Results 111 to 120 of about 3,725,865 (331)
Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance T cells are a central component of our immune system. They express a T cell receptor (TCR) on their surface, which detects pathogens and stimulates the T cell to initiate an immune response. Upon exposure to a specific pathogen, some T cells
Huang Huang +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
JCI Insight, 2017 Fibrous cap smooth muscle cells (SMCs) protect atherosclerotic lesions from rupturing and causing thrombosis, while other plaque SMCs may have detrimental roles in plaque development.
Kevin Jacobsen +7 more
semanticscholar +1 more source
Somatic mutation and clonal expansions in human tissues [PDF]
Genome Medicine, 2019 Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases.
openaire +3 more sources
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
The role of integration and clonal expansion in HIV infection: live long and prosper
Retrovirology, 2018 Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, F. Maldarelli
semanticscholar +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Distinct genomic characteristics between embryonic and clonal expansion pSNMs.
, 2018 (A-C) Mutation spectrums in NpG and non-NpG sites for embryonic pSNMs (A), clonal expansion pSNMs in BBLD1005’s liver (B), and clonal expansion pSNMs in BBL11121’s breast (C). Mutation rate was normalized by the total number of sites in the human genome.
Qixi Wu (5220827) +6 more
core +1 more source
Emerging Infectious Diseases, 2009 Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug–resistance ...
Mary G. Krauland +3 more
doaj +1 more source
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury
Nature Communications, 2018 The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart.
Konstantina-Ioanna Sereti +17 more
semanticscholar +1 more source