Results 111 to 120 of about 107,781 (288)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Clonal expansion in a context of normal chromosome mis-segregation.

, 2013
(A) Evaluation of clonal expansion of cells with trisomy for a single chromosome (+C), set up under similar conditions as described in Figure 8 but with a mis-segregation rate similar to normal fibroblasts (p = 4×10−4), a constant rate of positive ...
David Gisselsson (23248), Yuesheng Jin (23245), Anders Valind (436802)   +2 more
core   +1 more source

Description of a possible clonal expansion of Plasmodium vivax in Manaus - Amazonas - Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 1999
Atypical P. vivax cases reported in Manaus municipality led us to detect a genetic isolate of P. vivax. Variable regions of SSUrRNA were examined from the initial time of infection and in the two recrudescences/relapses from a patient exhibiting ...
Maria das Graças Costa Alecrim, Wilson Duarte Alecrim, Vanize Macêdo, Caroline T. Korves, Donald R. Roberts, Jun Li, Margery Sullivan, Thomas F. McCutchan   +7 more
doaj  

Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques

Frontiers in Immunology, 2019
Recent functional, gene expression, and epigenetic studies have suggested the presence of a subset of mature natural killer (NK) cells responsible for maintaining NK cell memory. The lack of endogenous clonal markers in NK cells impedes understanding the
Lauren L. Truitt, Di Yang, Di Yang, Diego A. Espinoza, Diego A. Espinoza, Xing Fan, Daniel R. Ram, Matilda J. Moström, Dollnovan Tran, Lesli M. Sprehe, R. Keith Reeves, R. Keith Reeves, Robert E. Donahue, Amitinder Kaur, Cynthia E. Dunbar, Chuanfeng Wu   +15 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Investigating the mechanism of clonal expansion of deleted mtDNA species [PDF]

, 2014
PhD ThesisMitochondrial DNA deletions are a primary cause of inherited and sporadic mitochondrial disease, whilst somatic mtDNA deletions contribute to the focal respiratory chain deficiency observed in post-mitotic cells associated with ageing and
Campbell, Georgia Elizabeth
core  

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

clonal expansion

Citation: 'clonal expansion' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13014 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source