Results 51 to 60 of about 30,642,264 (240)

Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]

, 2009
The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
core   +1 more source

HIV DNA reservoir and elevated PD‐1 expression of CD4 T‐cell subsets particularly persist in the terminal ileum of HIV‐positive patients despite cART

, 2021
International audienceDespite its importance as an HIV anatomic sanctuary, little is known about the characteristics of the HIV reservoir in the terminal ileum (TI).
V Bondet, MS Ercanoglu, D Nierhoff, Müller-Trutwin, M, Duffy, D, C Lehmann, E Knops, Knops, E, Bondet, V, M Augustin, J Anderson, Ercanoglu, Ms, Chon, S-H, Schäfer, H, H Schäfer, S‐H Chon, Held, K, M Müller‐Trutwin, C Horn, Oette, M, Rybniker, J, Geldmacher, C, Fätkenheuer, G, Klein, F, I Suárez, C Vivaldi, K Held, Heger, E, Anderson, J, J Rybniker, F Klein, Suárez, I, Horn, C, E Heger, Nierhoff, D, Lehmann, C, D Duffy, Augustin, M, Vivaldi, C, G Fätkenheuer, M Oette, C Geldmacher   +41 more
core   +1 more source

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Frontiers in Immunology, 2022
B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and are key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) and other viral infections, thereby ...
Monica D. Reece, Colin Song, Sarah C. Hancock, Susan Pereira Ribeiro, Deanna A. Kulpa, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano   +9 more
doaj   +1 more source

Mathematical modelling of internal HIV dynamics [PDF]

, 2009
We study a mathematical model for the viral dynamics of HIV in an infected individual in the presence of HAART. The paper starts with a literature review and then formulates the basic mathematical model.
University of Strathclyde (Funder), Dalal, Nirav, Greenhalgh, David, Mao, Xuerong   +3 more
core   +4 more sources

Impact of Analytical Treatment Interruption on Burden and Diversification of HIV Peripheral Reservoir: A Pilot Study

Viruses, 2021
Background: If analytical antiretroviral-treatment (ART) interruption (ATI) might significantly impact quantitative or qualitative peripheral-total HIV-DNA is still debated.
Rossana Scutari, Valentino Costabile, Laura Galli, Maria Concetta Bellocchi, Luca Carioti, Silvia Barbaliscia, Andrea Poli, Andrea Galli, Carlo Federico Perno, Maria Mercedes Santoro, Antonella Castagna, Francesca Ceccherini-Silberstein, Claudia Alteri, Vincenzo Spagnuolo   +13 more
doaj   +1 more source

Insights into the HIV-1 Latent Reservoir and Strategies to Cure HIV-1 Infection

Disease Markers, 2022
Since the first discovery of human immunodeficiency virus 1 (HIV-1) in 1983, the targeted treatment, antiretroviral therapy (ART), has effectively limited the detected plasma viremia below a very low level and the technique has been improved rapidly.
Ruojing Bai, Shiyun Lv, Hao Wu, Lili Dai
openaire   +2 more sources

Animal models for studies of HIV-1 brain reservoirs

Journal of Leukocyte Biology, 2022
AbstractThe HIV-1 often evades a robust antiretroviral-mediated immune response, leading to persistent infection within anatomically privileged sites including the CNS. Continuous low-level infection occurs in the presence of effective antiretroviral therapy (ART) in CD4+ T cells and mononuclear phagocytes (MP; monocytes, macrophages, microglia, and ...
Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D Kevadiya, K C Kent Lloyd, Howard E Gendelman, Santhi Gorantla, Larisa Y Poluektova, Prasanta K Dash   +8 more
openaire   +2 more sources

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

mBio, 2022
Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute
Julia Rubione, Paula S. Pérez, Alejandro Czernikier, Gabriel A. Duette, Federico Pehuen Pereyra Gerber, Jimena Salido, Martina P. Fabiano, Yanina Ghiglione, Gabriela Turk, Natalia Laufer, Alejandro J. Cagnoni, Juan M. Pérez Sáez, Joaquín P. Merlo, Carla Pascuale, Juan C. Stupirski, Omar Sued, Manuel Varas-Godoy, Sharon R. Lewin, Karina V. Mariño, Gabriel A. Rabinovich, Matías Ostrowski   +20 more
doaj   +1 more source

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

Nature Communications, 2018
The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al.
James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch   +14 more
doaj   +1 more source

HIV-1 Genomes Are Enriched in Memory CD4 ⁺ T-Cells with Short Half-Lives

mBio, 2021
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir.
Vincent Morcilla, Charline Bacchus-Souffan, Katie Fisher, Bethany A. Horsburgh, Bonnie Hiener, Xiao Qian Wang, Timothy E. Schlub, Mark Fitch, Rebecca Hoh, Frederick M. Hecht, Jeffrey N. Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Peter W. Hunt, Sarah Palmer   +15 more
doaj   +1 more source