Results 61 to 70 of about 120,919 (245)

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

PLoS Pathogens, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa   +13 more
doaj   +1 more source

Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]

, 2012
OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)
López-Diéguez, María, Babiker, A, Myra McClure (309188), Porter, Kholoud, Jonathan Weber (59115), Phillips, R, Pedersen, Court, Giuseppe Tambussi (237799), Jason F Okulicz (16174841), Weber, Jonathan, Tambussi, G, Weber, J, Hamlyn Elizabeth, Miró Meda, José M. (José María), 1956-, García, M. T., Abdel Babiker (225813), Hamlyn, E, Schechter, M, Pedersen Court, Court Pedersen (38784), Hamlyn, Elizabeth, Jason F Okulicz, Elizabeth Hamlyn (309179), Cooper David A., Manzardo, Christian, Tambussi, Giuseppe, McClure, Myra, Schechter, Mauro, Jonathan Weber, Babiker Abdel, Plana Prades, Montserrat, Kholoud Porter, Abdel Babiker, Cooper, David A, Kholoud Porter (252703), Emery, Sean, Okulicz Jason F., Fiona M Ewings, Cooper, DA, INSIGHT SMART, David A Cooper (16165874), Court Pedersen, SPARTAC Trial Investigators, INSIGHT SMART and SPARTAC Investigators, Phillips, Rodney, Fidler Sarah, Myra McClure, Ligero, M. C., Pedersen, C, Elizabeth Hamlyn, Pumarola Suñé, Tomàs, Tuset Creus, Montserrat, Porter, K, Schechter Mauro, McClure, M, Mauro Schechter, Babiker, Abdel, Ewings, FM, The INSIGHT SMART and SPARTAC Investigators (16174844), Martin Fisher (300134), Fidler, S, Okulicz, Jason F., McClure Myra, Arnaiz Gargallo, Juan Alberto, Cooper, David A., Giuseppe Tambussi, Sarah Fidler, Weber Jonathan, Sarah Fidler (76851), Ewings, Fiona M., Okulicz, JF, Gatell, José M., Fidler, Sarah, Okulicz, Jason F, David A Cooper, SPARTAC Investigator, Tambussi Giuseppe, Mauro Schechter (4928), INSIGHT SMART Investigator, Fiona M Ewings (16174838), Ewings Fiona M., Porter Kholoud, Gallart, Teresa, Ewings, Fiona M   +83 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study. [PDF]

, 2011
BACKGROUND: Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost.
Van de Perre, Philippe, Nagot, N., Segondy, M., Abdoulaye Ouedraogo, Huet, C., Tim Clayton, Yérélon Cohort Study Group, Didelot-Rousseau, Marie-Noelle, Nagot, Nicolas, Clayton, T., Low, Andrea J, Ouedraogo, Abdoulaye, Yérélon Cohort Study Group (collab.), Ouedraogo, A., Charlotte Huet, Clayton, Tim, Konate, I., Segondy, Michel, Didelot-Rousseau, M., Van de Perre, P., Becquart, Pierre (collab.), Andrea J Low, Mayaud, Philippe, Mayaud, P., Huet, Charlotte, Philippe Van de Perre, Nicolas Nagot, null null, Konate, Issouf, Low, A.J., Philippe Mayaud, Michel Segondy, Issouf Konate, Marie-Noelle Didelot-Rousseau   +33 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Primary HIV-1 resistance: Persistence of transmitted drug resistance mutations [PDF]

Archives of Biological Sciences, 2012
Transmitted drug resistance (TDR) is one of the consequences of the high variability of HIV-1. The widespread use of antiretroviral therapy for the treatment of HIV-1 infection results in a large circulating pool of resistant virus variants.
Nikolić Valentina, Salemović D., Jevtović Đ., Pešić-Pavlović I., Zerjav S., Ranin J., Siljić M., Stanojević M.   +7 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV

Cell Reports Medicine
Summary: Key HIV cure strategies involve reversing immune dysfunction and limiting the proliferation of infected T cells. We evaluate the safety of sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in people with HIV (PWH) and study the impact
Timothy J. Henrich, Ronald J. Bosch, Catherine Godfrey, Hanna Mar, Apsara Nair, Michael Keefer, Carl Fichtenbaum, Daniela Moisi, Brian Clagett, Amanda M. Buck, Amelia N. Deitchman, Francesca Aweeka, Jonathan Z. Li, Daniel R. Kuritzkes, Michael M. Lederman, Priscilla Y. Hsue, Steven G. Deeks, Danielle Campbell, Corey Cutler, Michael Dorosh, Belinda Ha, Elizabeth Hawkins, Christopher Hensel, Nayri Khairalla, Kevin Knowles, Sulggi A. Lee, Susan Pedersen, Justin Ritz, Dylan Ryder, Rafick Sekaly, David L. Shugarts, Becky Straub, Andrew Zolopa   +32 more
doaj   +1 more source

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

EBioMedicine, 2015
Background: Characterising the correlates of HIV persistence improves understanding of disease pathogenesis and guides the design of curative strategies.
Alessandra Ruggiero, Ward De Spiegelaere, Alessandro Cozzi-Lepri, Maja Kiselinova, Georgios Pollakis, Apostolos Beloukas, Linos Vandekerckhove, Matthew Strain, Douglas Richman, Andrew Phillips, Anna Maria Geretti, Paola Vitiello, Nicola Mackie, Jonathan Ainsworth, Anele Waters, Frank Post, Simon Edwards, Julie Fox   +17 more
doaj   +1 more source

Immunometabolism and HIV-1 pathogenesis: food for thought

, 2021
International audienceAntiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life. Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite treatment. There is, therefore, an urgent need to
Sáez-Cirión, Asier, Sereti, Irini
core   +1 more source