Results 101 to 110 of about 32,363 (272)

Nanoparticle delivery of molecular agents to tackle HIV latency [PDF]

, 2022
Antiretroviral therapy (ART) effectively suppresses HIV replication in people living with HIV (PLWH), but treatment is lifelong. The persistence of long-lived, latently infected resting CD4+T cells is a significant challenge in achieving a cure for HIV ...
Ali, Abdalla Abbas Jafer
core   +1 more source

Associations between health care access and posttraumatic stress disorder symptoms among rural and urban lesbian, gay, bisexual, transgender, and queer adults

Journal of Traumatic Stress, EarlyView.
Abstract Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) individuals experience elevated rates of trauma exposure, minority stress, and posttraumatic stress disorder (PTSD). Yet, research examining how geographic location and LGBTQ+ identity shape PTSD outcomes is scant, particularly studies considering structural facilitators and barriers ...
Emily A. Kenyon, Michelle A. Stage, Reina Kiefer, Mollie A. Ruben, Nicholas A. Livingston, Danielle S. Berke, Jillian C. Shipherd   +6 more
wiley   +1 more source

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi   +14 more
doaj   +1 more source

The UK register of HIV seroconverters: Methods and analytical issues

, 1996
A Register of HIV-infected persons who have had a negative antibody test within 3 years of their first antibody positive test (seroconverters) is being set up in the UK to monitor the distribution of times from HIV seroconversion to AIDS (the incubation ...
Babiker, A, Phillips, AN, Porter, K, Mortimer, PP, Darbyshire, JH, Hawkins, DA, Weber, J, Wellsteed, S, Brettle, RP, Carne, C, Goldberg, D, Johnson, MA, Gilson, RJC, Jeffries, D, Evans, BG, Beral, V, Johnson, AM, McMichael, AJ, Pozniak, A   +18 more
core  

No Evidence for Association of beta-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS

Common single-nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load set point).
Mclaren, Paul J., Lakhi, Shabir, Hollox, Edward J., Abujaber, Razan, Gilmour, Jill, Allen, Susan, Fellay, Jacques, Shea, Patrick R.   +7 more
core   +1 more source

HIV Latency: Stochastic across Multiple Scales

, 2019
Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic ...
Weinberger, Leor S., Hansen, Maike M. K., Martin, Benjamin   +2 more
core   +1 more source

The dialectics of trauma and political conscientization: A psychosocial study of activism for supporting sexual and gender minoritized communities in Brazil

Journal of Traumatic Stress, EarlyView.
Abstract This qualitative study examined the dialectical association between psychosocial trauma and political conscientization in the lives of activists advocating for persons with marginalized sexual orientations and gender identities (2SLGBTQIA+) in São José dos Campos, Brazil.
Gab C. Siqueira, Luisa F. Velásquez Vallejo, Antonio Euzebios Filho   +2 more
wiley   +1 more source

Intersectional discrimination, identity conflict, and posttraumatic stress symptoms among bisexual+ people of color

Journal of Traumatic Stress, EarlyView.
Abstract Bisexual and other multigender‐attracted (e.g., pansexual, queer) people (bi+) report disproportionately high posttraumatic stress symptoms (PTSS) linked to a high frequency of discrimination and general trauma exposure. Bi+ people of color (POC) may be particularly vulnerable to PTSS given exposure to intersectional discrimination (e.g ...
Roberto Rentería, Jacquie Mitzner, Diana Kaziyev, Nicholas A. Livingston, Emily Bettin, Brian A. Feinstein   +5 more
wiley   +1 more source

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells

iScience
Summary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj   +1 more source

Deep latency: A new insight into a functional HIV cure

EBioMedicine, 2019
Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While antiretroviral therapy is effective in controlling viral replication, it cannot eliminate latent HIV reservoirs in patients.
Maher M. Elsheikh, Yuyang Tang, Dajiang Li, Guochun Jiang   +3 more
doaj   +1 more source