Results 61 to 70 of about 30,666,235 (182)

Genotypic alteration of HAART-persistent HIV-1 reservoirs in vivo

Virology, 2003
Three HIV-1-infected individuals, on virally-suppressive highly active anti-retroviral therapy (HAART), were treated in vivo with anti-retroviral inhibitor intensification and cell stimulatory therapies in attempting to eradicate latent viral reservoirs. Afterwards, the patients ceased all anti-retroviral drugs.
Kulkosky, Joseph, Sullivan, Julie, Xu, Yan, Malin-Markham, Anne, Otero, Miguel, Calarota, Sandra, Zielinski, Jennifer, Culnan, Derek M, Pomerantz, Roger J   +8 more
openaire   +2 more sources

Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence

Nature Communications
Initiation of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) has been proposed to limit the formation of HIV-1 reservoirs. However, it remains unknown whether temporary ART initiated during PHI has a long-term effect on viral ...
Alexander O. Pasternak, Pien M. van Paassen, Yara L. Verschoor, Jelmer Vroom, Karel A. van Dort, Irma Maurer, Marlous L. Grijsen, Ferdinand W. Wit, Godelieve J. de Bree, Neeltje A. Kootstra, Jan M. Prins, Ben Berkhout   +11 more
doaj   +1 more source

The HIV-1 Subtype C Epidemic in South America Is Linked to the United Kingdom [PDF]

, 2010
Background: The global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of ...
Gifford, RJ, Gifford Robert J., Pillay Deenan, Pillay, D, Tulio de Oliveira, UK Collaborative Grp HIV Drug Resi, Robert J Gifford, Deenan Pillay, de Oliveira, T, UK Collaborative Group on HIV Drug Resistance, de Oliveira Tulio   +10 more
core   +1 more source

Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4

Frontiers in Immunology, 2023
IntroductionHIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies.
Katie Fisher, Katie Fisher, Timothy E. Schlub, Zoe Boyer, Zoe Boyer, Thomas A. Rasmussen, Thomas A. Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M. Hecht, Steven G. Deeks, Sharon R. Lewin, Sharon R. Lewin, Sharon R. Lewin, Sarah Palmer, Sarah Palmer   +15 more
doaj   +1 more source

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

Nature Reviews Microbiology, 2014
Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected individuals to control infection and live long, productive lives. However, HIV-1 infection remains incurable owing to the persistence of a viral reservoir that harbours integrated provirus within host cellular DNA.
Nancie M, Archin, Julia Marsh, Sung, Carolina, Garrido, Natalia, Soriano-Sarabia, David M, Margolis   +4 more
openaire   +3 more sources

The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence [PDF]

The Journal of Immunology, 2016
Abstract Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to below the limit of detection of clinical assays. However, even with prolonged suppression of viral replication with ART, viremia rebounds rapidly after treatment interruption. Thus, ART is not curative.
Alexandra J Murray, Kyungyoon J Kwon, Donna L Farber, Robert F Siliciano   +3 more
openaire   +2 more sources

Outcomes for efavirenz versus nevirapine-containing regimens for treatment of HIV-1 infection: a systematic review and meta-analysis. [PDF]

, 2013
INTRODUCTION: There is conflicting evidence and practice regarding the use of the non-nucleoside reverse transcriptase inhibitors (NNRTI) efavirenz (EFV) and nevirapine (NVP) in first-line antiretroviral therapy (ART). METHODS: We systematically reviewed
Pillay, Prinitha, Prinitha Pillay (435496), Pillay Prinitha, Prinitha Pillay, Ford Nathan, Shubber Zara, Shubber, Zara, Ford, Nathan, Rashida A. Ferrand, Ferrand Rashida A., Nathan Ford, Ferrand, Rashida A, Nathan Ford (59436), Zara Shubber (279389), Rashida A. Ferrand (253679), Rashida A Ferrand, Zara Shubber   +16 more
core   +1 more source

Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes [PDF]

, 2012
BACKGROUND: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups.
Thomas Bodmer, Gagneux, Sebastien, Bodmer, Thomas, Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups, Schrenzel, J., Bottger, E. C., Schrenzel Jacques, Jean-Paul Janssens (174301), Cavassini Matthias, Matthias Egger, Enos Bernasconi (174329), Jacques Schrenzel, Egger, M., Böttger Erik C., Schrenzel, Jacques, Matthias Egger (24558), Böttger, E.C., Jan Fehr (174310), Fehr Jan, Janssens, J. P., Bodmer Thomas, Bernasconi, E., Gagneux, S., Fenner, Lukas, Egger, Matthias, Enos Bernasconi, Egger Matthias, Hoffmann, Matthias, Erik C. Böttger (174343), Cavassini, M., Matthias Hoffmann, Jacques Schrenzel (22586), Janssens, J.P., Böttger, Erik C, Helbling, Peter, Matthias Cavassini (146654), Gagneux Sebastien, Fenner, L., Matthias Hoffmann (174320), Peter Helbling (174346), Helbling, P., Bernasconi, Enos, Jan Fehr, Erik C Böttger, Thomas Bodmer (174337), Lukas Fenner, Fenner Lukas, Fehr, Jan, for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculo,, Janssens, Jean-Paul, Helbling Peter, Bernasconi Enos, Sebastien Gagneux (149824), Janssens Jean-Paul, Hoffmann, M., Hoffmann Matthias, Sebastien Gagneux, Peter Helbling, Lukas Fenner (149822), Jean-Paul Janssens, Fehr, J., Cavassini, Matthias, Bodmer, T., Matthias Cavassini   +63 more
core   +3 more sources

HIV-1 replicates and persists in vaginal epithelial dendritic cells

Journal of Clinical Investigation, 2018
HIV-1 acquisition occurs most commonly after sexual contact. To establish infection, HIV-1 must infect cells that support high-level replication, namely CD4+ T cells, which are absent from the outermost genital epithelium. Dendritic cells (DCs), present in mucosal epithelia, potentially facilitate HIV-1 acquisition. We show that vaginal epithelial DCs,
Victor Pena-Cruz, Luis M. Agosto, Hisashi Akiyama, Alex Olson, Yvetane Moreau, Jean-Robert Larrieux, Andrew Henderson, Suryaram Gummuluru, Manish Sagar   +8 more
openaire   +2 more sources

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. [PDF]

, 2010
BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression.
van Loggerenberg, Francois, Passmore, Jo-Ann Shelley., Burgers, Wendy A, Passmore, Jo-Ann S., Loggerenberg, Francois van, Bebell, Lisa M., Roberts, Lindi., Mlisana, Koleka Patience., Burgers, Wendy A., Passmore, Jo-Ann S, Roberts, Lindi, Mlisana, Koleka, Djoba Siawaya, Joel Fleury., Abdool Karim, Salim Safurdeen., Djoba Siawaya, Joel F., Williamson, Carolyn., Little, Francesca., Abdool Karim, Quarraisha, Mlisana, Koleka P., Djoba Siawaya, Joel F, Bebell, Lisa M, Karim, Quarraisha Abdool, Williamson, Carolyn, Walzl, Gerhard, Abdool Karim, Quarraisha., Abdool Karim, Salim, van Loggerenberg, Francois., Karim, Salim S Abdool, Little, Francesca, Walzl, Gerhard.   +29 more
core   +1 more source