Results 121 to 130 of about 3,725,865 (331)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Mmp10 is required for clonal expansion of CMT167 oncospheres.

, 2012
A) Photomicrographs of clonal expansion of single NT and Mmp10 RNAi CMT167 oncosphere cells in the presence or absence or recombinant Mmp10. B) Colony diameter derived from single CMT167 NT and Mmp10 RNAi cells.
Roderick P. Regala (168909), Michael P. Walsh (168911), Nicole R. Murray (168913), Jyotica Batra (119607), Evette S. Radisky (119634), Alan P. Fields (168917), Verline Justilien (168908), I-Chu Tseng (168910)   +7 more
core   +1 more source

Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?

Case Reports in Hematology, 2013
Second cancers and particularly postransplant lymphoproliferative disorders (PTLDs) are extremely rare in patients undergoing autologous peripheral blood stem cell transplantation (auto-SCT).
Giuseppe Mele, Marilena Greco, Maria Rosaria Coppi, Giacomo Loseto, Angela Melpignano, Salvatore Mauro, Gianni Quarta   +6 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Clonal Expansion from Standing Genetic Variation Underpins the Evolution of Curtobacterium flaccumfaciens pv. flaccumfaciens in Australia

Pathogens can evolve rapidly, leading to the emergence of novel strains that can overcome commercially deployed host plant resistance. Understanding the genetic and phenotypic diversity and population dynamics of plant pathogens is crucial to inform ...
Kelly, Lisa A., Sparks, Adam H., Vaghefi, Niloofar, Adorada, Dante L., Knight, Noel L., Colombi, Elena, Young, Anthony, Department of Primary Industries, Queensland   +7 more
core   +1 more source

Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development

Cell Reports, 2017
Antibody repertoire diversity and plasticity is crucial for broad protective immunity. Repertoires change in size and diversity across multiple B cell developmental stages and in response to antigen exposure.
Victor Greiff, Ulrike Menzel, Enkelejda Miho, Cédric Weber, René Riedel, Skylar Cook, Atijeh Valai, Telma Lopes, Andreas Radbruch, Thomas H. Winkler, Sai T. Reddy   +10 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Clonal competition within complex evolutionary hierarchies shapes AML over time

, 2020
Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition
Lilljebjörn, Henrik, Thorsson, Hanna, Rissler, Marianne, Landberg, Niklas, Högberg, Carl, Lazarevic, Vladimir, Sandén, Carl, von Palffy, Sofia, Fioretos, Thoas, Peña-Martinez, Pablo, Ågerstam, Helena, Henningsson, Rasmus, Orsmark Pietras, Christina, Saba, Karim H., Gisselsson, David, Juliusson, Gunnar, Thorsson, Hanna,, Sandén, Carl,, Saba, Karim H.,, Gisselsson, David,, Högberg, Carl,, Juliusson, Gunnar,, Lazarevic, Vladimir,, Lilljebjörn, Henrik,, Orsmark Pietras, Christina,, von Palffy, Sofia,, Peña-Martinez, Pablo,, Henningsson, Rasmus,, Landberg, Niklas,, Rissler, Marianne,, Ågerstam, Helena,, Lund University., Fioretos, Thoas,   +32 more
core   +1 more source

siddhartha-kar/clonal-hematopoiesis: clonal hematopoiesis paper code repository

, 2022
This is the repository accompanying the pre-print titled, "Genome-wide analyses of 200,453 individuals yields new insights into the causes and consequences of clonal hematopoiesis" (https://www.medrxiv.org/content/10.1101/2022.01.06.22268846v1)
Siddhartha Kar
core   +1 more source

Long-term remission despite clonal expansion of replication-competent HIV-1 isolates.

JCI Insight, 2018
Clonal expansion of T cells harboring replication-competent virus has recently been demonstrated in patients on suppressive antiretroviral therapy (ART) regimens.
R. Veenhuis, Abena K. Kwaa, Caroline C. Garliss, R. Latanich, María Salgado, Christopher W. Pohlmeyer, Christopher L. Nobles, J. Gregg, E. Scully, J. Bailey, F. Bushman, J. Blankson   +11 more
semanticscholar   +1 more source