Results 131 to 140 of about 3,725,865 (331)
Clonal Expansion without Self-replicating Entities [PDF]
, 2012 The vertebrate immune system is a complex distributed system capable of learning to tolerate the organisms' tissues, to assimilate a diverse commensal microflora, and to mount specific responses to invading pathogens. These intricate functions are performed almost flawlessly by a self-organised collective of cells.
Danesh Tarapore +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
, 2008 Clonal CD27+ CD19+ B-Cell Expansion through Inhibition of FCgIIR in HCV+ Lymphorpoliferative ...
Sansonno S +4 more
core
Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis
Science immunology, 2018 T cell responses to subunit vaccination require both IL-27 and IL-15 to support an aerobic glycolysis–independent metabolic program. Mitochondria fuel vaccine-induced T cells Effective T cell responses to subunit vaccines administered with an adjuvant ...
J. Klarquist +12 more
semanticscholar +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Cancer is an evolutionary process characterized by profound intratumor heterogeneity (ITH), which can be quantified using in silico estimates of cancer cell fractions (CCFs) of tumor-specific somatic mutations. We demonstrate a data-driven approach based
Ke Yuan (172453) +6 more
core +2 more sources
The Impact of Splicing Factor Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Progression
Frontiers in Bioscience-LandmarkClonal hematopoiesis (CH) is characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, which confers an increased risk of hematologic malignancies and cardiovascular disease.
Takuya Izumi-Tamura +2 more
doaj +1 more source
T-cell localization, activation, and clonal expansion in human pancreatic ductal adenocarcinoma
Cancer immunology research, 2017 Pancreatic ductal adenocarcinoma resists immune checkpoint blockade. The nature and localization of endogenous CD8+ T cells and suppressive cells infiltrating human pancreatic ductal adenocarcinoma were examined, providing a basis for the design of more ...
Ingunn M. Stromnes +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells
bioRxiv, 2018 Rationale Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations.
Matthew R. Detter +2 more
semanticscholar +1 more source