Results 91 to 100 of about 32,363 (272)

Latency: the hidden HIV-1 challenge [PDF]

Retrovirology, 2006
AbstractEradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection upon interruption of the treatment.
openaire   +3 more sources

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

Cell Reports, 2019
Summary: Latent proviruses persist in central (TCM), transitional (TTM), and effector (TEM) memory cells. We measured the levels of cellular factors involved in HIV gene expression in these subsets.
Marion Pardons, Rémi Fromentin, Amélie Pagliuzza, Jean-Pierre Routy, Nicolas Chomont   +4 more
doaj   +1 more source

Transient-mediated fate determination in a transcriptional circuit of HIV

, 2007
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Michael Simpson, Roy D. Dar, Leor Weinberger   +2 more
core  

HIV-1 latency in proliferating T cells [PDF]

, 2013
In this thesis we focus on the ability of HIV-1 to establish a latent provirus in proliferating T cells and on how the silent provirus can be activated from latency. HIV-1 latency is a major barrier towards virus eradication from the infected individual.
van der Sluis, R.M., van der Sluis, Renée M.   +1 more
core  

Innate Immune Regulation in HIV Latency

, 2021
Thesis (Ph.D.)--University of Washington, 2021Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV-1 infection within CD4+ T cells.
Olson, Rebecca
core  

CpG methylation controls reactivation of HIV from latency. [PDF]

, 2009
DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune responses and antiretroviral drugs.
Gondois-Rey, Françoise, Guiguen, Allan, Katerina Trejbalova, Van Lint, Carine, Hejnar, Jiri, Hirsch Ivan, Allan Guiguen, Daniel Olive, Ivan Hirsch, Guiguen Allan, Gondois-Rey Françoise, Halfon Philippe, Blazkova Jana, Blazkova, Jana, Trejbalova Katerina, Verdin, Eric, Philibert Patrick, Patrick Philibert, Carine Van Lint, Halfon, Philippe, Philippe Halfon, Verdin Eric, Jiri Hejnar, Hejnar Jiri, Trejbalova, Katerina, Olive Daniel, Van Lint Carine, Françoise Gondois-Rey, Eric Verdin, Philibert, Patrick, Hirsch, Ivan, Olive, Daniel, Jana Blazkova   +32 more
core   +1 more source

Diagnostic Performance of Comprehensive Point‐of‐Care Ultrasound for Pediatric Tuberculosis in Spain: A Prospective Observational Study

Journal of Clinical Ultrasound, EarlyView.
In children with presumptive tuberculosis, comprehensive point‐of‐care (cPOCUS) identified key thoracic abnormalities with high specificity and excellent inter‐reader reliability. Although diagnostic sensitivity was modest and examinations often incomplete, cPOCUS shows promise as a complementary, radiation‐free imaging tool.
Isabelle Munyangaju, Antoni Noguera‐Julian, Aleix Soler‐Garcia, Antoni Soriano‐Arandes, José Miguel Escudero Fernández, Maria Espiau, Begoña Santiago Garcia, Alicia Hernanz‐Lobo, Ángel M. Lancharro Zapata, Enrique Ladera, Angela Manzanares, Daniel Blazquez, Elisa Aguirre Pascual, Isabelle Thierry‐Chef, Danilo Buonsenso, Xavier Serres‐Créixams, Quique Bassat, Elisa Lopez‐Varela   +17 more
wiley   +1 more source

HIV latency: present knowledge and future directions

, 2006
International audienceCurrent therapies do not eradicate HIV from infected patients. Indeed, HIV hides in a latent form insensitive to these therapies. Thus, one priority is to eliminate these latent reservoirs.
Peterlin, B Matija, Lenasi, Tina, Contreras, Xavier   +2 more
core   +1 more source

Micro RNA targets in HIV latency - insights into novel layers of latency control. [PDF]

, 2020
Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus.
Macarthur, Ben D, Moesker, Bastiaan, Macarthur, Ben D., Woo, Jeongmin, Spina, Celsa, Spina, Celsa A., Bosque, Alberto, Beliakova-Bethell, Nadejda, White, Cory H, Woelk, Christopher H, Heinson, Ashley I, Mukim, Amey, White, Cory H., Spina, Celsa A, Heinson, Ashley I., Woelk, Christopher H.   +15 more
core   +1 more source

Mental health measures among adolescents in 12 low‐ and middle‐income countries: Measurement invariance and cross‐sectional analyses of Disrupting Harm survey data

JCPP Advances, EarlyView.
Abstract Background Nationally representative mental health data in adolescents from low‐ and middle‐income countries (LMICs) are scarce. This study aimed to examine mental health and wellbeing indicators amongst adolescents in 12 LMICs across Eastern and Southern Africa and Southeast Asia. Methods We conducted a secondary analysis of data involving 12,
Ariadna Albajara Sáenz, Sebastian Kurten, Jennifer Saxton, Daniel Kardefelt‐Winther, Tamsin Ford, Amy Orben, Simon R. White   +6 more
wiley   +1 more source