Results 51 to 60 of about 3,725,865 (331)

Clonal Expansion of Verticillium dahliae in Lettuce [PDF]

Phytopathology®, 2014
Few studies in population biology have documented how structure and diversity of pathogens evolve over time at local scales. With the historical samples of Verticillium dahliae available from lettuce, we investigated the structure and diversity of this pathogen in time and space. Three hundred twenty-nine V.
S, Gurung, D P G, Short, Z K, Atallah, K V, Subbarao   +3 more
openaire   +2 more sources

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

Nature Communications, 2019
After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues to decline slowly.
M. Pinzone, D. J. VanBelzen, S. Weissman, M. Bertuccio, L. Cannon, E. Venanzi-Rullo, S. Migueles, R. B. Jones, T. Mota, Sarah B. Joseph, K. Groen, A. Pasternak, W. Hwang, B. Sherman, Anastasios Vourekas, G. Nunnari, U. O'Doherty   +16 more
semanticscholar   +1 more source

Clonal expansion of T-cells in measles

Immunology Letters, 1998
Some autoimmune complications such as postinfectious encephalomyelitis are associated with immunologic abnormalities induced by measles virus infection. To address the superantigenic stimulation in measles which might be related with autoimmune complications, T-cells bearing the TCRBV5S2 or TCRBV8 chains and the expression of activation markers were ...
Chwae, YJ, Choi, IH, Kim, DS, Shin, EC Shin, Eui-Cheol, Kwon, DH, Kim, SJ, Kim, JD   +6 more
openaire   +3 more sources

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia

Haematologica, 2023
Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL).
Edwin Quinten, Julieta H. Sepúlveda-Yáñez, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Valeri Nteleah, Ruben A.L. de Groen, Diego Alvarez Saravia, Jeroen Knijnenburg, Hedwig E. Stuivenberg-Bleijswijk, Milena Pantic, Andreas Agathangelidis, Andrea Keppler-Hafkemeyer, Cornelis A. M. van Bergen, Roberto Uribe-Paredes, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo A. Navarrete, Hassan Jumaa, Hendrik Veelken   +20 more
doaj   +1 more source

The Evolution of Two Mutations During Clonal Expansion [PDF]

Genetics, 2007
Abstract Knudson's two-hit hypothesis proposes that two genetic changes in the RB1 gene are the rate-limiting steps of retinoblastoma. In the inherited form of this childhood eye cancer, only one mutation emerges during somatic cell divisions while in sporadic cases, both alleles of RB1 are inactivated in the growing retina.
Hiroshi, Haeno, Yoh, Iwasa, Franziska, Michor   +2 more
openaire   +2 more sources

JunB Is Critical for Survival of T Helper Cells

Frontiers in Immunology, 2022
Clonal expansion and differentiation of various T helper subsets, such as Th1, Th2, and Th17 cells, depend on a complex of transcription factors, IRF4 and a BATF-containing AP-1 heterodimer.
Tsunghan Hsieh, Daiki Sasaki, Naoyuki Taira, Hsiaochiao Chien, Shukla Sarkar, Yu Seto, Mio Miyagi, Hiroki Ishikawa   +7 more
doaj   +1 more source

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Nature Communications, 2019
Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to loss-of-function mutations to any one of three CCM genes.
M. Malinverno, Claudio Maderna, Abdallah Abu Taha, M. Corada, F. Orsenigo, Mariaelena Valentino, F. Pisati, C. Fusco, P. Graziano, Monica Giannotta, Q. Yu, Y. Zeng, M. Lampugnani, P. Magnusson, E. Dejana   +14 more
semanticscholar   +1 more source

Schematic of a general multistage clonal expansion model.

, 2017
Multistage clonal expansion models are continuous-time Markov chain models in which normal cells undergo a series of genetic changes that lead to a state of clonal expansion followed by progression to malignancy.
Rafael Meza (201050), Marisa C. Eisenberg (749700), Andrew F. Brouwer (2558998)   +2 more
core   +1 more source

Genetic Variation in Spatio-Temporal Confined USA300 Community-Associated MRSA Isolates: A Shift from Clonal Dispersion to Genetic Evolution? [PDF]

, 2011
NTRODUCTION: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly isolated, with USA300-0114 being the predominant clone in the USA. Comparative whole genome sequencing of USA300 isolates collected in 2002, 2003 and
Fluit, AC, Bonten Marc J. M., Thomas W. Rice, Bonten, MJ, Jodi A. Lindsay, Rob J. L. Willems, Adam A. Witney, Rice, TW, Lindsay Jodi A., Carpaij Neeltje, Weinstein, RA, Hinds Jason, Marc J. M. Bonten, Robert A. Weinstein, Witney Adam A., Witney, AA, Weinstein Robert A., Ad C. Fluit, Carpaij, N, Willems, RJ, Lindsay, JA, Hinds, J, Fluit Ad C., Jason Hinds, Neeltje Carpaij, Rice Thomas W., Willems Rob J. L.   +26 more
core   +1 more source

Longitudinal characterization of mosaic chromosomal alterations identifies factors influencing clonal dynamics of leukocytes

Nature Communications
Characterizing the variation in clonal trajectory of age-related mosaic chromosomal alterations (mCAs) in circulating leukocytes can identify etiologic factors influencing clonal expansion and hematologic malignancy risk. Here we scan whole blood-derived
Rebecca L. Kelly, Derek W. Brown, Weiyin Zhou, Aubrey K. Hubbard, Corey D. Young, Kara M. Barnao, Alyssa Klein, Diptavo Dutta, Aurélie Vogt, Jia Liu, Jiahui Wang, Wen-Yi Huang, Neal D. Freedman, Stephen J. Chanock, Paul S. Albert, Mitchell J. Machiela   +15 more
doaj   +1 more source