Results 11 to 20 of about 32,488 (258)

[Viral latency of HIV-1]. [PDF]

Virologie (Montrouge, France), 2019
info:eu-repo/semantics ...
Bouchat, Sophie, Van Lint, Carine
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HIV Latency TORn Down [PDF]

Cell Host & Microbe, 2016
Combination therapy for HIV infection is effective at controlling disease but fails to eradicate the virus because a persistent reservoir of cells harbors latent HIV DNA. In this issue of Cell Host & Microbe, Besnard et al. (2016) show that the mTOR kinase is essential to reactivate HIV from latency.
GIACCA, MAURO
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A Hardwired HIV Latency Program [PDF]

Cell, 2015
Biological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with latency simply an epiphenomenon of infected cells transitioning from an activated to resting state.
Razooky, Brandon S, Pai, Anand, Aull, Katherine, Rouzine, Igor M, Weinberger, Leor S   +4 more
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MicroRNA-155 Reinforces HIV Latency [PDF]

Journal of Biological Chemistry, 2015
The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death due to a viral cytopathic effect, 2) cell death due to immune clearance, or 3) a retreat into latency ...
Ruelas, Debbie S, Chan, Jonathan K, Oh, Eugene, Heidersbach, Amy J, Hebbeler, Andrew M, Chavez, Leonard, Verdin, Eric, Rape, Michael, Greene, Warner C   +8 more
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HIV reservoirs and latency models [PDF]

Virology, 2011
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J., Agosto, Luis, Graf, Erin H., O'Doherty, Una   +3 more
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Primary cell models of HIV latency [PDF]

Current Opinion in HIV and AIDS, 2011
To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.It has been challenging to develop a primary cell model of HIV latency that can authentically recapitulate the quiescent features of resting CD4+ T cells ...
楊宏志, YANG, HUNG-CHIH
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An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review [PDF]

HIV/AIDS: Research and Palliative Care, 2023
Peter W Ramirez,1 Christina Pantoja,1 Nadejda Beliakova-Bethell2,3 1Department of Biological Sciences, California State University, Long Beach, CA, USA; 2VA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, CA, USA ...
Ramirez PW, Pantoja C, Beliakova-Bethell N   +2 more
doaj   +1 more source

[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency]. [PDF]

Medecine sciences : M/S, 2010
L’introduction de la multithérapie active en 1996 s’est avérée très efficace et avait entretenu l’espoir d’éradiquer le virus du Sida. Malheureusement, des obstacles à son éradication sont rapidement apparus, notamment la mise en évidence du phénomène de latence virale dans les principales cellules cibles du virus, dont les lymphocytes T CD4+ et les ...
Schwartz, Christian, Le Douce, Valentin, Cherrier, Thomas, Redel, Laetitia, Marban-Doran, Celine, Aunis, Dominique, Rohr, Olivier   +6 more
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HIV Latency in the Humanized BLT Mouse [PDF]

Journal of Virology, 2012
ABSTRACT Even after extended treatment with powerful antiretroviral drugs, HIV is not completely eliminated from infected individuals. Latently infected CD4 + T cells constitute one reservoir of replication-competent HIV that needs to be eliminated to completely purge virus ...
Matthew D, Marsden, Michael, Kovochich, Nuttee, Suree, Saki, Shimizu, Roshni, Mehta, Ruth, Cortado, Gregory, Bristol, Dong Sung, An, Jerome A, Zack   +8 more
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The Cultured TCM Model of HIV Latency [PDF]

, 2022
Models to study HIV latency have improved our understanding of the mechanisms involved in this process and have helped in the discovery and development of therapeutic strategies to eradicate HIV. Primary cell models are based on the in vitro generation of latently infected cells using CD4T cells isolated from blood, lymph nodes or other lymphoid organs.
Alberto Bosque, Bosque, Alberto
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