Results 11 to 20 of about 30,551,261 (265)

HIV-1 Latency in Monocytes/Macrophages [PDF]

Viruses, 2014
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been ...
Amit Kumar, Wasim Abbas, Georges Herbein
doaj   +6 more sources

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy? [PDF]

Viruses
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara, Yasuko Tsunetsugu-Yokota   +1 more
doaj   +3 more sources

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
info:eu-repo/semantics ...
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +7 more sources

[Viral latency of HIV-1] [PDF]

Virologie (Montrouge, France), 2019
Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs.
Van Lint, Carine, Bouchat, Sophie
core   +3 more sources

Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency [PDF]

Medecine sciences : M/S, 2010
peer reviewedThe introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1.
Olivier Rohr, Schwartz, C. (Christian), Rohr, O. (Olivier), Laetitia Redel, Le Douce, Valentin, Aunis, D. (Dominique), Valentin Le Douce, Redel, L. (Lætitia), Cherrier, T. (Thomas), Thomas Cherrier, Redel, L. (Laetitia), Christian Schwartz, Marban, C. (Céline), Schwartz, Christian, Redel, Laetitia, Rohr, Olivier, Cherrier, Thomas, Marban, Celine, Aunis, Dominique, Dominique Aunis, Marban-doran, C. (Celine), Redel, Lætitia, Céline Marban, Lætitia Redel, Marban-Doran, Celine, Le Douce, V. (Valentin)   +25 more
core   +5 more sources

Modulation of IRF7-driven transcription as a strategy to control HIV-1 latency [PDF]

Frontiers in Immunology
BackgroundThe persistence of latent HIV-1 reservoirs remains a major barrier to achieving a cure for HIV. While latency-reversing agents (LRAs) have been extensively studied, latency-promoting agents (LPAs) offer a complementary strategy to silence viral
Ifeanyi Jude Ezeonwumelu, Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Edurne Garcia-Vidal, Eudald Felip, Eudald Felip, Eudald Felip, Sara Cabrero-de las Heras, Sara Cabrero-de las Heras, Bonaventura Clotet, Bonaventura Clotet, Roger Badia, Roger Badia, Ester Ballana, Ester Ballana, Ester Ballana, Eva Riveira-Muñoz, Eva Riveira-Muñoz, Maria Nevot, Maria Nevot   +19 more
doaj   +2 more sources

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells [PDF]

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +2 more sources

Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation [PDF]

Journal of Virology
HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a prerequisite for
Cancan Chen, Zhihan Zhong, Wanying Zhang, Baijin Xia, Liyang Wu, Liting Liang, Yiwen Zhang, Hui Zhang, Xu Zhang, Ting Pan, Linghua Li, Bingfeng Liu   +11 more
doaj   +2 more sources

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency [PDF]

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi   +14 more
doaj   +2 more sources

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +2 more sources