Results 11 to 20 of about 66,330 (250)

NSC95397 Is a Novel HIV-1 Latency-Reversing Agent. [PDF]

Viruses, 2023
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has led to the discovery of many latency-reversing agents (LRAs) that have furthered our understanding ...
Nichols Doyle R, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI.   +5 more
europepmc   +10 more sources

An Integrated Overview of HIV-1 Latency [PDF]

Cell, 2013
Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs.
Ruelas, Debbie S, Greene, Warner C
openaire   +6 more sources

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells [PDF]

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +2 more sources

Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation [PDF]

Journal of Virology
HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a prerequisite for
Cancan Chen, Zhihan Zhong, Wanying Zhang, Baijin Xia, Liyang Wu, Liting Liang, Yiwen Zhang, Hui Zhang, Xu Zhang, Ting Pan, Linghua Li, Bingfeng Liu   +11 more
doaj   +2 more sources

Roles of microRNAs in HIV-1 Replication and Latency [PDF]

MicroRNA, 2016
MicroRNAs (miRNAs) are non-coding RNA molecules, with sequence length of 19-24 nucleotides, which can induce mRNA degradation and regulate protein translation repression. Recently plenty of reports showed that miRNAs increase or decrease in the serum (circulating miRNAs) and in PBMC of Human immunodeficiency virus type 1 (HIV-1) infected individuals to
Sun, Binlian, Yang, Rongge, MALLARDO, MASSIMO   +2 more
openaire   +4 more sources

HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
HIV-1 infection remains non-curative due to the latent reservoir, primarily a small pool of resting memory CD4+ T cells bearing replication-competent provirus.
Raquel Crespo, Shringar Rao, Tokameh Mahmoudi, Tokameh Mahmoudi, Tokameh Mahmoudi   +4 more
doaj   +3 more sources

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency [PDF]

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi   +14 more
doaj   +2 more sources

Hypoxic microenvironment shapes HIV-1 replication and latency [PDF]

Communications Biology, 2020
AbstractViral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary lymphoid tissues exist in a low-oxygen or hypoxic environment in vivo. However, the majority
Zhuang, X, Pedroza-Pacheco, I, Nawroth, I, Kliszczak, AE, Magri, A, Paes, W, Rubio, CO, Yang, H, Ashcroft, M, Mole, D, Balfe, P, Borrow, P, McKeating, JA   +12 more
openaire   +7 more sources

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +2 more sources

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3 [PDF]

Cell Communication and Signaling
Background Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, and the main obstacle is the existence of viral reservoirs. However, we currently do not fully understand the molecular mechanisms by which HIV-1 latency is established and ...
Xinyi Yang, Yuqi Zhu, Xiaying Zhao, Jingna Xun, Xingyu Wang, Yipeng Cheng, Su Xiong, Xingwen Yu, Suixiang Li, Danqing Wang, Zhiliang Hu, Yinzhong Shen, Shibo Jiang, Hongzhou Lu, Gang Wang, Huanzhang Zhu   +15 more
doaj   +2 more sources