Results 11 to 20 of about 66,203 (260)

HIV-1 Latency in Monocytes/Macrophages [PDF]

Viruses, 2014
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been ...
Wasim Abbas, Georges Herbein
exaly   +6 more sources

Latency: the hidden HIV-1 challenge [PDF]

Retrovirology, 2006
Eradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection ...
Marcello Alessandro
doaj   +4 more sources

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy? [PDF]

Viruses
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara, Yasuko Tsunetsugu-Yokota   +1 more
doaj   +3 more sources

HIV-1 Latency and Latency Reversal: Does Subtype Matter? [PDF]

Viruses, 2019
Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide.
Indra Sarabia, Alberto Bosque
exaly   +4 more sources

NSC95397 Is a Novel HIV-1 Latency-Reversing Agent. [PDF]

Viruses, 2023
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the kick and kill (also called shock and kill) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has led ...
Nichols Doyle R, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI.   +5 more
europepmc   +8 more sources

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
info:eu-repo/semantics ...
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +7 more sources

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency [PDF]

mBio, 2021
To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi   +13 more
doaj   +2 more sources

Molecular Understanding of HIV-1 Latency [PDF]

Advances in Virology, 2012
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough in the treatment of HIV-1 infection and has also a powerful tool to upset the equilibrium of viral production and HIV-1 pathogenesis.
W. Abbas, G. Herbein
doaj   +4 more sources

BRD9 functions as an HIV-1 latency regulatory factor. [PDF]

Proc Natl Acad Sci U S A
A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs ...
Luk TY, Yim LY, Zhou R, Mo Y, Huang H, Zhao M, Dai J, Lau TT, Huang X, Lui GC, Yuen KY, Chan JF, Cheng AS, Chen Z, Chu H.   +14 more
europepmc   +2 more sources

Modulation of IRF7-driven transcription as a strategy to control HIV-1 latency [PDF]

Frontiers in Immunology
BackgroundThe persistence of latent HIV-1 reservoirs remains a major barrier to achieving a cure for HIV. While latency-reversing agents (LRAs) have been extensively studied, latency-promoting agents (LPAs) offer a complementary strategy to silence viral
Ifeanyi Jude Ezeonwumelu, Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Edurne Garcia-Vidal, Eudald Felip, Eudald Felip, Eudald Felip, Sara Cabrero-de las Heras, Sara Cabrero-de las Heras, Bonaventura Clotet, Bonaventura Clotet, Roger Badia, Roger Badia, Ester Ballana, Ester Ballana, Ester Ballana, Eva Riveira-Muñoz, Eva Riveira-Muñoz, Maria Nevot, Maria Nevot   +19 more
doaj   +2 more sources