Results 71 to 80 of about 107,781 (288)
Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific
, 1998 Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS +22 more
core +1 more source
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions
Nature CommunicationsEffective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. However, our insights into clonal expansions are limited, owing to an inability to track the same clones in tumors over time. Here, we develop a
Munetomo Takahashi +10 more
doaj +1 more source
Frontiers in ImmunologyIntroductionHematopoietic stem cell transplantation is a potentially curative intervention for a broad range of diseases. However, there is evidence that malignant or pre-malignant clones contained in the transplant can expand in the recipient and ...
Thomas Stiehl, Thomas Stiehl
doaj +1 more source
PLoS Pathogens, 2019 Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if there is
Andrea L Ferris +8 more
doaj +1 more source
Somatic mutation and clonal expansions in human tissues [PDF]
Genome Medicine, 2019 Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases.
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2021 This dataset contains i) the clonal expansion traits of three marsh species (Spartina anglica, Scirpus maritimus, and Phragmites australis) at marsh edges in a series of mesocosm experiments; and ii) cliff formation at mimicked marsh edges (S.
Haobing Cao (11108265)
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
, 2010 The classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling ...
core +1 more source
, 2021 International audienceToxic epidermal necrolysis (TEN) is a life-threatening cutaneous adverse drug reaction. To better understand why skin symptoms are so severe, we conducted a prospective immunophenotyping study on skin and blood.
Villani, Axel Patrice +52 more
core +1 more source