Results 1 to 10 of about 107,781 (288)
Clonal Expansion in Cardiovascular Pathology [PDF]
JACC: Basic to Translational ScienceSummary: Clonal expansion refers to the proliferation and selection of advantageous “clones” that are better suited for survival in a Darwinian manner.
Alexander Lin, BEng (Hons) +6 more
doaj +9 more sources
Clonal expansion in normal tissues. [PDF]
Cancer SciAbstractCancer originates from a single ancestral cell that acquires a driver mutation, which confers a growth or survival advantage, followed by the acquisition of additional driver mutations by descendant cells. Recently, it has become evident that somatic cell mutations accumulate in normal tissues with aging and exposure to environmental factors ...
Maeda H, Kakiuchi N.
europepmc +7 more sources
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion
Cell Reports, 2017 Preadipocytes initiate differentiation into adipocytes through a cascade of events. Mitotic clonal expansion, as one of the earliest events, is essential for adipogenesis.
Qiang Chen +7 more
doaj +4 more sources
Viruses, 2021 Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Chuen-Yen Lau +2 more
doaj +3 more sources
Dynamics of latent HIV under clonal expansion.
PLoS Pathogens, 2021 The HIV latent reservoir exhibits slow decay on antiretroviral therapy (ART), impacted by homeostatic proliferation and activation. How these processes contribute to the total dynamic while also producing the observed profile of sampled latent clone ...
John M Murray
doaj +4 more sources
Clonal hematopoiesis: elements associated with clonal expansion and diseases. [PDF]
Blood ResAbstract Clonal hematopoiesis (CH), characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, has emerged as a significant age-related phenomenon with profound implications for human health. While initially recognized in the 1960s, recent technological advances have revealed its complex nature and ...
Ryu G, Koh Y, Jaiswal S, Yoon SS.
europepmc +3 more sources
Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells [PDF]
Genome BiologyBackground Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues.
Xin Wang +11 more
doaj +2 more sources
Bayesian Inference of Clonal Expansions in a Dated Phylogeny [PDF]
Systematic Biology, 2021 Abstract Microbial population genetics models often assume that all lineages are constrained by the same population size dynamics over time. However, many neutral and selective events can invalidate this assumption and can contribute to the clonal expansion of a specific lineage relative to the rest of the population.
David Helekal +4 more
openaire +3 more sources
Using DNA methylation patterns to infer tumor ancestry. [PDF]
PLoS ONE, 2010 Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells.
You Jin Hong +3 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL ...
James J. Anderson +6 more
doaj +1 more source