Results 51 to 60 of about 34,792 (219)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Delivering CRISPR to the HIV-1 reservoirs

Frontiers in Microbiology
Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most complex and difficult viral infections to cure. The difficulty in developing curative strategies arises in large part from the development of latent viral reservoirs (LVRs) within anatomical and cellular compartments of a host.
Theodore E. Gurrola, Theodore E. Gurrola, Samuel N. Effah, Samuel N. Effah, Ilker K. Sariyer, Will Dampier, Will Dampier, Michael R. Nonnemacher, Michael R. Nonnemacher, Michael R. Nonnemacher, Brian Wigdahl, Brian Wigdahl, Brian Wigdahl   +12 more
openaire   +3 more sources

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes.

PLoS Pathogens
Human Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure.
Ghazal Sadri, Steven T Nadakal, William Lauer, Justin Kos, Parmit K Singh, Erin Elliott, Catherine W Kaiser, Easton E Ford, Nadia Richardson, Kaitlyn M Shields, Elizabeth Hudson, Noemi L Linden, Ali Danesh, James Powell, Peter Warburton, Juan Soto, Matthew Emery, Gintaras Deikus, Guinevere Q Lee, Susanna L Lamers, Steven J Reynolds, Ronald Galiwango, Jessica L Prodger, Stephen Tomusange, Taddeo Kityamuweesi, Tina Han, R Brad Jones, Aaron A R Tobian, Alan N Engelman, Robert Sebra, Susan Morgello, Andrew D Redd, David Sachs, Eric Rouchka, Melissa L Smith   +34 more
doaj   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence [PDF]

Current HIV Research, 2008
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escape the viral immune response and persist for long periods of time, despite the presence of successful highly active antiretroviral therapy (HAART). Given the
Aikaterini, Alexaki, Yujie, Liu, Brian, Wigdahl   +2 more
openaire   +2 more sources

Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross‐Sectional Study Using Cardiac MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Antiretroviral therapy has transformed HIV into a chronic condition, yet cardiac injury remains a major issue. Purpose To assess the ability of cardiac MR imaging markers to predict cardiac injury and disease progression in HIV‐infected individuals. Study Type Prospective.
Chunyan Deng, Wei Sun, Tianhu Gao, Haixia Chen, Lu Liu, Ran Li   +5 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

The impact of COVID‐19 on public perceptions of wild meat in Central Africa

People and Nature, EarlyView.
Abstract Wild meat is a significant source of food and income generation in Central Africa. However, there is little knowledge of how the assumed link between COVID‐19 and wild meat consumption has been discussed by the media and received by the public. In this study, we conducted media content analysis of 264 articles published in 2019–2020 related to
Yuhan Li, Lude Kinzonzi, Paul Loundou, Divin Malekani, Krossy Mavakala, Christian Mikolo Yobo, Katharine Abernethy, Matilda Eve Dunn, Donald Midoko Iponga, Robert Mwinyihali, Joss Wright, Eleanor Jane Milner‐Gulland, Lauren Coad, Juliet H. Wright, Daniel W. S. Challender   +14 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Advancements in single-cell techniques for examining the HIV reservoir: pathways to a cure

mBio
Human immunodeficiency virus (HIV) is largely incurable, due to the presence of a viral reservoir, which primarily consists of resting CD4+ T cells and other long-lived cells like macrophages.
Nokuzola Mbhele, Benjamin Chimukangara, Lynn Tyers, Frank Maldarelli, Andrew D. Redd   +4 more
doaj   +1 more source