Results 71 to 80 of about 32,363 (272)

Mathematical Models of HIV Latency [PDF]

, 2017
Viral latency is a major barrier to curing HIV infection with antiretroviral therapy, and consequently, for eliminating the disease globally. The establishment, maintenance, and potential clearance of latent infection are complex dynamic processes and can be best understood and described with the help of mathematical models.
openaire   +2 more sources

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Delineating gender/sex‐related studies through bibliometric analysis

Journal of the Association for Information Science and Technology, EarlyView.
Abstract The multidisciplinary and socially grounded nature of Women's/Gender/Feminist Studies poses unique challenges for bibliometric analysis, as it extends beyond conventional disciplinary boundaries. This paper makes three key contributions: (1) We propose a novel retrieval method for constructing a corpus of scholarly documents in research areas ...
Natsumi S. Shokida, Diego Kozlowski, Vincent Larivière   +2 more
wiley   +1 more source

Mechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency

Biomolecules, 2023
The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent
Benni Vargas, James Boslett, Nathan Yates, Nicolas Sluis-Cremer   +3 more
doaj   +1 more source

Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
wiley   +1 more source

HTLV-1 Tax activates HIV-1 transcription in latency models. [PDF]

, 2017
HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription.
Amilcar Tanuri, Leal, Fabio E, Tanuri, Amilcar, Nixon, Douglas F, Aguiar, Renato Santana, José, Diego Pandeló, Diego Pandeló José, Douglas F. Nixon, Fabio E. Leal, Victor Emmanuel Viana Geddes, Geddes, Victor Emmanuel Viana, Renato Santana de Aguiar   +11 more
core   +1 more source

Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal.

PLoS ONE, 2019
The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency ...
Wim Trypsteen, Cory H White, Amey Mukim, Celsa A Spina, Ward De Spiegelaere, Steve Lefever, Vicente Planelles, Alberto Bosque, Christopher H Woelk, Linos Vandekerckhove, Nadejda Beliakova-Bethell   +10 more
doaj   +1 more source

Combination immune checkpoint blockade to reverse HIV latency

, 2020
In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4+ T cells expressing multiple immune checkpoint (IC) molecules, including programmed death (PD)-1, T cell Ig and mucin ...
Sékaly, RP, Pascoe, RD, Evans, VA, Zerbato, JM, Chomont, N, Kumar, NA, Van Der Sluis, RM, Anderson, JL, Lewin, SR, Dantanarayana, AI, Fromentin, R, Cameron, PU   +11 more
core   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

An Integrated Overview of HIV-1 Latency [PDF]

Cell, 2013
Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs.
Ruelas, Debbie S, Greene, Warner C
openaire   +4 more sources