Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs. [PDF]
PLoS Genetics, 2018 Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown.
August Yue Huang +6 more
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Resolving the Enigma of the Clonal Expansion of mtDNA Deletions [PDF]
Genes, 2018 Mitochondria are cell organelles that are special since they contain their own genetic material in the form of mitochondrial DNA (mtDNA). Damage and mutations of mtDNA are not only involved in several inherited human diseases but are also widely thought to play an important role during aging. In both cases, point mutations or large deletions accumulate
Axel Kowald, Thomas Kirkwood
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Effects of Cu Pollution on the Expansion of an Amphibious Clonal Herb in Aquatic-Terrestrial Ecotones. [PDF]
PLoS ONE, 2016 Physiological integration can enhance the performance of clonal plants in aquatic and terrestrial heterogeneous habitats and associated ecotones. Similar to nutrients, pollutants may be transported among connected ramets via physiological integration ...
Liang Xu, Zhen-Feng Zhou
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iScience, 2023 Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster.
Ellie N. Ivanova +20 more
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Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)
Experimental Hematology & Oncology, 2019 Background Large clonal populations of cells bearing PIG-A mutations are the sine qua non of PNH, but the PIG-A mutation itself is insufficient for clonal expansion.
Camille Lobry +5 more
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Investigating the relation between Stochastic Differentiation, Homeostasis and Clonal Expansion in Intestinal Crypts via Multiscale Modeling [PDF]
, 2014 Colorectal tumors originate and develop within intestinal crypts. Even though some of the essential phenomena that characterize crypt structure and dynamics have been effectively described in the past, the relation between the differentiation process and
De Matteis Giovanni +19 more
core +1 more source
Computational identification of clonal cells in single-cell CRISPR screens
BMC Genomics, 2022 Background Single-cell CRISPR screens are powerful tools to understand genome function by linking genetic perturbations to transcriptome-wide phenotypes.
Yihan Wang +3 more
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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Nature Communications, 2018 Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
Terrence N. Wong +21 more
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Clonal expansion behind a marine diatom bloom [PDF]
The ISME Journal, 2017 Abstract Genetic diversity is what selection acts on, thus shaping the adaptive potential of populations. We studied micro-evolutionary patterns of the key planktonic diatom Pseudo-nitzschia multistriata at a long-term sampling site over 2 consecutive years by genotyping isolates with 22 microsatellite markers.
Maria Valeria Ruggiero +6 more
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Multicolor strategies for investigating clonal expansion and tissue plasticity [PDF]
Cellular and Molecular Life Sciences, 2022 AbstractUnderstanding the generation of complexity in living organisms requires the use of lineage tracing tools at a multicellular scale. In this review, we describe the different multicolor strategies focusing on mouse models expressing several fluorescent reporter proteins, generated by classical (MADM, Brainbow and its multiple derivatives) or ...
L. Dumas +3 more
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