Results 101 to 110 of about 30,666,235 (182)

Fighting HIV-1 Persistence: At the Crossroads of "Shoc-K and B-Lock". [PDF]

Pathogens, 2021
Acchioni C, Palermo E, Sandini S, Acchioni M, Hiscott J, Sgarbanti M.   +5 more
europepmc   +1 more source

Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses. [PDF]

Trends Immunol, 2022
Linden N, Jones RB.
europepmc   +1 more source

Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapyResearch in context

EBioMedicine
Summary: Background: The persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to the high number of infected target cells.
Camille Vellas, Manon Nayrac, Nived Collercandy, Mary Requena, Nicolas Jeanne, Justine Latour, Chloé Dimeglio, Michelle Cazabat, Karl Barange, Laurent Alric, Nicolas Carrere, Guillaume Martin-Blondel, Jacques Izopet, Pierre Delobel   +13 more
doaj   +1 more source

Associations Between Multiple Measures of HIV-1 Persistence in Persons on Suppressive Antiretroviral Therapy. [PDF]

J Infect Dis, 2022
Bosch RJ, Gandhi RT, Mar H, Eron JJ, Cyktor JC, McMahon DK, Mellors JW.   +6 more
europepmc   +1 more source

Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection [PDF]

, 2003
Although the pathogenesis of human immunodeficiency virus (HIV) infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, there are unique considerations needed ...
Health Resources and Services Administration, HRSA, National Institutes of Health, NIH, Antiretroviral Therapy and Medical Management of HIV-Infected Children, ATMMHC, National Pediatric and Family HIV Resource Center, NPHRC   +3 more
core  

A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro. [PDF]

Cell Rep Methods, 2021
Eshetu A, Ho YC.
europepmc   +1 more source

Persistent HIV-1 transcription during ART: time to reassess its significance?

Current Opinion in HIV and AIDS
Purpose of review Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and reignite viral replication if therapy is interrupted. Persistence of the viral reservoir in people with HIV-1 (PWH) is the main obstacle to an HIV-1 cure. The reservoirs are not transcriptionally silent, and viral transcripts can be
Fombellida-Lopez, Céline, Berkhout, Ben, Darcis, Gilles, Pasternak, Alexander O   +3 more
openaire   +4 more sources

The ENL-USP7 complex regulates HIV latency through BRD4 protein stabilization

Cell Reports
Summary: HIV persistence in CD4 + T cells and brain microglia is maintained by host mechanisms that enforce viral latency. We identify ENL and the deubiquitinase USP7 as a host complex that sustains HIV latency.
Waqas Ahmed, Xiaoyi Li, Ciniso S. Shabangu, Hongjie Chen, Nikesh Katuwal, Jennifer Kirchherr, Wenshe R. Liu, Xin Li, Yongcheng Song, Kaixiu Luo, H. Umit Kaniskan, Jian Jin, Sara Gianella, David M. Margolis, Nancie M. Archin, Yuyang Tang, Guochun Jiang   +16 more
doaj   +1 more source

Pharmacologic control of homeostatic and antigen-driven proliferation to target HIV-1 persistence. [PDF]

Biochem Pharmacol, 2021
Innis EA, Levinger C, Szaniawski MA, Williams ESCP, Alcamí J, Bosque A, Schiffer JT, Coiras M, Spivak AM, Planelles V.   +9 more
europepmc   +1 more source

CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. [PDF]

Nat Commun, 2022
Baiyegunhi OO, Mann J, Khaba T, Nkosi T, Mbatha A, Ogunshola F, Chasara C, Ismail N, Ngubane T, Jajbhay I, Pansegrouw J, Dong KL, Walker BD, Ndung'u T, Ndhlovu ZM.   +14 more
europepmc   +1 more source