Results 41 to 50 of about 3,725,865 (331)

mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

iScience, 2023
Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster.
Ellie N. Ivanova, Jasmine Shwetar, Joseph C. Devlin, Terkild B. Buus, Sophie Gray-Gaillard, Akiko Koide, Amber Cornelius, Marie I. Samanovic, Alberto Herrera, Eleni P. Mimitou, Chenzhen Zhang, Trishala Karmacharya, Ludovic Desvignes, Niels Ødum, Peter Smibert, Robert J. Ulrich, Mark J. Mulligan, Shohei Koide, Kelly V. Ruggles, Ramin S. Herati, Sergei B. Koralov   +20 more
doaj   +1 more source

Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)

Experimental Hematology & Oncology, 2019
Background Large clonal populations of cells bearing PIG-A mutations are the sine qua non of PNH, but the PIG-A mutation itself is insufficient for clonal expansion.
Camille Lobry, Ashish Bains, Leah B. Zamechek, Sherif Ibrahim, Iannis Aifantis, David J. Araten   +5 more
doaj   +1 more source

Effects of Cu Pollution on the Expansion of an Amphibious Clonal Herb in Aquatic-Terrestrial Ecotones. [PDF]

PLoS ONE, 2016
Physiological integration can enhance the performance of clonal plants in aquatic and terrestrial heterogeneous habitats and associated ecotones. Similar to nutrients, pollutants may be transported among connected ramets via physiological integration ...
Liang Xu, Zhen-Feng Zhou
doaj   +1 more source

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Nature Communications, 2018
Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
Terrence N. Wong, Christopher A. Miller, Matthew R. M. Jotte, Nusayba Bagegni, Jack D. Baty, Amy P. Schmidt, Amanda F. Cashen, Eric J. Duncavage, Nichole M. Helton, Mark Fiala, Robert S. Fulton, Sharon E. Heath, Megan Janke, Kierstin Luber, Peter Westervelt, Ravi Vij, John F. DiPersio, John S. Welch, Timothy A. Graubert, Matthew J. Walter, Timothy J. Ley, Daniel C. Link   +21 more
doaj   +1 more source

Computational identification of clonal cells in single-cell CRISPR screens

BMC Genomics, 2022
Background Single-cell CRISPR screens are powerful tools to understand genome function by linking genetic perturbations to transcriptome-wide phenotypes.
Yihan Wang, Shiqi Xie, Daniel Armendariz, Gary C. Hon   +3 more
doaj   +1 more source

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Science, 2019
Somatic mosaicism in normal tissues Somatic cells can accumulate mutations over the course of an individual's lifetime. This generates cells that differ genetically at specific loci within the genome.
K. Yizhak, F. Aguet, Jaegil Kim, J. Hess, Kirsten Kübler, J. Grimsby, Ruslana Frazer, Hai-Lei Zhang, N. Haradhvala, D. Rosebrock, D. Livitz, Xiao Li, Eila Arich-Landkof, N. Shoresh, Chip Stewart, Ayelet Segre, P. Branton, P. Polak, K. Ardlie, G. Getz   +19 more
semanticscholar   +1 more source

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Nature Communications, 2020
HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) are capable of secreting high antibody titers.
A. Nahmad, Y. Raviv, M. Horovitz-Fried, Ilan Sofer, Tal Akriv, D. Nataf, I. Dotan, Y. Carmi, D. Burstein, Y. Wine, I. Benhar, A. Barzel   +11 more
semanticscholar   +1 more source

Developmentally Programmed Division of Labor in the Aquatic Invader Alternanthera philoxeroides Under Homogeneous Soil Nutrients

Frontiers in Plant Science, 2019
Clonal traits can contribute to plant invasiveness, but little is known about the roles of division of labor (a key clonal trait) in homogeneous habitats. The hypothesis tested is that clonal integration allows division of labor and increases the overall
Dao-Guo Xi, Wen-Hua You, An-An Hu, Ping Huang, Dao-Lin Du   +4 more
doaj   +1 more source

Flower-deficient mice have reduced susceptibility to skin papilloma formation

Disease Models & Mechanisms, 2012
SUMMARY Skin papillomas arise as a result of clonal expansion of mutant cells. It has been proposed that the expansion of pretumoral cell clones is propelled not only by the increased proliferation capacity of mutant cells, but also by active cell ...
Evgeniya Petrova, Jesús M. López-Gay, Christa Rhiner, Eduardo Moreno   +3 more
doaj   +1 more source

The evolution of tumor metastases during clonal expansion [PDF]

Journal of Theoretical Biology, 2010
Cancer is a leading cause of morbidity and mortality in many countries. Solid tumors generally initiate at one particular site called the primary tumor, but eventually disseminate and form new colonies in other organs. The development of such metastases greatly diminishes the potential for a cure of patients and is thought to represent the final stage ...
Haeno, Hiroshi, Michor, Franziska
openaire   +3 more sources