Results 11 to 20 of about 32,363 (272)
The role of Tat in HIV latency and reactivation [PDF]
Frontiers in ImmunologyHIV persists during therapy due the existence of a latently infected reservoir in which viral gene expression is silenced. This reservoir thus represents the primary barrier to a cure for HIV.
David M. Margolis, Edward P. Browne
doaj +8 more sources
β-catenin regulates HIV latency and modulates HIV reactivation. [PDF]
PLoS Pathogens, 2022 Latency is the main obstacle towards an HIV cure, with cure strategies aiming to either elicit or prevent viral reactivation. While these strategies have shown promise, they have only succeeded in modulating latency in a fraction of the latent HIV ...
Hannah J Barbian +6 more
doaj +3 more sources
The mTOR Complex Controls HIV Latency [PDF]
Cell Host and Microbe, 2016 A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on antiretroviral therapy, posing a barrier to HIV eradication.
Emilie Besnard +2 more
exaly +7 more sources
HIV-1 Latency in Monocytes/Macrophages [PDF]
Viruses, 2014 Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been ...
Wasim Abbas, Georges Herbein
exaly +5 more sources
Diverse effects of interferon alpha on the establishment and reversal of HIV latency.
PLoS Pathogens, 2020 HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells.
Renée M Van der Sluis +16 more
doaj +2 more sources
[Viral latency of HIV-1] [PDF]
Virologie (Montrouge, France), 2019 Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs.
Van Lint, Carine, Bouchat, Sophie
core +3 more sources
Cell Host & Microbe, 2016 Combination therapy for HIV infection is effective at controlling disease but fails to eradicate the virus because a persistent reservoir of cells harbors latent HIV DNA. In this issue of Cell Host & Microbe, Besnard et al.
GIACCA, MAURO
core +4 more sources
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation [PDF]
Frontiers in Immunology, 2022 The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute ...
Ifeanyi Jude Ezeonwumelu +22 more
doaj +2 more sources
HIV-1 Latency and Latency Reversal: Does Subtype Matter?
Viruses, 2019 Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide.
Indra Sarabia, Alberto Bosque
exaly +2 more sources
Cell Reports, 2018 Summary: A detailed understanding of the mechanisms that establish or maintain the latent reservoir of HIV will guide approaches to eliminate persistent infection. We used a cell line and primary cell models of HIV latency to investigate viral RNA (vRNA)
Todd Bradley +4 more
doaj +3 more sources