Results 141 to 150 of about 32,363 (272)

BRD9 functions as an HIV-1 latency regulatory factor [PDF]

A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs ...
Zhou, Runhong, Chen, Zhiwei, Huang, Huarong, Yim, Lok-Yan, Zhao, Meiqing, Lau, Thomas Tsz-Kan, Chan, Jasper Fuk-Woo, Cheng, Alfred Sze-Lok, Huang, Xiner, Yuen, Kwok-Yung, Chu, Hin, Dai, Jie, Luk, Tsz-Yat, Lui, Grace Chung-Yan, Mo, Yufei   +14 more
core   +1 more source

Sexually Transmitted Infection Prevalence and Determinants Among Sexual Health Clinic Attendees in Bucharest, Romania

International Journal of Dermatology, EarlyView.
Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4+ T cells.

PLoS Pathogens
Antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents HIV transmission. However, ART does not cure HIV infection because of a persistent, latent viral reservoir in long-lived cells such as central ...
Catherine A Lewis, David M Margolis, Edward P Browne   +2 more
doaj   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Medical Knowledge Integration Into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

International Statistical Review, EarlyView.
Summary The goal of precision medicine is to provide individualised treatment at each stage of chronic diseases, a concept formalised by dynamic treatment regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from clinical data to enhance therapeutic effectiveness.
Sophia Yazzourh, Nicolas Savy, Philippe Saint‐Pierre, Michael R. Kosorok   +3 more
wiley   +1 more source

Structural Vulnerability in Health Research: A Systematic Mixed Studies Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To systematically examine how structural vulnerability has been defined and operationalised in United States‐based health research, identify conceptual consistencies and methodological gaps, and propose core dimensions of structural vulnerability along with implications for future application in health research.
Levia A. Sutton, Carmen Alvarez, Therese S. Richmond, Sara F. Jacoby   +3 more
wiley   +1 more source

Use of Conventional Artificial Intelligence Methods in the Identification of Frailty: A Scoping Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Early identification and management of frailty are crucial, yet its detection in early stages remains difficult for clinicians. Artificial intelligence (AI) has emerged as a promising tool in healthcare. However, the absence of a standard frailty definition and diversity of AI methods create a need for a comprehensive review.
Kunal Ashok Dalsania, Alixe Ménard, Shruthi Sundararaman, Arya Rahgozar, Sarah de Lima, Xintong Lu, Aya Al‐Ali, Krishnpriya Singh, Ramtin Hakimjavadi, Hui Yan, Claire Sethuram, Howard Bergman, Jim LaPlante, Daniel McIsaac, Samira Abbasgholizadeh Rahimi, Nadia Sourial, Manpreet Thandi, Sabrina Wong, Clare Liddy, Karen Bandeen‐Roche, Sathya Karunananthan   +20 more
wiley   +1 more source

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
doaj   +1 more source

Role of long noncoding RNA in regulating HIV infection—a comprehensive review

mBio
A complete cure against human immunodeficiency virus (HIV) infection remains out of reach, as the virus persists in stable cell reservoirs that are resistant to antiretroviral therapy.
Noa Amir, Ran Taube
doaj   +1 more source

Health Screening and Post‐Arrival Services for Refugee Children From Afghanistan

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To examine refugee health screening and services for Afghan children in the unique context of emergency expedited humanitarian resettlement in Melbourne, Australia. Methods Retrospective audit of Afghan children who attended a specialist child refugee health service between August 2021–April 2024. Results Participants included 218 children
Amy Williamson, Eva Sudbury, Rija Khanal, Jade Woon, Jennifer Schaefer, Georgia Paxton   +5 more
wiley   +1 more source