Results 91 to 100 of about 3,725,865 (331)
Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming
Immunity, 2017 &NA; Store‐operated Ca2+ entry (SOCE) is the main Ca2+ influx pathway in lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by Ca2+ release‐activated Ca2+ (CRAC) channels that are activated by stromal interaction ...
M. Vaeth +11 more
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2019 SIV integration sites in genes where integration has been linked to clonal expansion in an HIV-infected patient.
Stephen H. Hughes (642641) +8 more
core +1 more source
npj Breast CancerPatients with germline pathogenic variants of BRCA1/2 genes have a particular predisposition to develop breast cancer. No clinical test has been developed to accurately and quantitatively evaluate their risk of developing breast cancer.
Takeshi Hirose +12 more
doaj +1 more source
Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium
Nature Communications, 2022 Through regeneration, the endometrium accumulates somatic mutations that can lead to diseases like endometriosis and cancer. Here, the authors use genomics to analyse normal endometrial glands from different patient cohorts, detect rhizome structures ...
Manako Yamaguchi +17 more
doaj +1 more source
Nature Communications, 2019 Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. However, it remains unclear how MSI and hypermutation arise and contribute to cancer development.
Yusuke Matsuno +14 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions
Nature CommunicationsEffective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. However, our insights into clonal expansions are limited, owing to an inability to track the same clones in tumors over time. Here, we develop a
Munetomo Takahashi +10 more
doaj +1 more source
Frontiers in ImmunologyIntroductionHematopoietic stem cell transplantation is a potentially curative intervention for a broad range of diseases. However, there is evidence that malignant or pre-malignant clones contained in the transplant can expand in the recipient and ...
Thomas Stiehl, Thomas Stiehl
doaj +1 more source
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
Nature Communications, 2019 Field cancerization is a premalignant process marked by clones of oncogenic mutations spreading through the epithelium. The timescales of intestinal field cancerization can be variable and the mechanisms driving the rapid spread of oncogenic clones are ...
Peter G. Boone +16 more
semanticscholar +1 more source