Results 81 to 90 of about 32,488 (258)

An Integrated Overview of HIV-1 Latency [PDF]

Cell, 2013
Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs.
Ruelas, Debbie S, Greene, Warner C
openaire   +4 more sources

HTLV-1 Tax activates HIV-1 transcription in latency models. [PDF]

, 2017
HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription.
Amilcar Tanuri, Leal, Fabio E, Tanuri, Amilcar, Nixon, Douglas F, Aguiar, Renato Santana, José, Diego Pandeló, Diego Pandeló José, Douglas F. Nixon, Fabio E. Leal, Victor Emmanuel Viana Geddes, Geddes, Victor Emmanuel Viana, Renato Santana de Aguiar   +11 more
core   +1 more source

Maternal infection in the context of actively managed prelabor rupture of membranes at term: An observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess maternal infection following prelabor rupture of membranes (PROM) at term in a setting where active management is recommended, and to identify associated risk factors. Methods A retrospective cohort study was conducted including pregnant women admitted to a Portuguese tertiary care center where immediate induction of labor ...
Inês Martins, Inês Gomes Brou, Miguel Macedo, Luísa Pinto   +3 more
wiley   +1 more source

Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal.

PLoS ONE, 2019
The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency ...
Wim Trypsteen, Cory H White, Amey Mukim, Celsa A Spina, Ward De Spiegelaere, Steve Lefever, Vicente Planelles, Alberto Bosque, Christopher H Woelk, Linos Vandekerckhove, Nadejda Beliakova-Bethell   +10 more
doaj   +1 more source

Mental health measures among adolescents in 12 low‐ and middle‐income countries: Measurement invariance and cross‐sectional analyses of Disrupting Harm survey data

JCPP Advances, EarlyView.
Abstract Background Nationally representative mental health data in adolescents from low‐ and middle‐income countries (LMICs) are scarce. This study aimed to examine mental health and wellbeing indicators amongst adolescents in 12 LMICs across Eastern and Southern Africa and Southeast Asia. Methods We conducted a secondary analysis of data involving 12,
Ariadna Albajara Sáenz, Sebastian Kurten, Jennifer Saxton, Daniel Kardefelt‐Winther, Tamsin Ford, Amy Orben, Simon R. White   +6 more
wiley   +1 more source

A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency

mBio
Antiretroviral therapy suppresses HIV replication but fails to eliminate the virus due to the persistence of a transcriptionally silent reservoir, which remains the primary barrier to a cure.
Samuel D. Burgos, Airlie M. Ward, Manickam Ashokkumar, Kimberly P. Enders, Lindsey I. James, David M. Margolis, Edward P. Browne   +6 more
doaj   +1 more source

Associations between health care access and posttraumatic stress disorder symptoms among rural and urban lesbian, gay, bisexual, transgender, and queer adults

Journal of Traumatic Stress, EarlyView.
Abstract Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) individuals experience elevated rates of trauma exposure, minority stress, and posttraumatic stress disorder (PTSD). Yet, research examining how geographic location and LGBTQ+ identity shape PTSD outcomes is scant, particularly studies considering structural facilitators and barriers ...
Emily A. Kenyon, Michelle A. Stage, Reina Kiefer, Mollie A. Ruben, Nicholas A. Livingston, Danielle S. Berke, Jillian C. Shipherd   +6 more
wiley   +1 more source

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +1 more source

The dialectics of trauma and political conscientization: A psychosocial study of activism for supporting sexual and gender minoritized communities in Brazil

Journal of Traumatic Stress, EarlyView.
Abstract This qualitative study examined the dialectical association between psychosocial trauma and political conscientization in the lives of activists advocating for persons with marginalized sexual orientations and gender identities (2SLGBTQIA+) in São José dos Campos, Brazil.
Gab C. Siqueira, Luisa F. Velásquez Vallejo, Antonio Euzebios Filho   +2 more
wiley   +1 more source

Intersectional discrimination, identity conflict, and posttraumatic stress symptoms among bisexual+ people of color

Journal of Traumatic Stress, EarlyView.
Abstract Bisexual and other multigender‐attracted (e.g., pansexual, queer) people (bi+) report disproportionately high posttraumatic stress symptoms (PTSS) linked to a high frequency of discrimination and general trauma exposure. Bi+ people of color (POC) may be particularly vulnerable to PTSS given exposure to intersectional discrimination (e.g ...
Roberto Rentería, Jacquie Mitzner, Diana Kaziyev, Nicholas A. Livingston, Emily Bettin, Brian A. Feinstein   +5 more
wiley   +1 more source