Results 11 to 20 of about 799,404 (198)
The role of Tat in HIV latency and reactivation [PDF]
Frontiers in ImmunologyHIV persists during therapy due the existence of a latently infected reservoir in which viral gene expression is silenced. This reservoir thus represents the primary barrier to a cure for HIV.
David M. Margolis, Edward P. Browne
doaj +4 more sources
β-catenin regulates HIV latency and modulates HIV reactivation
PLoS Pathogens, 2022 Latency is the main obstacle towards an HIV cure, with cure strategies aiming to either elicit or prevent viral reactivation. While these strategies have shown promise, they have only succeeded in modulating latency in a fraction of the latent HIV ...
Hannah J Barbian +2 more
exaly +2 more sources
A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency [PDF]
mBioAntiretroviral therapy suppresses HIV replication but fails to eliminate the virus due to the persistence of a transcriptionally silent reservoir, which remains the primary barrier to a cure.
Samuel D. Burgos +6 more
doaj +2 more sources
[Viral latency of HIV-1] [PDF]
Virologie (Montrouge, France), 2019 Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs.
Van Lint, Carine, Bouchat, Sophie
core +3 more sources
PKC inhibitors reveal PKC isoforms involved in HIV latency reversal and immunomodulation [PDF]
Journal of VirologyThe reservoir of persistently latently infected cells is a major barrier to a cure for HIV infection. Protein kinase C (PKC) modulators can reverse HIV latency and could thus be useful “Kick” components in “Kick and Kill” approaches to a cure.
Thomas D. Zaikos +10 more
doaj +2 more sources
Diverse effects of interferon alpha on the establishment and reversal of HIV latency
PLoS Pathogens, 2020 HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells.
Rachel Pascoe +2 more
exaly +2 more sources
Cell Host & Microbe, 2016 Combination therapy for HIV infection is effective at controlling disease but fails to eradicate the virus because a persistent reservoir of cells harbors latent HIV DNA. In this issue of Cell Host & Microbe, Besnard et al.
GIACCA, MAURO
core +4 more sources
Cell Reports, 2018 Summary: A detailed understanding of the mechanisms that establish or maintain the latent reservoir of HIV will guide approaches to eliminate persistent infection. We used a cell line and primary cell models of HIV latency to investigate viral RNA (vRNA)
Guido Ferrari, Edward P Browne
exaly +3 more sources
A Hardwired HIV Latency Program [PDF]
Cell, 2015 SummaryBiological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with ...
Rouzine, Igor +14 more
core +6 more sources
Primary Cell Models of Hiv Latency
Current Opinion in HIV and AIDS, 2012 Purpose of review: To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.
楊宏志, YANG, HUNG-CHIH
core +3 more sources