Results 121 to 130 of about 32,488 (258)

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.

PLoS Pathogens, 2019
The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are ...
Zichong Li, Jun Wu, Leonard Chavez, Rebecca Hoh, Steven G Deeks, Satish K Pillai, Qiang Zhou   +6 more
doaj   +1 more source

RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

Retrovirology, 2018
Background Current antiretroviral therapy is effective in controlling HIV-1 infection. However, cessation of therapy is associated with rapid return of viremia from the viral reservoir.
Catalina Méndez, Scott Ledger, Kathy Petoumenos, Chantelle Ahlenstiel, Anthony D. Kelleher   +4 more
doaj   +1 more source

Analysing Higher Education Institutions' Role in Sustainable Development Goals: A Systematic Literature Review Analysis and Future Directions

Business Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT This paper examines the current state of the art regarding the contribution of Higher Education Institutions (HEIs) to the achievement of the Sustainable Development Goals (SDGs). We conducted a Systematic Literature Review Analysis (SLRA), which integrates a traditional Systematic Literature Review (SLR) with Bibliographic Analysis (BA), on a
Pasquale Latella, Stefania Veltri
wiley   +1 more source

Untangling CSR Decoupling: Board Attributes Effects and the Unexplored Moderating Role of Board Gender Diversity

Business Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT This study investigates the phenomenon of corporate social responsibility (CSR) decoupling, wherein firms' CSR disclosures diverge from their actual CSR performance, often resulting in misleading portrayals of environmental and social commitments commonly associated with greenwashing.
María Consuelo Pucheta‐Martínez, Isabel Gallego‐Álvarez, Inmaculada Bel‐Oms   +2 more
wiley   +1 more source

Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta‐analysis

BJU International, EarlyView.
Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa, Ali Amiri, Sanchit Kaushal, Emma Wilson, Isabelle Tan, Robert J. Hamilton   +5 more
wiley   +1 more source

SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin

mBio, 2018
The postintegrational latency of HIV-1 is characterized by reversible silencing of long terminal repeat (LTR)-driven transcription of the HIV genome. It is known that the formation of repressive chromatin at the 5′-LTR of HIV-1 proviral DNA impedes viral
Wei-Wei Sun, Shi Jiao, Li Sun, Zhaocai Zhou, Xia Jin, Jian-Hua Wang   +5 more
doaj   +1 more source

Cumulative effect of multiple health and social factors on adolescent mental well‐being: a cross‐sectional study in Catalonia

Child and Adolescent Mental Health, EarlyView.
Background While numerous studies have explored factors contributing to poor mental health, few have examined the combined influence of multiple health and social factors and their cumulative effect. This study specifically aimed to analyze the cumulative effect of multiple health and social factors associated with poor mental well‐being in school‐aged
Marina Robles‐Muñoz, Marina Bosque‐Prous, Cinta Folch, Helena González‐Casals, Gemma Drou‐Roget, Cristina Torrado‐Cortés, Carles Muntaner, Albert Espelt   +7 more
wiley   +1 more source

Modulation of IRF7-driven transcription as a strategy to control HIV-1 latency

Frontiers in Immunology
BackgroundThe persistence of latent HIV-1 reservoirs remains a major barrier to achieving a cure for HIV. While latency-reversing agents (LRAs) have been extensively studied, latency-promoting agents (LPAs) offer a complementary strategy to silence viral
Ifeanyi Jude Ezeonwumelu, Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Edurne Garcia-Vidal, Eudald Felip, Eudald Felip, Eudald Felip, Sara Cabrero-de las Heras, Sara Cabrero-de las Heras, Bonaventura Clotet, Bonaventura Clotet, Roger Badia, Roger Badia, Ester Ballana, Ester Ballana, Ester Ballana, Eva Riveira-Muñoz, Eva Riveira-Muñoz, Maria Nevot, Maria Nevot   +19 more
doaj   +1 more source

European Society of Contact Dermatitis Guideline for Diagnostic Patch Testing—Recommendations on Best Practice (Update 2026)

Contact Dermatitis, EarlyView.
ABSTRACT The present guideline updates the initial ESCD patch testing guideline, summarizing all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed‐type hypersensitivity skin and mucosal conditions. Sections with brief descriptions
Wolfgang Uter, Olivier Aerts, Tove Agner, Richard Brans, Magnus Bruze, Alicia Cannavó, Marie‐Noёlle Crépy, Ana M. Giménez‐Arnau, Margarida Gonçalo, An Goossens, Swen M. John, Carola Lidén, Suzana Ljubojević Hadžavdić, Vera Mahler, Mihaly Matura, Esen Özkaya, Maria Pesonen, Nadia Raison‐Peyron, Thomas Rustemeyer, Radoslaw Spiewak, Luca Stingeni, Ian R. White, S. Mark Wilkinson, Jeanne Duus Johansen   +23 more
wiley   +1 more source

Bioinformatics and HIV Latency [PDF]

, 2021
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the ...
Golumbeanu, Monica, Telenti, Amalio, di Iulio, Julia, Ciuffi, Angela, Mohammadi, Pejman   +4 more
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