Results 91 to 100 of about 32,488 (258)

Generation of HIV Latency in Humanized BLT Mice [PDF]

Journal of Virology, 2012
ABSTRACT Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4 + T ...
Denton, Paul W., Olesen, Rikke; id_orcid 0000-0002-5157-080X, Choudhary, Shailesh K, Archin, Nancy M, Wahl, Angela, Swanson, Michael D, Chateau, Morgan, Nochi, Tomonori, Krisko, John F, Spagnuolo, Rae Ann, Margolis, David M, Garcia, J Victor   +11 more
openaire   +3 more sources

Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress

EMBO Molecular Medicine, 2021
HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV‐1 infection, but its role in the ...
Iart Luca Shytaj, Francesco Andrea Procopio, Mohammad Tarek, Irene Carlon‐Andres, Hsin‐Yao Tang, Aaron R Goldman, MohamedHusen Munshi, Virender Kumar Pal, Mattia Forcato, Sheetal Sreeram, Konstantin Leskov, Fengchun Ye, Bojana Lucic, Nicolly Cruz, Lishomwa C Ndhlovu, Silvio Bicciato, Sergi Padilla‐Parra, Ricardo Sobhie Diaz, Amit Singh, Marina Lusic, Jonathan Karn, David Alvarez‐Carbonell, Andrea Savarino   +22 more
doaj   +1 more source

Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi, Nishant Pandey, Sushan Ghimire, Avilasha Shah, Anurag Tiwari, Salina Subedi, Deepika Neupane   +6 more
wiley   +1 more source

Latency: the hidden HIV-1 challenge [PDF]

Retrovirology, 2006
AbstractEradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection upon interruption of the treatment.
openaire   +3 more sources

HIV-1 latency in proliferating T cells [PDF]

, 2013
In this thesis we focus on the ability of HIV-1 to establish a latent provirus in proliferating T cells and on how the silent provirus can be activated from latency. HIV-1 latency is a major barrier towards virus eradication from the infected individual.
van der Sluis, R.M., van der Sluis, Renée M.   +1 more
core  

CpG methylation controls reactivation of HIV from latency. [PDF]

, 2009
DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune responses and antiretroviral drugs.
Gondois-Rey, Françoise, Guiguen, Allan, Katerina Trejbalova, Van Lint, Carine, Hejnar, Jiri, Hirsch Ivan, Allan Guiguen, Daniel Olive, Ivan Hirsch, Guiguen Allan, Gondois-Rey Françoise, Halfon Philippe, Blazkova Jana, Blazkova, Jana, Trejbalova Katerina, Verdin, Eric, Philibert Patrick, Patrick Philibert, Carine Van Lint, Halfon, Philippe, Philippe Halfon, Verdin Eric, Jiri Hejnar, Hejnar Jiri, Trejbalova, Katerina, Olive Daniel, Van Lint Carine, Françoise Gondois-Rey, Eric Verdin, Philibert, Patrick, Hirsch, Ivan, Olive, Daniel, Jana Blazkova   +32 more
core   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Clinical Epigenetics, 2018
HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan, Mazhar Iqbal, Muhammad Tariq, Shahid M. Baig, Wasim Abbas   +4 more
doaj   +1 more source

Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients [PDF]

, 2003
Forty-seven bronchoalveolar lavage fluid samples from 16 human immunodeficiency virus (HIV)-infected patients were used to test the latency model of Pneumocystis infection in the human host.
Denis, CM, Wakefield, AE, Ambrose, HE, Lindley, AR, Miller, RF   +4 more
core  

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency [PDF]

, 2011
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral latency established within the host genome remains largely ...
Margolis, David M., Choudhary, Shailesh K., David M. Margolis, Shailesh K. Choudhary   +3 more
core   +2 more sources