

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To examine refugee health screening and services for Afghan children in the unique context of emergency expedited humanitarian resettlement in Melbourne, Australia. Methods Retrospective audit of Afghan children who attended a specialist child refugee health service between August 2021–April 2024. Results Participants included 218 children
Amy Williamson, Eva Sudbury, Rija Khanal, Jade Woon, Jennifer Schaefer, Georgia Paxton   +5 more
wiley   +1 more source

Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency [PDF]

Background: Current latency-reversing agents (LRAs) employed in the “shock-and-kill” strategy primarily focus on relieving epigenetic and transcriptional blocks to reactivate the latent HIV-1.
Van Lint, Carine, Maryam Bendoumou, Selberg, Simona, Alexander O. Pasternak, De Wit, Stéphane, Heng-Chang Chen, Coca Necsoi, Stéphane De Wit, Chen, Heng Chang, Pasternak, Alexander O., Chen, Heng-Chang, Antoine Dutilleul, -, Haider Ali, Karelson, Mati, Wadas, Jakub, Dutilleul, Antoine, Mati Karelson, Anna Kula-Pacurar, Bendoumou, Maryam, Carine Van Lint, Avettand-Fenoël, Veronique, Kankuri, Esko, Jakub Wadas, Lalik, Kamil, Veronique Avettand-Fenoël, Ali, Haider, Marcello, Alessandro, Simona Selberg, Nestola, Lorena, Paolo Maiuri, Haider Ali, Esko Kankuri, Pyrc, Krzysztof, Alessandro Marcello, Kula-Pacurar, Anna, Necsoi, Coca, Kamil Lalik, Maiuri, Paolo, Krzysztof Pyrc, Lorena Nestola   +39 more
core   +2 more sources

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source