Results 101 to 110 of about 3,725,865 (331)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate

Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in hematopoietic stem cells confer a selective advantage and drive clonal expansion, not only correlates with age but also confers increased risk of morbidity and mortality.
Rich, Stephen S, Roden, Dan M, Raffield, Laura M, Pershad, Yash, Nachun, Daniel C, Redline, Susan, Manichaikul, Ani W, Lee, Wen-Jane, Carson, April P, Chen, Yii-Der Ida, Rotter, Jerome I, Smith, Nicholas L, Cade, Brian E, Mack, Taralynn M, Yun, Jeong H, Gu, C Charles, Wiggins, Kerri L, Psaty, Bruce M, Guo, Xiuqing, Yanek, Lisa R, Heckbert, Susan R, Blackwell, Thomas W, Kenny, Eimear E, Bick, Alexander G, Auer, Paul L, DeMeo, Dawn L, Kooperberg, Charles, Smith, Albert V, Weinstock, Joshua S, Mathias, Rasika A, Jaiswal, Siddhartha, Bis, Joshua C, Desai, Pinkal, Raddatz, Michael A, Taylor, Kent D, Cho, Michael H, O’Connell, Jeffrey R, Silverman, Edwin K, Levy, Daniel, Reiner, Alexander P, Brody, Jennifer A, Shoemaker, M Benjamin, Shuldiner, Alan R, Johnson, Andrew D, Loos, Ruth JF   +44 more
core   +1 more source

Clonal Expansion of Helper T Cells

, 2001
Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial.
Hutchins, Anne S., Reiner, Steven L., Anne S. Hutchins, Craig B. Thompson, Mullen, Alan C., Frances A. High, Lee, Hubert W., Alan C. Mullen, Hubert W. Lee, Thompson, Craig B., Villarino, Alejandro V., Alejandro V. Villarino, Steven L. Reiner, High, Frances A., Alden M. Doyle, Doyle, Alden M.   +15 more
core   +1 more source

Defining Clonal Color in Fluorescent Multi-Clonal Tracking [PDF]

, 2016
Clonal heterogeneity and selection underpin many biological processes including development and tumor progression. Combinatorial fluorescent protein expression in germline cells has proven its utility for tracking the formation and regeneration of ...
Runnels, Judith M., Lin, Charles, Alt, Clemens, Tsao, Hensin, Turcotte, Raphaël, Wu, Juwell   +5 more
core   +1 more source

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

Nature Communications, 2018
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a controlled infection of humans with live Salmonella enterica serovar Paratyphi A, that MAIT cells are
Lauren J. Howson, G. Napolitani, D. Shepherd, H. Ghadbane, Prathiba Kurupati, L. Preciado-Llanes, Margarida Rei, H. Dobinson, M. Gibani, K. Teng, E. Newell, N. Veerapen, G. Besra, A. Pollard, V. Cerundolo   +14 more
semanticscholar   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source