Results 41 to 50 of about 30,642,264 (240)

Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1 [PDF]

Science, 2006
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir.
Keele, B. F., Van Heuverswyn, F., Li, Y.Y., Bailes, E., Takehisa, J., Santiago, M. L., Bibollet Ruche, F., Chen, Y. L., Wain, L. V., /Liégeois, Florian, Loul, S., Mpoudi Ngolé, E., Bienvenue, Y., /Delaporte, Eric, Brookfield, J. F. Y., Sharp, P. M., Shaw, G. M., /Peeters, Martine, Hahn, B. H.   +18 more
openaire   +6 more sources

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

Viruses, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts, Basiel Cole, Sofie Rutsaert, Wim Trypsteen, Linos Vandekerckhove   +4 more
doaj   +1 more source

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection [PDF]

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Pellegrino, P, Groppelli, E, Elisabetta Groppelli (258517), Jolly, C, Ian Williams (208301), Changwang Zhang (716808), Persephone Borrow, Borrow, P, Chain, BM, Benjamin M Chain, Zhou, S, Zhou, Shi, Groppelli, Elisabetta, Persephone Borrow (194557), Ian Williams, Zhang, Changwang, Pellegrino, Pierre, Changwang Zhang, Jolly, Clare, Elisabetta Groppelli, Shi Zhou, Clare Jolly (207781), Pierre Pellegrino (208300), Benjamin M. Chain (154754), Pierre Pellegrino, Williams, Ian, Borrow, Persephone, Shi Zhou (452014), Zhang, C, Chain, Benjamin M., Williams, I, Clare Jolly   +31 more
core   +1 more source

Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients

Retrovirology, 2007
Background The presence of HIV-1 preintegration reservoir was assessed in an in vitro experimental model of latent HIV-1 infection, and in patients treated or not with highly active antiretroviral therapy (HAART).
Baillat Vincent, Mettling Clement, Tuaillon Edouard, Al Tabaa Yassine, Petitjean Gaël, Reynes Jacques, Segondy Michel, Vendrell Jean   +7 more
doaj   +1 more source

Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure

Cells, 2021
Effective antiretroviral therapy has led to significant human immunodeficiency virus type 1 (HIV-1) suppression and improvement in immune function. However, the persistence of integrated proviral DNA in latently infected reservoir cells, which drive ...
Grant R. Campbell, Stephen A. Spector
doaj   +1 more source

Characterisation of the HIV-1 reservoir and the potential for viral eradication [PDF]

, 2014
The HIV-1 reservoir is the major barrier to eradication and cure of HIV-1 infection. The aim of this thesis was to characterise the HIV-1 reservoir in PHI and to investigate two potential reservoir clearance strategies.
Williams, James P
core   +1 more source

Cervicovaginal HIV-1 shedding in women taking antiretroviral therapy in Burkina Faso: a longitudinal study. [PDF]

, 2013
BACKGROUND: Antiretroviral therapy (ART) reduces transmission of HIV-1. However, genital HIV-1 can be detected in patients on ART. We analyzed factors associated with genital HIV-1 shedding among high-risk women on ART in Burkina Faso.
Kania, Dramane, Segondy, Michel, Mabey, David, Meda, Nicolas, Weiss, Helen A, Vickerman, Peter, van de Perre, Philippe, Nagot, Nicolas, Low, Andrea, Mayaud, Philippe, ?, ?, Low, Andrea J, Pillay, Deenan, Konate, Issouf, Yerelon Study Group, Weiss, Helen, Pillay, Deenan,   +16 more
core   +1 more source

Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]

, 2012
OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)
López-Diéguez, María, Babiker, A, Myra McClure (309188), Porter, Kholoud, Jonathan Weber (59115), Phillips, R, Pedersen, Court, Giuseppe Tambussi (237799), Jason F Okulicz (16174841), Weber, Jonathan, Tambussi, G, Weber, J, Hamlyn Elizabeth, Miró Meda, José M. (José María), 1956-, García, M. T., Abdel Babiker (225813), Hamlyn, E, Schechter, M, Pedersen Court, Court Pedersen (38784), Hamlyn, Elizabeth, Jason F Okulicz, Elizabeth Hamlyn (309179), Cooper David A., Manzardo, Christian, Tambussi, Giuseppe, McClure, Myra, Schechter, Mauro, Jonathan Weber, Babiker Abdel, Plana Prades, Montserrat, Kholoud Porter, Abdel Babiker, Cooper, David A, Kholoud Porter (252703), Emery, Sean, Okulicz Jason F., Fiona M Ewings, Cooper, DA, INSIGHT SMART, David A Cooper (16165874), Court Pedersen, SPARTAC Trial Investigators, INSIGHT SMART and SPARTAC Investigators, Phillips, Rodney, Fidler Sarah, Myra McClure, Ligero, M. C., Pedersen, C, Elizabeth Hamlyn, Pumarola Suñé, Tomàs, Tuset Creus, Montserrat, Porter, K, Schechter Mauro, McClure, M, Mauro Schechter, Babiker, Abdel, Ewings, FM, The INSIGHT SMART and SPARTAC Investigators (16174844), Martin Fisher (300134), Fidler, S, Okulicz, Jason F., McClure Myra, Arnaiz Gargallo, Juan Alberto, Cooper, David A., Giuseppe Tambussi, Sarah Fidler, Weber Jonathan, Sarah Fidler (76851), Ewings, Fiona M., Okulicz, JF, Gatell, José M., Fidler, Sarah, Okulicz, Jason F, David A Cooper, SPARTAC Investigator, Tambussi Giuseppe, Mauro Schechter (4928), INSIGHT SMART Investigator, Fiona M Ewings (16174838), Ewings Fiona M., Porter Kholoud, Gallart, Teresa, Ewings, Fiona M   +83 more
core   +1 more source

HIV-1 infection and the central nervous system: investigating markers of neural activation and measures of HIV-1 reservoir

, 2021
Despite successful antiretroviral therapy (ART), mild cognitive impairments remain prevalent amongst people-living-with-HIV (PLWH). However, the underlying mechanisms driving this remain unclear.
Alagaratnam, Jasmini
core   +1 more source

B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 ⁺ T Cells: Implications for the Viral Reservoir

mBio, 2021
The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-competent
Abigail Gerberick, Diana C. DeLucia, Paolo Piazza, Mounia Alaoui-El-Azher, Charles R. Rinaldo, Nicolas Sluis-Cremer, Giovanna Rappocciolo   +6 more
doaj   +1 more source