Results 1 to 10 of about 3,725,865 (331)

Clonal Expansion in Cardiovascular Pathology [PDF]

JACC Basic To Translational Science, 2023
Summary: Clonal expansion refers to the proliferation and selection of advantageous “clones” that are better suited for survival in a Darwinian manner.
Edward A Fisher, Judith C Sluimer, Stefanie Dimmeler   +2 more
exaly   +8 more sources

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion

Cell Reports, 2017
Preadipocytes initiate differentiation into adipocytes through a cascade of events. Mitotic clonal expansion, as one of the earliest events, is essential for adipogenesis.
Chu-Xia Deng, Xiaoling Xu, Cuiying Xiao
exaly   +5 more sources

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Viruses, 2021
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Frank Maldarelli, Chuen-Yen Lau, Matthew A Adan   +2 more
exaly   +4 more sources

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory [PDF]

Nature Immunology, 2022
Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural killer ...
Leif S Ludwig, Chiara Romagnani, Mir-Farzin Mashreghi   +2 more
exaly   +3 more sources

Clonal expansion in normal tissues. [PDF]

Cancer Sci
Cancer originates from a single ancestral cell that acquires a driver mutation, which confers a growth or survival advantage, followed by the acquisition of additional driver mutations by descendant cells.
Maeda H, Kakiuchi N.
europepmc   +6 more sources

Clonal expansion of innate and adaptive lymphocytes

Nature Reviews Immunology, 2020
One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of individual cell clones that encounter their cognate antigen.
Nicholas M. Adams, Joseph C Sun, Simon Grassmann   +2 more
exaly   +4 more sources

Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis. [PDF]

JCI Insight
Clonal hematopoiesis of indeterminate potential (CHIP) is the expansion of blood stem cells and progeny after somatic mutation. CHIP associates with increased cardiovascular disease (CVD), with inflammation from macrophages a proposed common effector ...
Paul R. Carter, Lauren Kitt, Amanda C. Rodgers, Nichola Figg, Ang Zhou, Chengrui Zhu, Ziyang Wang, Peter Libby, Stephen Burgess, George S. Vassiliou, Murray C.H. Clarke   +10 more
doaj   +4 more sources

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +2 more sources

The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence

Viruses, 2021
More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound.
Yang-Hui Jimmy Yeh, Kerui Yang, Anya Razmi, Ya-Chi Ho   +3 more
doaj   +2 more sources

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans.

PLoS Pathogens, 2019
Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if there is
Andrea L Ferris, David W Wells, Shuang Guo, Gregory Q Del Prete, Adrienne E Swanstrom, John M Coffin, Xiaolin Wu, Jeffrey D Lifson, Stephen H Hughes   +8 more
doaj   +2 more sources