Results 101 to 110 of about 799,404 (198)

BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells

Journal of Virology
HIV cure strategies that aim to induce viral reactivation for immune clearance leverage latency reversal agents to modulate host pathways which directly or indirectly facilitate viral reactivation.
Anne-Marie W. Turner, Frances M. Bashore, Shane D. Falcinelli, Joshua A. Fox, Alana L. Keller, Anthony D. Fenton, Renee F. Geyer, Brigitte Allard, Jennifer L. Kirchherr, Nancie M. Archin, Lindsey I. James, David M. Margolis   +11 more
doaj   +1 more source

No Evidence for Association of beta-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS

Common single-nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load set point).
Mclaren, Paul J., Lakhi, Shabir, Hollox, Edward J., Abujaber, Razan, Gilmour, Jill, Allen, Susan, Fellay, Jacques, Shea, Patrick R.   +7 more
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HIV-1 latency: From acquaintance to confidant

Journal of Virus Eradication
Antiretroviral therapy (ART) has transformed HIV from a fatal disease into manageable circumstance. However, the HIV reservoirs remain a main barrier to complete cure.
Chenbo Yang, Ling Tong, Jing Xue
doaj   +1 more source

HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4+ T cells.

PLoS Pathogens
Antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents HIV transmission. However, ART does not cure HIV infection because of a persistent, latent viral reservoir in long-lived cells such as central ...
Catherine A Lewis, David M Margolis, Edward P Browne   +2 more
doaj   +1 more source

HIV and and transgender people

HIV Diagnoses in the US, 2009-20142,351 TRANSGENDER PEOPLE RECEIVED AN HIV DIAGNOSIS. OF THESE:\u2022 84% WERE TRANSGENDER WOMEN\u2022 15% WERE TRANSGENDER MEN*\u2022 ABOUT HALF LIVED IN THE SOUTHcdc-hiv-transgender-factsheet ...

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HIV and women

At the end of 2010, one in four people living with HIV in the United States were women. Black/African American and Hispanic/ Latino women continue to be disproportionately affected by HIV, compared with women of other races/ethnicities.

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The relationship between HIV seroconversion illness, HIV test interval and time to AIDS in a seroconverter cohort. [PDF]

, 2003
Seroconversion illness is known to be associated with more rapid HIV disease progression. However, symptoms are often subjective and prone to recall bias.
UK Register of HIV Seroconverters, UK, Gillett, J, Tyrer, F, Porter, K, Walker, AS   +4 more
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PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
doaj   +1 more source

HIV and injection drug use [PDF]

Fast facts:\ue2\u20ac\ua2 HIV infections due to injection drug use have declined, but injecting drugs remains a significant risk.\ue2\u20ac\ua2 Sharing syringes is a direct route of HIV transmission.\ue2\u20ac\ua2 In one study, two out of five people who

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HIV treatment can prevent sexual transmission [PDF]

People with HIV should take medicine to treat HIV as soon as possible to\u2022 Improve their own health, and\u2022 Prevent transmitting HIV to other people.cdc-hiv-tasp-101 ...

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