Results 81 to 90 of about 121,361 (282)
Impaired antibody response causes persistence of prototypic T cell-contained virus [PDF]
, 2009 CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control André Fitsche, Bruno Eschli, Lukas Flatz, Senn, Beatrice M., Marylise Fernandez, Ahmed N Hegazy, Verbeek, J Sjef, Eschli, Bruno, Fink, Katja, Rami Sommerstein, Doron Merkler, Daniel D Pinschewer, Katja Fink, Siegrist, Claire-Anne, Odermatt, Bernhard, Andreas Bergthaler, Horvath, Edit, Fitsche, André, Bergthaler, Andreas, Claire-Anne Siegrist, Holdener, Martin, Beatrice M Senn, Verbeek, J. Sjef, Admar Verschoor, J Sjef Verbeek, Verschoor, Admar, Merkler, Doron, Edit Horvath, Pinschewer, Daniel, Martin Holdener, Bernhard Odermatt, Flatz, Lukas, Pinschewer, Daniel D., Sommerstein, Rami, Hegazy, Ahmed N., Fernandez, Marylise +35 morecore +1 more sourceRNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection
Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu +13 morewiley +1 more sourceEffector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.
PLoS Pathogens, 2019 Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa +13 moredoaj +1 more sourceSomatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants
Advanced Science, EarlyView.Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok +14 morewiley +1 more sourcePlasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]
, 2012 OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)López-Diéguez, María, Babiker, A, Myra McClure (309188), Porter, Kholoud, Jonathan Weber (59115), Phillips, R, Pedersen, Court, Giuseppe Tambussi (237799), Jason F Okulicz (16174841), Weber, Jonathan, Tambussi, G, Weber, J, Hamlyn Elizabeth, Miró Meda, José M. (José María), 1956-, García, M. T., Abdel Babiker (225813), Hamlyn, E, Schechter, M, Pedersen Court, Court Pedersen (38784), Hamlyn, Elizabeth, Jason F Okulicz, Elizabeth Hamlyn (309179), Cooper David A., Manzardo, Christian, Tambussi, Giuseppe, McClure, Myra, Schechter, Mauro, Jonathan Weber, Babiker Abdel, Plana Prades, Montserrat, Kholoud Porter, Abdel Babiker, Cooper, David A, Kholoud Porter (252703), Emery, Sean, Okulicz Jason F., Fiona M Ewings, Cooper, DA, INSIGHT SMART, David A Cooper (16165874), Court Pedersen, SPARTAC Trial Investigators, INSIGHT SMART and SPARTAC Investigators, Phillips, Rodney, Fidler Sarah, Myra McClure, Ligero, M. C., Pedersen, C, Elizabeth Hamlyn, Pumarola Suñé, Tomàs, Tuset Creus, Montserrat, Porter, K, Schechter Mauro, McClure, M, Mauro Schechter, Babiker, Abdel, Ewings, FM, The INSIGHT SMART and SPARTAC Investigators (16174844), Martin Fisher (300134), Fidler, S, Okulicz, Jason F., McClure Myra, Arnaiz Gargallo, Juan Alberto, Cooper, David A., Giuseppe Tambussi, Sarah Fidler, Weber Jonathan, Sarah Fidler (76851), Ewings, Fiona M., Okulicz, JF, Gatell, José M., Fidler, Sarah, Okulicz, Jason F, David A Cooper, SPARTAC Investigator, Tambussi Giuseppe, Mauro Schechter (4928), INSIGHT SMART Investigator, Fiona M Ewings (16174838), Ewings Fiona M., Porter Kholoud, Gallart, Teresa, Ewings, Fiona M +83 morecore +1 more sourceTargeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity
Advanced Science, EarlyView.This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang +9 morewiley +1 more sourceGenital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study. [PDF]
, 2011 BACKGROUND: Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost.Van de Perre, Philippe, Nagot, N., Segondy, M., Abdoulaye Ouedraogo, Huet, C., Tim Clayton, Yérélon Cohort Study Group, Didelot-Rousseau, Marie-Noelle, Nagot, Nicolas, Clayton, T., Low, Andrea J, Ouedraogo, Abdoulaye, Yérélon Cohort Study Group (collab.), Ouedraogo, A., Charlotte Huet, Clayton, Tim, Konate, I., Segondy, Michel, Didelot-Rousseau, M., Van de Perre, P., Becquart, Pierre (collab.), Andrea J Low, Mayaud, Philippe, Mayaud, P., Huet, Charlotte, Philippe Van de Perre, Nicolas Nagot, null null, Konate, Issouf, Low, A.J., Philippe Mayaud, Michel Segondy, Issouf Konate, Marie-Noelle Didelot-Rousseau +33 morecore +1 more sourceSirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV
Cell Reports MedicineSummary: Key HIV cure strategies involve reversing immune dysfunction and limiting the proliferation of infected T cells. We evaluate the safety of sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in people with HIV (PWH) and study the impact Timothy J. Henrich, Ronald J. Bosch, Catherine Godfrey, Hanna Mar, Apsara Nair, Michael Keefer, Carl Fichtenbaum, Daniela Moisi, Brian Clagett, Amanda M. Buck, Amelia N. Deitchman, Francesca Aweeka, Jonathan Z. Li, Daniel R. Kuritzkes, Michael M. Lederman, Priscilla Y. Hsue, Steven G. Deeks, Danielle Campbell, Corey Cutler, Michael Dorosh, Belinda Ha, Elizabeth Hawkins, Christopher Hensel, Nayri Khairalla, Kevin Knowles, Sulggi A. Lee, Susan Pedersen, Justin Ritz, Dylan Ryder, Rafick Sekaly, David L. Shugarts, Becky Straub, Andrew Zolopa +32 moredoaj +1 more source
