Results 101 to 110 of about 32,488 (258)

Micro RNA targets in HIV latency - insights into novel layers of latency control. [PDF]

, 2020
Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus.
Macarthur, Ben D, Moesker, Bastiaan, Macarthur, Ben D., Woo, Jeongmin, Spina, Celsa, Spina, Celsa A., Bosque, Alberto, Beliakova-Bethell, Nadejda, White, Cory H, Woelk, Christopher H, Heinson, Ashley I, Mukim, Amey, White, Cory H., Spina, Celsa A, Heinson, Ashley I., Woelk, Christopher H.   +15 more
core   +1 more source

Nanoparticle delivery of molecular agents to tackle HIV latency [PDF]

, 2022
Antiretroviral therapy (ART) effectively suppresses HIV replication in people living with HIV (PLWH), but treatment is lifelong. The persistence of long-lived, latently infected resting CD4+T cells is a significant challenge in achieving a cure for HIV ...
Ali, Abdalla Abbas Jafer
core   +2 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Chromatin regulation and the histone code in HIV latency [PDF]

, 2017
The formation of a latent reservoir of Human Immunodeficiency Virus (HIV†) infection hidden from immune clearance remains a significant obstacle to approaches to eradicate HIV infection.
Turner, A.-M.W., Margolis, D.M.
core   +2 more sources

Hypoxic microenvironment shapes HIV-1 replication and latency [PDF]

, 2020
: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen.
Ashcroft, Margaret, Balfe, Peter, Paes, Wayne, Rubio, Claudia Orbegozo, Yang, Hongbing, Pedroza-Pacheco, Isabela, Kliszczak, Anna E, Nawroth, Isabel, Magri, Andrea, Zhuang, Xiaodong, Borrow, Persephone, Mole, David, McKeating, Jane A   +12 more
core   +2 more sources

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi   +14 more
doaj   +1 more source

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

Cell Reports, 2019
Summary: Latent proviruses persist in central (TCM), transitional (TTM), and effector (TEM) memory cells. We measured the levels of cellular factors involved in HIV gene expression in these subsets.
Marion Pardons, Rémi Fromentin, Amélie Pagliuzza, Jean-Pierre Routy, Nicolas Chomont   +4 more
doaj   +1 more source

Characterizing Combined Central and Peripheral Demyelination—Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Combined central and peripheral demyelination (CCPD) is a rare dysimmune disorder sharing features with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Direct comparisons of central and peripheral diagnostic findings across these entities remain limited. We, therefore, performed a
N. Dubuisson, A. Kassab, P. Y. K. Van den Bergh, A. F. J. E. Vrancken, W. L. van der Pol, L. H. van den Berg, H. S. Goedee   +6 more
wiley   +1 more source

Optimal Control Analysis of Vertically Transmitted Infectious Diseases With Saturated Incidence and Nonlinear Treatment

Optimal Control Applications and Methods, EarlyView.
Schematic representation of the proposed disease transmission model incorporating vertical transmission, saturated incidence, and nonlinear treatment. The study combines theoretical analysis, bifurcation and stability investigations, and optimal control techniques to evaluate prevention and treatment interventions.
Oludolapo A. Olanrewaju, Sulaimon F. Abimbade   +1 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source