Results 51 to 60 of about 107,781 (288)
Targeting the clonal expansion of mitochondrial DNA mutations in ageing and disease [PDF]
, 2022 Ph. D. Thesis.The clonal expansion of mitochondrial DNA (mtDNA) mutations is believed to mediate the presentation and severity of clinical symptoms of a wide range of inherited and age-related diseases.
McNiff, Megan
core
Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
Nature Communications, 2018 Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a
Pierre Martinez +8 more
doaj +1 more source
Frontiers in Environmental Science, 2023 Soil salinity is well known heterogeneous and various within natural soil environment. In Songnen grassland of Northeast China, grazing aggravates the saline-alkali heterogeneity in soil habitat, which led to dominant clonal plant species forming a ...
Luhao Qu +9 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization
, 2018 Rationale: Vascularization is critical to maintain organ function. Although many molecular pathways were shown to control vessel growth, the genuine process of capillary formation under different ...
Michael A. Rieger +29 more
core +1 more source
PLoS ONE, 2019 Current methods to quantify T-cell clonal expansion only account for variance due to random sampling from a highly diverse repertoire space. We propose a beta-binomial model to incorporate time-dependent variance into the assessment of differentially ...
Julie Rytlewski +6 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
, 2011 NTRODUCTION: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly isolated, with USA300-0114 being the predominant clone in the USA. Comparative whole genome sequencing of USA300 isolates collected in 2002, 2003 and
Fluit, AC +26 more
core +1 more source
Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment. [PDF]
Cancer is an evolutionary process characterized by profound intratumor heterogeneity (ITH), which can be quantified using in silico estimates of cancer cell fractions (CCFs) of tumor-specific somatic mutations. We demonstrate a data-driven approach based
Ke Yuan (172453) +6 more
core +2 more sources
Protocol for monitoring clonal hematopoiesis in transgenic mouse models using multispectral imaging
STAR ProtocolsSummary: Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate ...
Priyanka Khanna +5 more
doaj +1 more source