Results 21 to 30 of about 3,725,865 (331)

Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality

EBioMedicine, 2022
Summary: Background: Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL ...
James J. Anderson, Ezra Susser, Konstantin G. Arbeev, Anatoliy I. Yashin, Daniel Levy, Simon Verhulst, Abraham Aviv   +6 more
doaj   +1 more source

Effect of antiviral treatment on hepatitis B virus integration and hepatocyte clonal expansion.

Clinical Infectious Diseases, 2022
BACKGROUND This study investigated the effect of nucleos(t)ide analogues (NUC) treatment on HBV DNA integration and hepatocyte clonal expansion, both of which are implicated in hepatocellular carcinoma (HCC) in chronic hepatitis B. METHODS Twenty-eight
Ning Chow, D. Wong, Ching-Lung Lai, Lung-Yi Mak, James Fung, Hoi-Tang Ma, Mengyang Lei, W. Seto, Man-Fung Yuen   +8 more
semanticscholar   +1 more source

Bayesian Inference of Clonal Expansions in a Dated Phylogeny [PDF]

Systematic Biology, 2021
Abstract Microbial population genetics models often assume that all lineages are constrained by the same population size dynamics over time. However, many neutral and selective events can invalidate this assumption and can contribute to the clonal expansion of a specific lineage relative to the rest of the population.
David Helekal, Alice Ledda, Erik Volz, David Wyllie, Xavier Didelot   +4 more
openaire   +3 more sources

Aberrant activation of TCL1A promotes stem cell expansion in clonal hematopoiesis

Nature, 2023
Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.
J. Weinstock, J. Gopakumar, B. Burugula, M. Uddin, N. Jahn, Julia A. Belk, Hind Bouzid, B. Daniel, Zhuang Miao, Nghi Ly, T. Mack, Sofia E. Luna, Katherine Prothro, Shaneice R. Mitchell, C. Laurie, J. Broome, K. Taylor, Xiu-Qing Guo, Moritz F. Sinner, Aenne S. von Falkenhausen, S. Kääb, A. Shuldiner, J. O'Connell, J. Lewis, E. Boerwinkle, K. Barnes, Nathalie Chami, E. Kenny, R. Loos, M. Fornage, L. Hou, D. Lloyd-Jones, S. Redline, B. Cade, B. Psaty, J. Bis, J. Brody, E. Silverman, J. Yun, D. Qiao, N. Palmer, B. Freedman, D. Bowden, M. Cho, D. DeMeo, R. Vasan, L. Yanek, L. Becker, S. Kardia, P. Peyser, Jiang He, M. Rienstra, P. van der Harst, R. Kaplan, S. Heckbert, N. Smith, K. Wiggins, D. Arnett, M. Irvin, H. Tiwari, M. Cutler, Stacey Knight, J. Muhlestein, A. Correa, L. Raffield, Yan Gao, M. de Andrade, J. Rotter, S. Rich, R. Tracy, B. Konkle, J. Johnsen, M. Wheeler, J. G. Smith, O. Melander, P. M. Nilsson, B. Custer, R. Duggirala, J. Curran, J. Blangero, S. McGarvey, L. Williams, S. Xiao, Mao Yang, C. Gu, Y. Chen, Wen-Jane Lee, G. Marcus, J. Kane, C. Pullinger, M. Shoemaker, D. Darbar, D. Roden, Christine M. Albert, C. Kooperberg, Ying-Xiao Zhou, J. Manson, P. Desai, Andrew D. Johnson, R. Mathias, T. Blackwell, G. Abecasis, A. Smith, H. M. Kang, Ansuman T. Satpathy, P. Natarajan, J. Kitzman, E. Whitsel, A. Reiner, A. Bick, Siddhartha Jaiswal   +110 more
semanticscholar   +1 more source

Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients

Nature Cancer, 2021
Low-affinity CD19 chimeric antigen receptor (CAR) T cells display enhanced expansion and persistence, enabling fate tracking through integration site analysis.
L. Biasco, N. Izotova, C. Rivat, S. Ghorashian, R. Richardson, A. Guvenel, R. Hough, R. Wynn, B. Popova, Andre Lopes, M. Pule, A. Thrasher, P. Amrolia   +12 more
semanticscholar   +1 more source

‘Emerging concepts of vascular cell clonal expansion in atherosclerosis’

Arteriosclerosis, Thrombosis and Vascular Biology, 2022
Clonal expansion is a process that can drive pathogenesis in human diseases, with atherosclerosis being a prominent example. Despite advances in understanding the etiology of atherosclerosis, clonality studies of vascular cells remain in an early stage ...
A. Misra, Rajan Rehan, A. Lin, Sanjay Patel, E. Fisher   +4 more
semanticscholar   +1 more source

Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization

Circulation Research, 2018
Rationale: Vascularization is critical to maintain organ function. Although many molecular pathways were shown to control vessel growth, the genuine process of capillary formation under different ...
Yosif Manavski, T. Lucas, S. Glaser, Lena Dorsheimer, S. Günther, T. Braun, M. Rieger, A. Zeiher, R. Boon, S. Dimmeler   +9 more
semanticscholar   +2 more sources

Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer

Nature Cancer, 2021
Anti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood.
Baolin Liu, Xue-Da Hu, K. Feng, Ran-Ran Gao, Zhi-Qiang Xue, Su-jie Zhang, Yuan-Yuan Zhang, Emily Corse, Yi Hu, Wei-Dong Han, Ze-Min Zhang   +10 more
semanticscholar   +1 more source

Genetic instability and clonal expansion [PDF]

Journal of Theoretical Biology, 2006
Inactivation of tumor suppressor genes can lead to clonal expansion. We study the evolutionary dynamics of this process and calculate the probability that inactivation of a tumor suppressor gene is preceded by mutations in genes that confer genetic instability.
Nowak, Martin A., Michor, Franziska, Iwasa, Yoh   +2 more
openaire   +2 more sources

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Nature Medicine, 2020
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana, E. Legrand, Barbara H. Stokes, J. Ndikumana, M. Warsame, Noella Umulisa, D. Ngamije, Tharcisse Munyaneza, J. Mazarati, Kaendi J. Munguti, P. Campagne, A. Criscuolo, F. Ariey, Monique Murindahabi, P. Ringwald, D. Fidock, A. Mbituyumuremyi, D. Ménard   +17 more
semanticscholar   +1 more source