Results 81 to 90 of about 3,725,865 (331)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Protocol for monitoring clonal hematopoiesis in transgenic mouse models using multispectral imaging
STAR ProtocolsSummary: Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate ...
Priyanka Khanna +5 more
doaj +1 more source
Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
Nature Communications, 2018 Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a
Pierre Martinez +8 more
doaj +1 more source
Many colorectal cancers are “flat” clonal expansions [PDF]
Cell Cycle, 2009 Population geneticists can reconstruct the ancestries of macroscopic populations from polymorphisms in present day individuals. For example, the migration "out of Africa" is recorded in human genome variation in different parts of the world. Here we apply this approach to human colorectal cancer cell populations and polymorphic passenger methylation ...
Kimberly D, Siegmund +3 more
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Salient features of a multistage clonal expansion model hazard.
, 2017 Multistage clonal expansion models have exponential and linear phases that may be observed on the time scale of a human lifespan. Depending on the number of stages in the model, the asymptote may or may not occur within a human lifespan.
Rafael Meza (201050) +2 more
core +1 more source
The role of host environment in cancer evolution
Evolutionary Applications, 2020 Somatic mutations in oncogene and tumor suppressor genes accumulate in healthy tissues throughout life and delineate clones with limited expansion. Lifestyle‐related toxic insults increase the size and number of these clones that participate to tissue ...
Eric Solary, Lucie Laplane
doaj +1 more source
Molecular and Cellular Biology, 2018 Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear.
Masatoshi Kobayashi +17 more
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Biología de la expansión clonal
Iatreia, 2006 La expansión clonal-subclonal, tanto in vivo como in vitro, se caracteriza por la ventaja proliferativa de sub-poblaciones celulares subyacentes.
M. Soto, M. Camargo
doaj