Results 81 to 90 of about 32,363 (272)

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

The Influence of Ethical Ideologies on Corporate Social Performance in Small and Medium‐Sized Enterprises in the United Kingdom

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Research addressing the microfoundations of corporate social performance (CSP) in small and medium‐sized enterprises (SMEs) remains sparse. This paper aims to investigate how SME managers' ethical ideology affects CSP and examines the mediating role of their CSR orientation (CSRO): economic, legal, ethical, and philanthropic.
Sarah Mohammad Suleiman Alsyoof, Vasa László, Tamás Sneider   +2 more
wiley   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Exploring HIV latency using transcription profiling

, 2017
The major barrier to a cure for HIV is the existence of reservoirs consisting predominantly of latently infected CD4+ T cells, which do not produce virus constitutively but can be induced to produce infectious virus on activation.
Sushama Telwatte, Steven A Yukl
core   +1 more source

Maternal infection in the context of actively managed prelabor rupture of membranes at term: An observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess maternal infection following prelabor rupture of membranes (PROM) at term in a setting where active management is recommended, and to identify associated risk factors. Methods A retrospective cohort study was conducted including pregnant women admitted to a Portuguese tertiary care center where immediate induction of labor ...
Inês Martins, Inês Gomes Brou, Miguel Macedo, Luísa Pinto   +3 more
wiley   +1 more source

Generation of HIV Latency in Humanized BLT Mice [PDF]

Journal of Virology, 2012
ABSTRACT Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4 + T ...
Denton, Paul W., Olesen, Rikke; id_orcid 0000-0002-5157-080X, Choudhary, Shailesh K, Archin, Nancy M, Wahl, Angela, Swanson, Michael D, Chateau, Morgan, Nochi, Tomonori, Krisko, John F, Spagnuolo, Rae Ann, Margolis, David M, Garcia, J Victor   +11 more
openaire   +3 more sources

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Clinical Epigenetics, 2018
HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan, Mazhar Iqbal, Muhammad Tariq, Shahid M. Baig, Wasim Abbas   +4 more
doaj   +1 more source

Mathematical Analysis of the Role of HIV/HBV Latency in Hepatocytes

Journal of Applied Mathematics, 2021
The biggest challenge of treating HIV is rampant liver-related morbidity and mortality. This is, to some extent, attributed to hepatocytes acting as viral reservoirs to both HIV and HBV. Viral reservoirs harbour latent provirus, rendering it inaccessible
Hasifa Nampala, Matylda Jablonska-Sabuka, Martin Singull   +2 more
doaj   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source