Results 161 to 170 of about 799,404 (198)

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells. [PDF]

mBio
Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ.   +20 more
europepmc   +1 more source

The mTOR Complex Controls HIV Latency [PDF]

Cell Host and Microbe, 2016
A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on antiretroviral therapy, posing a barrier to HIV eradication.
Michael C Bassik, Erik Verschueren, Warner C Greene   +2 more
exaly   +7 more sources

HIV-1 Latency in Monocytes/Macrophages [PDF]

Viruses, 2014
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been established called the HIV-1 reservoir.
Wasim Abbas, Georges Herbein
exaly   +4 more sources

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Epigenetic regulation of HIV latency

Current Opinion in HIV and AIDS, 2011
A reservoir of latently infected cells remains in HIV-infected patients treated with highly active antiretroviral therapy treatment. Persistence of HIV in this latent reservoir has prevented full viral eradication. In order to understand and develop rational therapeutics to flush out HIV latency, the molecular mechanisms governing the phenomena of HIV ...
Shweta, Hakre, Leonard, Chavez, Kotaro, Shirakawa, Eric, Verdin   +3 more
openaire   +2 more sources

HIV replication and latency in monocytes and macrophages

Seminars in Immunology, 2021
The relevance of monocyte and macrophage reservoirs in virally suppressed people with HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a moderate life span and lack self-renewing potential. However, recent studies have challenged this dogma and now suggest an important role of these cell as long-lived HIV reservoirs ...
Rebecca T. Veenhuis, Celina M. Abreu, Erin N. Shirk, Lucio Gama, Janice E. Clements   +4 more
openaire   +2 more sources

Mechanisms of HIV-1 latency

AIDS, 1992
This review describes some of the virus-cell relationships that might contribute to the state of latency observed in HIV infection. Viruses use many mechanisms to persist in their host, and the molecular interactions evoked by the virus and the cell on each other can influence the outcome of an infection.
D P, Bednarik, T M, Folks
openaire   +2 more sources

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

Viruses, 2019
Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide.
Indra Sarabia, Alberto Bosque
exaly   +2 more sources

A unified concept of HIV latency

Expert Opinion on Biological Therapy, 2006
The introduction of highly active antiretroviral therapy (HAART) combining potent drugs that can inhibit reverse transcriptase, integrase and protease activities has changed the natural history of the human immunodeficiency virus (HIV) type 1 disease. Unfortunately, poor penetrability into different anatomic compartments, toxicity and drug resistance ...
openaire   +2 more sources