Results 71 to 80 of about 30,666,235 (182)

The establishment of rodent cell lines persistently producing HIV-1

Virology, 1992
Animal cells differ in susceptibility to HIV-1 infection. To identify rodent cells which are permissive to HIV-1 replication, we transfected murine and rat cells with an infectious clone of HIV-1 and a vector containing the chloramphenicol acetyl transferase gene under the control of HIV-1 LTR.
Y, Mizrachi, L, Sternas, D J, Volsky
openaire   +2 more sources

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

PLoS Pathogens, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa   +13 more
doaj   +1 more source

Correlates of HIV-1 genital shedding in Tanzanian women. [PDF]

, 2011
BACKGROUND: Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who ...
Clare Tanton, David A. Ross, Watson-Jones Deborah, Weiss, Helen A, Watson-Jones, Deborah, Helen A Weiss, Richard J. Hayes, Laurent Belec, Tanton, Clare, Le Goff, Jerome, Hayes, Richard J, Deborah Watson-Jones, Le Goff Jerome, Belec Laurent, Baisley, Kathy, Changalucha John, Weiss Helen A., Everett Dean, Ross, David A, Everett, Dean, David A Ross, Kathy Baisley, Changalucha, John, Mary Rusizoka, Jerome Le Goff, Helen A. Weiss, John Changalucha, Tanton Clare, Dean Everett, Richard J Hayes, Baisley Kathy, Ross David A., Rusizoka, Mary, Rusizoka Mary, Hayes Richard J., Belec, Laurent   +35 more
core   +1 more source

Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV

Cell Reports Medicine
Summary: Key HIV cure strategies involve reversing immune dysfunction and limiting the proliferation of infected T cells. We evaluate the safety of sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in people with HIV (PWH) and study the impact
Timothy J. Henrich, Ronald J. Bosch, Catherine Godfrey, Hanna Mar, Apsara Nair, Michael Keefer, Carl Fichtenbaum, Daniela Moisi, Brian Clagett, Amanda M. Buck, Amelia N. Deitchman, Francesca Aweeka, Jonathan Z. Li, Daniel R. Kuritzkes, Michael M. Lederman, Priscilla Y. Hsue, Steven G. Deeks, Danielle Campbell, Corey Cutler, Michael Dorosh, Belinda Ha, Elizabeth Hawkins, Christopher Hensel, Nayri Khairalla, Kevin Knowles, Sulggi A. Lee, Susan Pedersen, Justin Ritz, Dylan Ryder, Rafick Sekaly, David L. Shugarts, Becky Straub, Andrew Zolopa   +32 more
doaj   +1 more source

Primary HIV-1 resistance: Persistence of transmitted drug resistance mutations [PDF]

Archives of Biological Sciences, 2012
Transmitted drug resistance (TDR) is one of the consequences of the high variability of HIV-1. The widespread use of antiretroviral therapy for the treatment of HIV-1 infection results in a large circulating pool of resistant virus variants.
Nikolić Valentina, Salemović D., Jevtović Đ., Pešić-Pavlović I., Zerjav S., Ranin J., Siljić M., Stanojević M.   +7 more
doaj   +1 more source

Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo:implications for models of HIV pathogenesis [PDF]

, 1991
Sequence change in different hypervariable regions of the external membrane glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1) was studied.
Zhang, L Q, Brown, A J, Balfe, P, McOmish, F, Ludlam, C A, Simmonds, P   +5 more
core  

Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression [PDF]

, 2010
Background: Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by
Scheuring Urban J, Oliver G Ottmann, Dietrich, Ursula, Capalbo Gianni, Scheuring, Urban J., Ursula Dietrich, Ottmann, Oliver G., Dietrich Ursula, Gianni Capalbo, Urban J Scheuring, Hoelzer, Dieter (Prof. Dr.), Müller-Kuller Thea, Hoelzer Dieter, Ottmann Oliver G, Dieter Hoelzer, Thea Müller-Kuller, Capalbo, Gianni, Müller-Kuller, Thea   +17 more
core   +1 more source

HIV persistence in tissues on dolutegravir-based therapy is not associated with resistance mutations to dolutegravir

Communications Medicine
Background Relatively few studies have investigated HIV-1 persistence in tissues, especially in healthy people-living-with-HIV-1 (PLWH) on a successful antiretroviral regimen containing second generation integrase inhibitors.
Gilbert Mchantaf, Adeline Melard, Kévin Da Silva, Elise Gardiennet, Antoine Chaillon, Bénédicte Lefebvre, Jade Ghosn, Olivier Robineau, Jean-Paul Viard, Lucie Adoux, Frédéric Lemoine, Aurélie Barrail-Tran, Sylvie Orr, Fatoumata Coulibaly, Laurence Meyer, Antoine Cheret, Véronique Avettand-Fenoel   +16 more
doaj   +1 more source

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

EBioMedicine, 2015
Background: Characterising the correlates of HIV persistence improves understanding of disease pathogenesis and guides the design of curative strategies.
Alessandra Ruggiero, Ward De Spiegelaere, Alessandro Cozzi-Lepri, Maja Kiselinova, Georgios Pollakis, Apostolos Beloukas, Linos Vandekerckhove, Matthew Strain, Douglas Richman, Andrew Phillips, Anna Maria Geretti, Paola Vitiello, Nicola Mackie, Jonathan Ainsworth, Anele Waters, Frank Post, Simon Edwards, Julie Fox   +17 more
doaj   +1 more source

Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors [PDF]

, 2005
Background: Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human cells expressing both CD4 and an ...
Sandra Siegert, Barbara S Schnierle, Schnierle Barbara S, Wagner Ralf, Ralf Wagner, Thaler Sonja, Siegert, Sandra, Schnierle, Barbara, Siegert Sandra, Thaler, Sonja, Wagner, Ralf, Sonja Thaler   +11 more
core   +1 more source