Results 11 to 20 of about 107,781 (288)

Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model [PDF]

Scientific Reports, 2017
Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals.
Yorifumi Satou, Hiroo Katsuya, Asami Fukuda, Naoko Misawa, Jumpei Ito, Yoshikazu Uchiyama, Paola Miyazato, Saiful Islam, Ariberto Fassati, Anat Melamed, Charles R. M. Bangham, Yoshio Koyanagi, Kei Sato   +12 more
doaj   +2 more sources

Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis. [PDF]

JCI Insight
Clonal hematopoiesis of indeterminate potential (CHIP) is the expansion of blood stem cells and progeny after somatic mutation. CHIP associates with increased cardiovascular disease (CVD), with inflammation from macrophages a proposed common effector ...
Carter PR, Kitt L, Rodgers AC, Figg N, Zhou A, Zhu C, Wang Z, Libby P, Burgess S, Vassiliou GS, Clarke MC.   +10 more
europepmc   +2 more sources

Clonal Expansion in Cardiovascular Pathology [PDF]

, 2023
Clonal expansion refers to the proliferation and selection of advantageous ‘clones’ that are better suited for survival in a Darwinian manner. In recent years we have greatly enhanced our understanding of cell clonality in the cardiovascular context ...
Fisher, Edward A, Brittan, Mairi, Misra, Ashish, Dimmeler, Stefanie, Lin, Alexander, Baker, Andrew H, Sluimer, Judith   +6 more
core   +1 more source

Genetic instability and clonal expansion [PDF]

Journal of Theoretical Biology, 2006
Inactivation of tumor suppressor genes can lead to clonal expansion. We study the evolutionary dynamics of this process and calculate the probability that inactivation of a tumor suppressor gene is preceded by mutations in genes that confer genetic instability.
Nowak, Martin A., Michor, Franziska, Iwasa, Yoh   +2 more
openaire   +2 more sources

A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

iScience, 2023
Summary: Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection.
Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A.A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas   +18 more
doaj   +1 more source

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +1 more source

Evolution of Resistance During Clonal Expansion [PDF]

Genetics, 2006
Abstract Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells.
Yoh, Iwasa, Martin A, Nowak, Franziska, Michor   +2 more
openaire   +2 more sources

Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine [PDF]

, 2013
Streptococcus pneumoniae causes invasive infections, primarily at the extremes of life. A seven-valent conjugate vaccine (PCV7) is used to protect against invasive pneumococcal disease in children.
Nicholas J Loman, Jacqueline Chan, Tocheva Anna S., O’Connor Leigh, Pallen, Mark J., Constantinidou C., Loman, Nicholas J., Pallen M.J., Faust, Saul N, Faust, Saul N., Loman, Nicholas, Clarke S.C., Tocheva A.S., Constantinidou Chrystala, Mark J Pallen, Loman, Nicholas J, Chan, Jacqueline, Constantinidou, Chrystala, Stuart C Clarke, Pallen, Mark J, Gladstone R.A., O'Connor, Leigh, Chrystala Constantinidou, Clarke, Stuart C, Tocheva, Anna S., Faust, S.N., Clarke, S.C., Johanna M C Jefferies, Loman Nicholas J., Faust Saul N., Clarke Stuart C., Gladstone, Rebecca A., Chan J., O’Connor, Leigh, Leigh O'Connor, Anna S Tocheva, Clarke, Stuart C., Pallen, Mark, Tocheva, Anna S, Jefferies J.M.C., Jefferies, Johanna M C, Loman N.J., Chan Jacqueline, Jefferies, Johanna M.C., Gladstone, Rebecca, Saul N Faust, Jefferies Johanna M. C., Jefferies, Johanna M. C., Faust S.N., Pallen Mark J., Gladstone, Rebecca A, Rebecca A Gladstone, O'Connor L., Gladstone Rebecca A.   +53 more
core   +1 more source

Novel synthetic monoketone transmute radiation-triggered NFκB-dependent TNFα cross-signaling feedback maintained NFκB and favors neuroblastoma regression. [PDF]

PLoS ONE, 2013
Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion.
Sheeja Aravindan, Mohan Natarajan, Vibhudutta Awasthi, Terence S Herman, Natarajan Aravindan   +4 more
doaj   +1 more source

The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells [PDF]

, 2007
We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells.
MacDonald, Andrew, Mahajan, Simmi, Fillatreau, Simon, Cervera, Ana, MacDonald, Andrew; id_orcid, Smith, Andrew, Gray, David, Ana Cervera, Perona-Wright, Georgia, Macleod, Megan, Andrew Smith, Stephen Meek, Megan MacLeod, Andrew MacDonald, Meek, Stephen, Simmi Mahajan, David Gray, Georgia Perona‐Wright, Simon Fillatreau   +18 more
core   +1 more source