Results 11 to 20 of about 3,725,865 (331)

Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model [PDF]

Scientific Reports, 2017
Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals.
Yorifumi Satou, Hiroo Katsuya, Asami Fukuda, Naoko Misawa, Jumpei Ito, Yoshikazu Uchiyama, Paola Miyazato, Saiful Islam, Ariberto Fassati, Anat Melamed, Charles R. M. Bangham, Yoshio Koyanagi, Kei Sato   +12 more
doaj   +3 more sources

Dynamics of latent HIV under clonal expansion.

PLoS Pathogens, 2021
The HIV latent reservoir exhibits slow decay on antiretroviral therapy (ART), impacted by homeostatic proliferation and activation. How these processes contribute to the total dynamic while also producing the observed profile of sampled latent clone ...
John M Murray
doaj   +4 more sources

Sediment availability provokes a shift from Brownian to Lévy‐like clonal expansion in a dune building grass [PDF]

Ecology Letters, 2020
In biogeomorphic landscapes, plant traits can steer landscape development through plant‐mediated feedback interactions. Interspecific differences in clonal expansion strategy can therefore lead to the emergence of different landscape organisations.
V. Reijers, S. Hoeks, J. van Belzen, Koen Siteur, A. J. A. de Rond, Clea N. van de Ven, C. Lammers, J. van de Koppel, T. van der Heide   +8 more
semanticscholar   +2 more sources

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

Cell Reports, 2018
Endometriosis is characterized by ectopic endometrial-like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples isolated by ...
Kosuke Yoshihara, Kazuaki Suda, Tatsuya Ishiguro   +2 more
exaly   +2 more sources

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells [PDF]

Genome Biology
Background Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues.
Xin Wang, Kun Wang, Weixing Zhang, Zhongjie Tang, Hao Zhang, Yuying Cheng, Da Zhou, Chao Zhang, Wen-Zhao Zhong, Qing Ma, Jin Xu, Zheng Hu   +11 more
doaj   +2 more sources

Clonal Expansion

Definitions, 2020

semanticscholar   +2 more sources

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth

Nature Genetics, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this hypothesis.
E. Abby, S. Dentro, M. N. Hall, Joanna C. Fowler, S. Ong, R. Sood, A. Herms, G. Piedrafita, I. Abnizova, C. Siebel, M. Gerstung, B. A. Hall, P. Jones   +12 more
semanticscholar   +1 more source

Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling.

Cell Reports, 2023
Microglia arise from the yolk sac and enter the brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation and eventually colonize the entire brain by the third postnatal week in mice.
L. Barry-Carroll, P. Greulich, Abigail R. Marshall, K. Riecken, B. Fehse, Katharine E. Askew, Kai-Zhen Li, O. Garaschuk, D. Menassa, D. Gomez-Nicola   +9 more
semanticscholar   +1 more source

Clonal Expansion in Cardiovascular Pathology [PDF]

, 2023
Clonal expansion refers to the proliferation and selection of advantageous ‘clones’ that are better suited for survival in a Darwinian manner. In recent years we have greatly enhanced our understanding of cell clonality in the cardiovascular context ...
Fisher, Edward A, Brittan, Mairi, Misra, Ashish, Dimmeler, Stefanie, Lin, Alexander, Baker, Andrew H, Sluimer, Judith   +6 more
core   +1 more source

Using DNA methylation patterns to infer tumor ancestry. [PDF]

PLoS ONE, 2010
Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells.
You Jin Hong, Paul Marjoram, Darryl Shibata, Kimberly D Siegmund   +3 more
doaj   +1 more source